| Nomenclature | | HGNC (Hugo) | RAD50 9816 |
| Cards | | Entrez_Gene (NCBI) | RAD50 10111 RAD50 homolog (S. cerevisiae) |
| GeneCards (Weizmann) | RAD50 |
| Ensembl (Hinxton) | ENSG00000113522 [Gene_View] chr5:131892616-131980313 [Contig_View] RAD50 [Vega] |
| ICGC DataPortal | ENSG00000113522 |
| cBioPortal | RAD50 |
| AceView (NCBI) | RAD50 |
| Genatlas (Paris) | RAD50 |
| WikiGenes | 10111 |
| SOURCE (Princeton) | NM_005732 NM_133482 |
| Genomic and cartography | | GoldenPath (UCSC) | RAD50 - 5q31.1 chr5:131892616-131980313 + 5q31.1 [Description] (hg19-Feb_2009) |
| Ensembl | RAD50 - 5q31.1 [CytoView] |
| Mapping of homologs : NCBI | RAD50 [Mapview] |
| OMIM | 604040 613078 |
| Gene and transcription |
| Genbank (Entrez) | AF057299 AF057300 AK290597 AK307439 BC062603 |
| RefSeq transcript (Entrez) | NM_005732 NM_133482 |
| RefSeq genomic (Entrez) | AC_000137 NC_000005 NC_018916 NG_021151 NT_034772 NW_001838952 NW_004929323 |
| Consensus coding sequences : CCDS (NCBI) | RAD50 |
| Cluster EST : Unigene | Hs.633509 [ NCBI ] |
| CGAP (NCI) | Hs.633509 |
| Alternative Splicing : Fast-db (Paris) | GSHG0024228 |
| Alternative Splicing Gallery | ENSG00000113522 |
| Gene Expression | RAD50 [ NCBI-GEO ] RAD50 [ SEEK ] RAD50 [ MEM ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q92878 (Uniprot) |
| NextProt | Q92878 [Medical] |
| With graphics : InterPro | Q92878 |
| Splice isoforms : SwissVar | Q92878 (Swissvar) |
| Domaine pattern : Prosite (Expaxy) | ZN_HOOK (PS51131) |
| Domains : Interpro (EBI) | P-loop_NTPase [organisation] Rad50_eukaryotes [organisation] Rad50_Zn_hook [organisation] Zn_hook_Rad50 [organisation] |
| Related proteins : CluSTr | Q92878 |
| Domain families : Pfam (Sanger) | Rad50_zn_hook (PF04423) |
| Domain families : Pfam (NCBI) | pfam04423 |
| DMDM Disease mutations | 10111 |
| Blocks (Seattle) | Q92878 |
| Human Protein Atlas | ENSG00000113522 [gene] [tissue] [antibody] [cell] [cancer] |
| Peptide Atlas | Q92878 |
| HPRD | 04950 |
| IPI | IPI00305282 IPI00549205 IPI00107531 IPI01013687 IPI00658205 IPI00798033 IPI00852595 IPI00878541 IPI00894448 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q92878 |
| IntAct (EBI) | Q92878 |
| FunCoup | ENSG00000113522 |
| BioGRID | RAD50 |
| InParanoid | Q92878 |
| Interologous Interaction database | Q92878 |
| IntegromeDB | RAD50 |
| STRING (EMBL) | RAD50 |
| Ontologies - Pathways | | Ontology : AmiGO | single-stranded DNA endodeoxyribonuclease activity regulation of mitotic recombination telomere maintenance double-strand break repair via homologous recombination DNA catabolic process, endonucleolytic nuclear chromosome, telomeric region DNA binding ATP-dependent DNA helicase activity protein binding ATP binding nucleus nucleoplasm nucleolus DNA repair DNA repair double-strand break repair double-strand break repair DNA recombination cellular response to DNA damage stimulus telomere maintenance via telomerase reciprocal meiotic recombination zinc ion binding 3'-5' exonuclease activity membrane protein binding, bridging Mre11 complex positive regulation of protein autophosphorylation DNA duplex unwinding positive regulation of kinase activity site of double-strand break pronucleus nucleic acid phosphodiester bond hydrolysis |
| Ontology : EGO-EBI | single-stranded DNA endodeoxyribonuclease activity regulation of mitotic recombination telomere maintenance double-strand break repair via homologous recombination DNA catabolic process, endonucleolytic nuclear chromosome, telomeric region DNA binding ATP-dependent DNA helicase activity protein binding ATP binding nucleus nucleoplasm nucleolus DNA repair DNA repair double-strand break repair double-strand break repair DNA recombination cellular response to DNA damage stimulus telomere maintenance via telomerase reciprocal meiotic recombination zinc ion binding 3'-5' exonuclease activity membrane protein binding, bridging Mre11 complex positive regulation of protein autophosphorylation DNA duplex unwinding positive regulation of kinase activity site of double-strand break pronucleus nucleic acid phosphodiester bond hydrolysis |
| Pathways : BIOCARTA | ATM Signaling Pathway [Genes] Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes] |
| Pathways : KEGG | Homologous recombination Non-homologous end-joining |
| Protein Interaction Database | RAD50 |
| Wikipedia pathways | RAD50 |
| Gene fusion - rearrangments | | Polymorphisms : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | RAD50 |
| snp3D : Map Gene to Disease | 10111 |
| SNP (GeneSNP Utah) | RAD50 |
| SNP : HGBase | RAD50 |
| Genetic variants : HAPMAP | RAD50 |
| Exome Variant | RAD50 |
| 1000_Genomes | RAD50 |
| ICGC program | ENSG00000113522 |
| Somatic Mutations in Cancer : COSMIC | RAD50 |
| CONAN: Copy Number Analysis | RAD50 |
| Mutations and Diseases : HGMD | RAD50 |
| Genomic Variants | RAD50 RAD50 [DGVbeta] |
| dbVar | RAD50 |
| ClinVar | RAD50 |
| Pred. of missenses | PolyPhen-2 SIFT(SG) SIFT(JCVI) Align-GVGD MutAssessor Mutanalyser |
| Pred. splices | GeneSplicer Human Splicing Finder MaxEntScan |
| Diseases | | OMIM | 604040 613078 |
| Medgen | RAD50 |
| GENETests | RAD50 |
| Disease Genetic Association | RAD50 |
| Huge Navigator |
RAD50 [HugePedia] RAD50 [HugeCancerGEM] |
| General knowledge |
|---|
| Homologs : HomoloGene | RAD50 |
| Homology/Alignments : Family Browser (UCSC) | RAD50 |
| Phylogenetic Trees/Animal Genes : TreeFam | RAD50 |
| Chemical/Protein Interactions : CTD | 10111 |
| Chemical/Pharm GKB Gene | PA34175 |
| Clinical trial | RAD50 |
| Cancer Resource (Charite) | ENSG00000113522 |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 186 Pubmed reference(s) in Entrez |
| CoreMine | RAD50 |
| iHOP | RAD50 |
| OncoSearch | RAD50 |
