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RAD51 (RAD51 recombinase)

Identity

Other namesBRCC5
HRAD51
HsRad51
HsT16930
MRMV2
RAD51A
RECA
HGNC (Hugo) RAD51
LocusID (NCBI) 5888
Location 15q15.1
Location_base_pair Starts at 40987378 and ends at 41024356 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)RAD51   9817
Cards
Entrez_Gene (NCBI)RAD51  5888  RAD51 recombinase
GeneCards (Weizmann)RAD51
Ensembl (Hinxton)ENSG00000051180 [Gene_View]  chr15:40987378-41024356 [Contig_View]  RAD51 [Vega]
ICGC DataPortalENSG00000051180
cBioPortalRAD51
AceView (NCBI)RAD51
Genatlas (Paris)RAD51
WikiGenes5888
SOURCE (Princeton)NM_001164269 NM_001164270 NM_002875 NM_133487
Genomic and cartography
GoldenPath (UCSC)RAD51  -  15q15.1   chr15:40987378-41024356 +  15q15.1   [Description]    (hg19-Feb_2009)
EnsemblRAD51 - 15q15.1 [CytoView]
Mapping of homologs : NCBIRAD51 [Mapview]
OMIM114480   179617   614508   
Gene and transcription
Genbank (Entrez)AK131299 AK291969 AK303089 AK313503 AU100170
RefSeq transcript (Entrez)NM_001164269 NM_001164270 NM_002875 NM_133487
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_012120 NT_010194 NW_001838214 NW_004929398
Consensus coding sequences : CCDS (NCBI)RAD51
Cluster EST : UnigeneHs.631709 [ NCBI ]
CGAP (NCI)Hs.631709
Alternative Splicing : Fast-db (Paris)GSHG0009784
Alternative Splicing GalleryENSG00000051180
Gene ExpressionRAD51 [ NCBI-GEO ]     RAD51 [ SEEK ]   RAD51 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ06609 (Uniprot)
NextProtQ06609  [Medical]
With graphics : InterProQ06609
Splice isoforms : SwissVarQ06609 (Swissvar)
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)    RECA_3 (PS50163)   
Domains : Interpro (EBI)AAA+_ATPase [organisation]   DNA_recomb/repair_Rad51 [organisation]   DNA_recomb/repair_Rad51_C [organisation]   DNA_recomb/repair_RecA-like [organisation]   DNA_repair_Rad51/TF_NusA_a-hlx [organisation]   Hlx-hairpin-Hlx_DNA-bd_motif [organisation]   P-loop_NTPase [organisation]   RecA_ATP-bd [organisation]   RecA_monomer-monomer_interface [organisation]  
Related proteins : CluSTrQ06609
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Domain families : Smart (EMBL)AAA (SM00382)  HhH1 (SM00278)  
DMDM Disease mutations5888
Blocks (Seattle)Q06609
PDB (SRS)1B22    1N0W   
PDB (PDBSum)1B22    1N0W   
PDB (IMB)1B22    1N0W   
PDB (RSDB)1B22    1N0W   
Human Protein AtlasENSG00000051180 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ06609
HPRD01557
IPIIPI00032201   IPI00220649   IPI01010370   IPI00910146   IPI01018851   IPI00980924   IPI00553199   IPI00976981   IPI00982914   IPI00985266   
Protein Interaction databases
DIP (DOE-UCLA)Q06609
IntAct (EBI)Q06609
FunCoupENSG00000051180
BioGRIDRAD51
InParanoidQ06609
Interologous Interaction database Q06609
IntegromeDBRAD51
STRING (EMBL)RAD51
Ontologies - Pathways
Ontology : AmiGOnuclear chromosome  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA recombinase assembly  condensed chromosome  condensed nuclear chromosome  lateral element  damaged DNA binding  double-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  microtubule organizing center  ATP catabolic process  ATP catabolic process  DNA unwinding involved in DNA replication  DNA repair  double-strand break repair  DNA recombination  mitotic recombination  cellular response to DNA damage stimulus  meiotic nuclear division  reciprocal meiotic recombination  protein C-terminus binding  regulation of double-strand break repair via homologous recombination  PML body  identical protein binding  single-stranded DNA-dependent ATPase activity  perinuclear region of cytoplasm  positive regulation of DNA ligation  protein homooligomerization  DNA polymerase binding  cellular response to ionizing radiation  cellular response to camptothecin  
Ontology : EGO-EBInuclear chromosome  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA recombinase assembly  condensed chromosome  condensed nuclear chromosome  lateral element  damaged DNA binding  double-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  microtubule organizing center  ATP catabolic process  ATP catabolic process  DNA unwinding involved in DNA replication  DNA repair  double-strand break repair  DNA recombination  mitotic recombination  cellular response to DNA damage stimulus  meiotic nuclear division  reciprocal meiotic recombination  protein C-terminus binding  regulation of double-strand break repair via homologous recombination  PML body  identical protein binding  single-stranded DNA-dependent ATPase activity  perinuclear region of cytoplasm  positive regulation of DNA ligation  protein homooligomerization  DNA polymerase binding  cellular response to ionizing radiation  cellular response to camptothecin  
Pathways : BIOCARTAATM Signaling Pathway [Genes]    Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]   
Pathways : KEGGHomologous recombination    Fanconi anemia pathway    Pathways in cancer    Pancreatic cancer   
Protein Interaction DatabaseRAD51
Wikipedia pathwaysRAD51
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RAD51
snp3D : Map Gene to Disease5888
SNP (GeneSNP Utah)RAD51
SNP : HGBaseRAD51
Genetic variants : HAPMAPRAD51
Exome VariantRAD51
1000_GenomesRAD51 
ICGC programENSG00000051180 
Somatic Mutations in Cancer : COSMICRAD51 
CONAN: Copy Number AnalysisRAD51 
Mutations and Diseases : HGMDRAD51
Mutations and Diseases : intOGenRAD51
Genomic VariantsRAD51  RAD51 [DGVbeta]
dbVarRAD51
ClinVarRAD51
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM114480    179617    614508   
MedgenRAD51
GENETestsRAD51
Disease Genetic AssociationRAD51
Huge Navigator RAD51 [HugePedia]  RAD51 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneRAD51
Homology/Alignments : Family Browser (UCSC)RAD51
Phylogenetic Trees/Animal Genes : TreeFamRAD51
Chemical/Protein Interactions : CTD5888
Chemical/Pharm GKB GenePA34176
Clinical trialRAD51
Cancer Resource (Charite)ENSG00000051180
Other databases
Probes
Litterature
PubMed433 Pubmed reference(s) in Entrez
CoreMineRAD51
iHOPRAD51
OncoSearchRAD51
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:02:16 CEST 2014

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