RAD51 (RAD51 recombinase)

2003-02-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
BRCC5,FANCR,HRAD51,HsRad51,HsT16930,MRMV2,RAD51A,RECA
FUSION GENES

Other Information

Locus ID:

NCBI: 5888
MIM: 179617
HGNC: 9817
Ensembl: ENSG00000051180

Variants:

dbSNP: 5888
ClinVar: 5888
TCGA: ENSG00000051180
COSMIC: RAD51

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000051180ENST00000267868Q06609
ENSG00000051180ENST00000382643Q06609
ENSG00000051180ENST00000423169Q06609
ENSG00000051180ENST00000525066E9PJ30
ENSG00000051180ENST00000526763Q9NZG9
ENSG00000051180ENST00000527860E9PNT5
ENSG00000051180ENST00000531277E9PI54
ENSG00000051180ENST00000532743Q06609
ENSG00000051180ENST00000533741H0YD61
ENSG00000051180ENST00000557850Q06609
ENSG00000051180ENST00000645673Q06609

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Pancreatic cancerKEGGko05212
Homologous recombinationKEGGhsa03440
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
201886682010Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.347
227895422012A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.338
207298322010Purified human BRCA2 stimulates RAD51-mediated recombination.258
204009642010Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.242
124421712002Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.218
122391512002S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.195
257337142015Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.183
207298592010Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.161
152265062004Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity.121
122422782002Homologous recombination resolution defect in werner syndrome.107

Citation

Dessen P

RAD51 (RAD51 recombinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/150/rad51