Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAD51 (RAD51 recombinase)

Identity

Other namesBRCC5
FANCR
HRAD51
HsRad51
HsT16930
MRMV2
RAD51A
RECA
HGNC (Hugo) RAD51
LocusID (NCBI) 5888
Atlas_Id 150
Location 15q15.1
Location_base_pair Starts at 40987378 and ends at 41024356 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAD51 (15q15.1) / CDCA5 (11q13.1)RMDN3 (15q15.1) / RAD51 (15q15.1)SLC2A9 (4p16.1) / RAD51 (15q15.1)
SLC2A9 4p16.1 / RAD51 15q15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Chronic myelogenous leukaemia (CML)
t(1;9)(p34;q34) SFPQ/ABL1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Fallopian tube tumors: an overview
Kidney: Clear cell sarcoma with t(10;17)(q22;p13) YWHAE/NUTM2E

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary breast cancer

External links

Nomenclature
HGNC (Hugo)RAD51   9817
Cards
Entrez_Gene (NCBI)RAD51  5888  RAD51 recombinase
GeneCards (Weizmann)RAD51
Ensembl hg19 (Hinxton)ENSG00000051180 [Gene_View]  chr15:40987378-41024356 [Contig_View]  RAD51 [Vega]
Ensembl hg38 (Hinxton)ENSG00000051180 [Gene_View]  chr15:40987378-41024356 [Contig_View]  RAD51 [Vega]
ICGC DataPortalENSG00000051180
TCGA cBioPortalRAD51
AceView (NCBI)RAD51
Genatlas (Paris)RAD51
WikiGenes5888
SOURCE (Princeton)RAD51
Genomic and cartography
GoldenPath hg19 (UCSC)RAD51  -     chr15:40987378-41024356 +  15q15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAD51  -     15q15.1   [Description]    (hg38-Dec_2013)
EnsemblRAD51 - 15q15.1 [CytoView hg19]  RAD51 - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBIRAD51 [Mapview hg19]  RAD51 [Mapview hg38]
OMIM114480   179617   614508   
Gene and transcription
Genbank (Entrez)AK131299 AK291969 AK303089 AK313503 AU100170
RefSeq transcript (Entrez)NM_001164269 NM_001164270 NM_002875 NM_133487
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_012120 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)RAD51
Cluster EST : UnigeneHs.631709 [ NCBI ]
CGAP (NCI)Hs.631709
Alternative Splicing : Fast-db (Paris)GSHG0009784
Alternative Splicing GalleryENSG00000051180
Gene ExpressionRAD51 [ NCBI-GEO ]   RAD51 [ EBI - ARRAY_EXPRESS ]   RAD51 [ SEEK ]   RAD51 [ MEM ]
Gene Expression Viewer (FireBrowse)RAD51 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)5888
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ06609 (Uniprot)
NextProtQ06609  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ06609
Splice isoforms : SwissVarQ06609 (Swissvar)
PhosPhoSitePlusQ06609
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)    RECA_3 (PS50163)   
Domains : Interpro (EBI)AAA+_ATPase    DNA_recomb/repair_Rad51    DNA_recomb/repair_Rad51_C    DNA_recomb/repair_RecA-like    DNA_repair_Rad51/TF_NusA_a-hlx    Hlx-hairpin-Hlx_DNA-bd_motif    P-loop_NTPase    RecA_ATP-bd    RecA_monomer-monomer_interface   
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Domain families : Smart (EMBL)AAA (SM00382)  HhH1 (SM00278)  
DMDM Disease mutations5888
Blocks (Seattle)RAD51
PDB (SRS)1B22    1N0W   
PDB (PDBSum)1B22    1N0W   
PDB (IMB)1B22    1N0W   
PDB (RSDB)1B22    1N0W   
Structural Biology KnowledgeBase1B22    1N0W   
SCOP (Structural Classification of Proteins)1B22    1N0W   
CATH (Classification of proteins structures)1B22    1N0W   
SuperfamilyQ06609
Human Protein AtlasENSG00000051180
Peptide AtlasQ06609
HPRD01557
IPIIPI00032201   IPI00220649   IPI01010370   IPI00910146   IPI01018851   IPI00980924   IPI00553199   IPI00976981   IPI00982914   IPI00985266   
Protein Interaction databases
DIP (DOE-UCLA)Q06609
IntAct (EBI)Q06609
FunCoupENSG00000051180
BioGRIDRAD51
STRING (EMBL)RAD51
ZODIACRAD51
Ontologies - Pathways
QuickGOQ06609
Ontology : AmiGOrecombinase activity  nuclear chromosome  four-way junction DNA binding  telomere maintenance via recombination  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA recombinase assembly  DNA synthesis involved in DNA repair  strand displacement  nuclear chromosome, telomeric region  chromatin  condensed chromosome  condensed nuclear chromosome  condensed nuclear chromosome  lateral element  regulation of protein phosphorylation  chromatin binding  double-stranded DNA binding  single-stranded DNA binding  endodeoxyribonuclease activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  microtubule organizing center  DNA unwinding involved in DNA replication  DNA repair  DNA recombination  mitotic recombination  cellular response to DNA damage stimulus  meiotic nuclear division  reciprocal meiotic recombination  protein C-terminus binding  response to toxic substance  response to X-ray  regulation of double-strand break repair via homologous recombination  telomere maintenance via telomere lengthening  PML body  replication fork processing  replication fork processing  site of double-strand break  strand invasion  response to drug  identical protein binding  single-stranded DNA-dependent ATPase activity  perinuclear region of cytoplasm  positive regulation of DNA ligation  protein homooligomerization  DNA polymerase binding  chromosome organization involved in meiotic cell cycle  cellular response to ionizing radiation  cellular response to gamma radiation  cellular response to hydroxyurea  cellular response to cisplatin  cellular response to camptothecin  response to etoposide  replication-born double-strand break repair via sister chromatid exchange  homologous recombination-dependent replication fork processing  
Ontology : EGO-EBIrecombinase activity  nuclear chromosome  four-way junction DNA binding  telomere maintenance via recombination  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA recombinase assembly  DNA synthesis involved in DNA repair  strand displacement  nuclear chromosome, telomeric region  chromatin  condensed chromosome  condensed nuclear chromosome  condensed nuclear chromosome  lateral element  regulation of protein phosphorylation  chromatin binding  double-stranded DNA binding  single-stranded DNA binding  endodeoxyribonuclease activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  microtubule organizing center  DNA unwinding involved in DNA replication  DNA repair  DNA recombination  mitotic recombination  cellular response to DNA damage stimulus  meiotic nuclear division  reciprocal meiotic recombination  protein C-terminus binding  response to toxic substance  response to X-ray  regulation of double-strand break repair via homologous recombination  telomere maintenance via telomere lengthening  PML body  replication fork processing  replication fork processing  site of double-strand break  strand invasion  response to drug  identical protein binding  single-stranded DNA-dependent ATPase activity  perinuclear region of cytoplasm  positive regulation of DNA ligation  protein homooligomerization  DNA polymerase binding  chromosome organization involved in meiotic cell cycle  cellular response to ionizing radiation  cellular response to gamma radiation  cellular response to hydroxyurea  cellular response to cisplatin  cellular response to camptothecin  response to etoposide  replication-born double-strand break repair via sister chromatid exchange  homologous recombination-dependent replication fork processing  
Pathways : BIOCARTAATM Signaling Pathway [Genes]    Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]   
Pathways : KEGGHomologous recombination    Fanconi anemia pathway    Pathways in cancer    Pancreatic cancer   
NDEx Network
Atlas of Cancer Signalling NetworkRAD51
Wikipedia pathwaysRAD51
Orthology - Evolution
OrthoDB5888
GeneTree (enSembl)ENSG00000051180
Phylogenetic Trees/Animal Genes : TreeFamRAD51
Homologs : HomoloGeneRAD51
Homology/Alignments : Family Browser (UCSC)RAD51
Gene fusions - Rearrangements
Fusion: TCGASLC2A9 4p16.1 RAD51 15q15.1 BLCA
Polymorphisms : SNP, variants
NCBI Variation ViewerRAD51 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD51
dbVarRAD51
ClinVarRAD51
1000_GenomesRAD51 
Exome Variant ServerRAD51
ExAC (Exome Aggregation Consortium)RAD51 (select the gene name)
SNP (GeneSNP Utah)RAD51
SNP : HGBaseRAD51
Genetic variants : HAPMAPRAD51
Genomic Variants (DGV)RAD51 [DGVbeta]
Mutations
ICGC Data PortalRAD51 
TCGA Data PortalRAD51 
Broad Tumor PortalRAD51
OASIS PortalRAD51 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAD51 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAD51
DgiDB (Drug Gene Interaction Database)RAD51
DoCM (Curated mutations)RAD51 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD51 (select a term)
intoGenRAD51
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:40987378-41024356
CONAN: Copy Number AnalysisRAD51 
Mutations and Diseases : HGMDRAD51
OMIM114480    179617    614508   
MedgenRAD51
Genetic Testing Registry RAD51
NextProtQ06609 [Medical]
TSGene5888
GENETestsRAD51
Huge Navigator RAD51 [HugePedia]  RAD51 [HugeCancerGEM]
snp3D : Map Gene to Disease5888
BioCentury BCIQRAD51
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5888
Chemical/Pharm GKB GenePA34176
Clinical trialRAD51
Miscellaneous
canSAR (ICR)RAD51 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAD51
GoPubMedRAD51
iHOPRAD51
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 18:01:26 CEST 2016

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