RAD23B (RAD23 homolog B, nucleotide excision repair protein)

2003-02-01  

Identity

HGNC
LOCATION
9q31.2
LOCUSID
ALIAS
HHR23B,HR23B,P58
FUSION GENES

Other Information

Locus ID:

NCBI: 5887
MIM: 600062
HGNC: 9813
Ensembl: ENSG00000119318

Variants:

dbSNP: 5887
ClinVar: 5887
TCGA: ENSG00000119318
COSMIC: RAD23B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119318ENST00000358015P54727
ENSG00000119318ENST00000416373P54727
ENSG00000119318ENST00000419616Q5W0S5
ENSG00000119318ENST00000442587Q5W0S4
ENSG00000119318ENST00000457811H0Y579

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Nucleotide excision repairKEGGko03420
Nucleotide excision repairKEGGhsa03420
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
DeubiquitinationREACTOMER-HSA-5688426
Josephin domain DUBsREACTOMER-HSA-5689877

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128150742003A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.85
191829042009Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins.75
191163882009A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.63
229156582012Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group.58
197407552009Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex.51
165377132006Genetic variation in the nucleotide excision repair pathway and bladder cancer risk.46
201503662010DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.46
163997712006Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study.43
158497292005Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China.40
194449042009Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes.35

Citation

Dessen P

RAD23B (RAD23 homolog B, nucleotide excision repair protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42028/rad23b