| Nomenclature |
|---|
| HGNC (Hugo) | RAD50 9816 |
| Cards |
|---|
| Entrez_Gene (NCBI) | RAD50 10111 RAD50 homolog (S. cerevisiae) |
| GeneCards (Weizmann) | RAD50 |
| Ensembl hg19 (Hinxton) | ENSG00000113522 [Gene_View] chr5:131892616-131980313 [Contig_View] RAD50 [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000113522 [Gene_View] chr5:131892616-131980313 [Contig_View] RAD50 [Vega] |
| ICGC DataPortal | ENSG00000113522 |
| cBioPortal | RAD50 |
| AceView (NCBI) | RAD50 |
| Genatlas (Paris) | RAD50 |
| WikiGenes | 10111 |
| SOURCE (Princeton) | RAD50 |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | RAD50 - chr5:131892616-131980313 + 5q31.1 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | RAD50 - 5q31.1 [Description] (hg38-Dec_2013) |
| Ensembl | RAD50 - 5q31.1 [CytoView hg19] RAD50 - 5q31.1 [CytoView hg38] |
| Mapping of homologs : NCBI | RAD50 [Mapview hg19] RAD50 [Mapview hg38] |
| OMIM | 604040 613078 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF057299 AF057300 AK290597 AK307439 BC062603 |
| RefSeq transcript (Entrez) | NM_005732 NM_133482 |
| RefSeq genomic (Entrez) | AC_000137 NC_000005 NC_018916 NG_021151 NT_034772 NW_001838952 NW_004929323 |
| Consensus coding sequences : CCDS (NCBI) | RAD50 |
| Cluster EST : Unigene | Hs.633509 [ NCBI ] |
| CGAP (NCI) | Hs.633509 |
| Alternative Splicing : Fast-db (Paris) | GSHG0024228 |
| Alternative Splicing Gallery | ENSG00000113522 |
| Gene Expression | RAD50 [ NCBI-GEO ] RAD50 [ SEEK ] RAD50 [ MEM ] |
| SOURCE (Princeton) | Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q92878 (Uniprot) |
| NextProt | Q92878 [Medical] |
| With graphics : InterPro | Q92878 |
| Splice isoforms : SwissVar | Q92878 (Swissvar) |
| Domaine pattern : Prosite (Expaxy) | ZN_HOOK (PS51131) |
| Domains : Interpro (EBI) | P-loop_NTPase Rad50_eukaryotes Rad50_Zn_hook Zn_hook_Rad50 |
| Related proteins : CluSTr | Q92878 |
| Domain families : Pfam (Sanger) | Rad50_zn_hook (PF04423) |
| Domain families : Pfam (NCBI) | pfam04423 |
| DMDM Disease mutations | 10111 |
| Blocks (Seattle) | Q92878 |
| Human Protein Atlas | ENSG00000113522 |
| Peptide Atlas | Q92878 |
| HPRD | 04950 |
| IPI | IPI00305282 IPI00549205 IPI00107531 IPI01013687 IPI00658205 IPI00798033 IPI00852595 IPI00878541 IPI00894448 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q92878 |
| IntAct (EBI) | Q92878 |
| FunCoup | ENSG00000113522 |
| BioGRID | RAD50 |
| IntegromeDB | RAD50 |
| STRING (EMBL) | RAD50 |
| Ontologies - Pathways |
|---|
| QuickGO | Q92878 |
| Ontology : AmiGO | single-stranded DNA endodeoxyribonuclease activity regulation of mitotic recombination telomere maintenance double-strand break repair via homologous recombination DNA catabolic process, endonucleolytic nuclear chromosome, telomeric region DNA binding ATP-dependent DNA helicase activity protein binding ATP binding nucleus nucleoplasm nucleolus DNA repair DNA repair double-strand break repair double-strand break repair DNA recombination cellular response to DNA damage stimulus telomere maintenance via telomerase reciprocal meiotic recombination zinc ion binding 3'-5' exonuclease activity membrane protein binding, bridging Mre11 complex positive regulation of protein autophosphorylation DNA duplex unwinding positive regulation of kinase activity site of double-strand break pronucleus nucleic acid phosphodiester bond hydrolysis |
| Ontology : EGO-EBI | single-stranded DNA endodeoxyribonuclease activity regulation of mitotic recombination telomere maintenance double-strand break repair via homologous recombination DNA catabolic process, endonucleolytic nuclear chromosome, telomeric region DNA binding ATP-dependent DNA helicase activity protein binding ATP binding nucleus nucleoplasm nucleolus DNA repair DNA repair double-strand break repair double-strand break repair DNA recombination cellular response to DNA damage stimulus telomere maintenance via telomerase reciprocal meiotic recombination zinc ion binding 3'-5' exonuclease activity membrane protein binding, bridging Mre11 complex positive regulation of protein autophosphorylation DNA duplex unwinding positive regulation of kinase activity site of double-strand break pronucleus nucleic acid phosphodiester bond hydrolysis |
| Pathways : BIOCARTA | ATM Signaling Pathway [Genes] Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes] |
| Pathways : KEGG | Homologous recombination Non-homologous end-joining |
| Protein Interaction Database | RAD50 |
| DoCM (Curated mutations) | RAD50 |
| Wikipedia pathways | RAD50 |
| Gene fusion - rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | RAD50 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | RAD50 |
| dbVar | RAD50 |
| ClinVar | RAD50 |
| 1000_Genomes | RAD50 |
| Exome Variant Server | RAD50 |
| SNP (GeneSNP Utah) | RAD50 |
| SNP : HGBase | RAD50 |
| Genetic variants : HAPMAP | RAD50 |
| Genomic Variants (DGV) | RAD50 [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | ENSG00000113522 |
| Somatic Mutations in Cancer : COSMIC | RAD50 |
| CONAN: Copy Number Analysis | RAD50 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM) |
| LOVD (Leiden Open Variation Database) | **PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 5:131892616-131980313 |
| Mutations and Diseases : HGMD | RAD50 |
| OMIM | 604040 613078 |
| Medgen | RAD50 |
| NextProt | Q92878 [Medical] |
| GENETests | RAD50 |
| Disease Genetic Association | RAD50 |
| Huge Navigator |
RAD50 [HugePedia] RAD50 [HugeCancerGEM] |
| snp3D : Map Gene to Disease | 10111 |
| DGIdb (Drug Gene Interaction db) | RAD50 |
| General knowledge |
|---|
| Homologs : HomoloGene | RAD50 |
| Homology/Alignments : Family Browser (UCSC) | RAD50 |
| Phylogenetic Trees/Animal Genes : TreeFam | RAD50 |
| Chemical/Protein Interactions : CTD | 10111 |
| Chemical/Pharm GKB Gene | PA34175 |
| Clinical trial | RAD50 |
| Cancer Resource (Charite) | ENSG00000113522 |
| Other databases |
|---|
| Probes |
|---|
| Litterature |
|---|
| PubMed | 186 Pubmed reference(s) in Entrez |
| CoreMine | RAD50 |
| GoPubMed | RAD50 |
| iHOP | RAD50 |
