RAET1L (retinoic acid early transcript 1L)

2015-08-01 Affiliation

Identity

HGNC

RAET1L

LOCATION

6q25.1

LOCUSID

154064

ALIAS

ULBP6

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 154064
MIM: 611047
HGNC: 16798
Ensembl: ENSG00000155918

Variants:

dbSNP: 154064
ClinVar: 154064
TCGA: ENSG00000155918
COSMIC: RAET1L

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000155918	ENST00000286380	Q5VY80
ENSG00000155918	ENST00000367341	Q5VY80

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteins	REACTOME	R-HSA-163125

References

Pubmed ID	Year	Title	Citations
19658097	2009	ULBP6/RAET1L is an additional human NKG2D ligand.	44
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
25212604	2014	Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.	16
19688209	2009	Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais.	8
23025544	2012	The genotype of RAET1L (ULBP6), a ligand for human NKG2D (KLRK1), markedly influences the clinical outcome of allogeneic stem cell transplantation.	8
20219610	2010	Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.	7
20219610	2010	Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.	7
28559451	2017	A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.	5

Citation

Dessen P

RAET1L (retinoic acid early transcript 1L)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55312/raet1l