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RAD54L (RAD54 like (S. cerevisiae))

Identity

Alias_namesRAD54 (S.cerevisiae)-like
Alias_symbol (synonym)hHR54
hRAD54
RAD54A
Other aliasHR54
HGNC (Hugo) RAD54L
LocusID (NCBI) 8438
Atlas_Id 348
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 46247695 and ends at 46278473 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAAH (1p33) / RAD54L (1p34.1)RAD54L (1p34.1) / LRRC41 (1p34.1)RAD54L (1p34.1) / VASH2 (1q32.3)
RPAP1 (15q15.1) / RAD54L (1p34.1)FAAH 1p33 / RAD54L 1p34.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary breast cancer


External links

Nomenclature
HGNC (Hugo)RAD54L   9826
Cards
Entrez_Gene (NCBI)RAD54L  8438  RAD54 like (S. cerevisiae)
AliasesHR54; RAD54A; hHR54; hRAD54
GeneCards (Weizmann)RAD54L
Ensembl hg19 (Hinxton)ENSG00000085999 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085999 [Gene_View]  chr1:46247695-46278473 [Contig_View]  RAD54L [Vega]
ICGC DataPortalENSG00000085999
TCGA cBioPortalRAD54L
AceView (NCBI)RAD54L
Genatlas (Paris)RAD54L
WikiGenes8438
SOURCE (Princeton)RAD54L
Genetics Home Reference (NIH)RAD54L
Genomic and cartography
GoldenPath hg38 (UCSC)RAD54L  -     chr1:46247695-46278473 +  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAD54L  -     1p34.1   [Description]    (hg19-Feb_2009)
EnsemblRAD54L - 1p34.1 [CytoView hg19]  RAD54L - 1p34.1 [CytoView hg38]
Mapping of homologs : NCBIRAD54L [Mapview hg19]  RAD54L [Mapview hg38]
OMIM114480   603615   605027   
Gene and transcription
Genbank (Entrez)AA582917 AK292611 AK297204 BC121059 BC121060
RefSeq transcript (Entrez)NM_001142548 NM_003579
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAD54L
Cluster EST : UnigeneHs.642042 [ NCBI ]
CGAP (NCI)Hs.642042
Alternative Splicing GalleryENSG00000085999
Gene ExpressionRAD54L [ NCBI-GEO ]   RAD54L [ EBI - ARRAY_EXPRESS ]   RAD54L [ SEEK ]   RAD54L [ MEM ]
Gene Expression Viewer (FireBrowse)RAD54L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8438
GTEX Portal (Tissue expression)RAD54L
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92698   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92698  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92698
Splice isoforms : SwissVarQ92698
Catalytic activity : Enzyme3.6.4.- [ Enzyme-Expasy ]   3.6.4.-3.6.4.- [ IntEnz-EBI ]   3.6.4.- [ BRENDA ]   3.6.4.- [ KEGG ]   
PhosPhoSitePlusQ92698
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)Helicase_ATP-bd    Helicase_C    P-loop_NTPase    SNF2_N   
Domain families : Pfam (Sanger)Helicase_C (PF00271)    SNF2_N (PF00176)   
Domain families : Pfam (NCBI)pfam00271    pfam00176   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)RAD54L
DMDM Disease mutations8438
Blocks (Seattle)RAD54L
SuperfamilyQ92698
Human Protein AtlasENSG00000085999
Peptide AtlasQ92698
HPRD04683
IPIIPI00294292   IPI01012805   
Protein Interaction databases
DIP (DOE-UCLA)Q92698
IntAct (EBI)Q92698
FunCoupENSG00000085999
BioGRIDRAD54L
STRING (EMBL)RAD54L
ZODIACRAD54L
Ontologies - Pathways
QuickGOQ92698
Ontology : AmiGOdouble-strand break repair via homologous recombination  DNA strand renaturation  DNA binding  helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  DNA repair  DNA recombination  determination of adult lifespan  response to ionizing radiation  annealing helicase activity  response to drug  meiotic cell cycle  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  DNA strand renaturation  DNA binding  helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  DNA repair  DNA recombination  determination of adult lifespan  response to ionizing radiation  annealing helicase activity  response to drug  meiotic cell cycle  
Pathways : KEGGHomologous recombination   
NDEx NetworkRAD54L
Atlas of Cancer Signalling NetworkRAD54L
Wikipedia pathwaysRAD54L
Orthology - Evolution
OrthoDB8438
GeneTree (enSembl)ENSG00000085999
Phylogenetic Trees/Animal Genes : TreeFamRAD54L
HOVERGENQ92698
HOGENOMQ92698
Homologs : HomoloGeneRAD54L
Homology/Alignments : Family Browser (UCSC)RAD54L
Gene fusions - Rearrangements
Fusion : MitelmanFAAH/RAD54L [1p33/1p34.1]  [t(1;1)(p33;p34)]  
Fusion: TCGAFAAH 1p33 RAD54L 1p34.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD54L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD54L
dbVarRAD54L
ClinVarRAD54L
1000_GenomesRAD54L 
Exome Variant ServerRAD54L
ExAC (Exome Aggregation Consortium)RAD54L (select the gene name)
Genetic variants : HAPMAP8438
Genomic Variants (DGV)RAD54L [DGVbeta]
DECIPHERRAD54L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAD54L 
Mutations
ICGC Data PortalRAD54L 
TCGA Data PortalRAD54L 
Broad Tumor PortalRAD54L
OASIS PortalRAD54L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAD54L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAD54L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAD54L
DgiDB (Drug Gene Interaction Database)RAD54L
DoCM (Curated mutations)RAD54L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD54L (select a term)
intoGenRAD54L
Cancer3DRAD54L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114480    603615    605027   
Orphanet19054   
MedgenRAD54L
Genetic Testing Registry RAD54L
NextProtQ92698 [Medical]
TSGene8438
GENETestsRAD54L
Target ValidationRAD54L
Huge Navigator RAD54L [HugePedia]
snp3D : Map Gene to Disease8438
BioCentury BCIQRAD54L
ClinGenRAD54L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8438
Chemical/Pharm GKB GenePA34181
Clinical trialRAD54L
Miscellaneous
canSAR (ICR)RAD54L (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAD54L
EVEXRAD54L
GoPubMedRAD54L
iHOPRAD54L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:27:54 CEST 2017

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