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RAG2 (recombination activating gene 2)

Identity

Other namesRAG-2
HGNC (Hugo) RAG2
LocusID (NCBI) 5897
Atlas_Id 351
Location 11p12  [Link to chromosome band 11p12]
Location_base_pair Starts at 36613493 and ends at 36619829 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAG2 (11p12) / BACH2 (6q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 18 ]
  del(11)(p12p13) LMO2
dic(3;9)(p14;p13) PAX5/FOXP1
dic(7;9)(p11-12;p12-13) PAX5/LOC392027
dic(9;12)(p13;p12) PAX5/SLCO1B3
dic(9;16)(p13;q11) PAX5/?
dic(9;17)(p13;q11) PAX5/TAOK1
dic(9;18)(p13;q11) PAX5/ZNF521
t(1;9)(p13;p12) PAX5/HIPK1
inv(7)(p15q34) TRB/HOXA10;t(7;7)(p15;q34) TRB/HOXA10
t(7;9)(q11;p12) PAX5/POM121
t(8;9)(q24;p13) ?/MYC
t(9;9)(p13;p24) PAX5/JAK2;del(9)(p13p24) PAX5/JAK2;inv(9)(p13p24) PAX5/JAK2
t(9;13)(p12;q21) PAX5/DACH1
t(9;15)(p13;q24) PAX5/PML
t(9;15)(p13;q24) PAX5/GOLGA6A
t(9;17)(p13;p12) PAX5/NCOR1
t(9;22)(p13;q13) PAX5/BRD1
t(X;9)(q21;p13) PAX5/DACH2

External links

Nomenclature
HGNC (Hugo)RAG2   9832
Cards
Entrez_Gene (NCBI)RAG2  5897  recombination activating gene 2
AliasesRAG-2
GeneCards (Weizmann)RAG2
Ensembl hg19 (Hinxton)ENSG00000175097 [Gene_View]  chr11:36613493-36619829 [Contig_View]  RAG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000175097 [Gene_View]  chr11:36613493-36619829 [Contig_View]  RAG2 [Vega]
ICGC DataPortalENSG00000175097
TCGA cBioPortalRAG2
AceView (NCBI)RAG2
Genatlas (Paris)RAG2
WikiGenes5897
SOURCE (Princeton)RAG2
Genomic and cartography
GoldenPath hg19 (UCSC)RAG2  -     chr11:36613493-36619829 -  11p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAG2  -     11p12   [Description]    (hg38-Dec_2013)
EnsemblRAG2 - 11p12 [CytoView hg19]  RAG2 - 11p12 [CytoView hg38]
Mapping of homologs : NCBIRAG2 [Mapview hg19]  RAG2 [Mapview hg38]
OMIM179616   233650   601457   603554   
Gene and transcription
Genbank (Entrez)AF080577 AK292664 AW058148 BC022397 BM457214
RefSeq transcript (Entrez)NM_000536 NM_001243785 NM_001243786
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_007573 NG_033154 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)RAG2
Cluster EST : UnigeneHs.714519 [ NCBI ]
CGAP (NCI)Hs.714519
Alternative Splicing GalleryENSG00000175097
Gene ExpressionRAG2 [ NCBI-GEO ]   RAG2 [ EBI - ARRAY_EXPRESS ]   RAG2 [ SEEK ]   RAG2 [ MEM ]
Gene Expression Viewer (FireBrowse)RAG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5897
GTEX Portal (Tissue expression)RAG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55895 (Uniprot)
NextProtP55895  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55895
Splice isoforms : SwissVarP55895 (Swissvar)
PhosPhoSitePlusP55895
Domains : Interpro (EBI)Gal_Oxase/kelch_b-propeller    Kelch-typ_b-propeller    RAG2    RAG2_PHD    Znf_FYVE_PHD   
Domain families : Pfam (Sanger)RAG2 (PF03089)    RAG2_PHD (PF13341)   
Domain families : Pfam (NCBI)pfam03089    pfam13341   
DMDM Disease mutations5897
Blocks (Seattle)RAG2
SuperfamilyP55895
Human Protein AtlasENSG00000175097
Peptide AtlasP55895
HPRD08913
IPIIPI00299162   IPI00984863   IPI00976391   
Protein Interaction databases
DIP (DOE-UCLA)P55895
IntAct (EBI)P55895
FunCoupENSG00000175097
BioGRIDRAG2
STRING (EMBL)RAG2
ZODIACRAG2
Ontologies - Pathways
QuickGOP55895
Ontology : AmiGOB cell lineage commitment  pre-B cell allelic exclusion  B cell homeostatic proliferation  T cell lineage commitment  DNA binding  chromatin binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleoplasm  zinc ion binding  protein ubiquitination  chromatin modification  B cell differentiation  T cell differentiation in thymus  V(D)J recombination  methylated histone binding  phosphatidylinositol binding  phosphatidylinositol-3,4-bisphosphate binding  positive regulation of organ growth  ubiquitin protein ligase activity  phosphatidylinositol-3,5-bisphosphate binding  
Ontology : EGO-EBIB cell lineage commitment  pre-B cell allelic exclusion  B cell homeostatic proliferation  T cell lineage commitment  DNA binding  chromatin binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleoplasm  zinc ion binding  protein ubiquitination  chromatin modification  B cell differentiation  T cell differentiation in thymus  V(D)J recombination  methylated histone binding  phosphatidylinositol binding  phosphatidylinositol-3,4-bisphosphate binding  positive regulation of organ growth  ubiquitin protein ligase activity  phosphatidylinositol-3,5-bisphosphate binding  
Pathways : KEGGFoxO signaling pathway    Primary immunodeficiency   
NDEx NetworkRAG2
Atlas of Cancer Signalling NetworkRAG2
Wikipedia pathwaysRAG2
Orthology - Evolution
OrthoDB5897
GeneTree (enSembl)ENSG00000175097
Phylogenetic Trees/Animal Genes : TreeFamRAG2
Homologs : HomoloGeneRAG2
Homology/Alignments : Family Browser (UCSC)RAG2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRAG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAG2
dbVarRAG2
ClinVarRAG2
1000_GenomesRAG2 
Exome Variant ServerRAG2
ExAC (Exome Aggregation Consortium)RAG2 (select the gene name)
Genetic variants : HAPMAP5897
Genomic Variants (DGV)RAG2 [DGVbeta]
Mutations
ICGC Data PortalRAG2 
TCGA Data PortalRAG2 
Broad Tumor PortalRAG2
OASIS PortalRAG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAG2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch RAG2
DgiDB (Drug Gene Interaction Database)RAG2
DoCM (Curated mutations)RAG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAG2 (select a term)
intoGenRAG2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:36613493-36619829  ENSG00000175097
CONAN: Copy Number AnalysisRAG2 
Mutations and Diseases : HGMDRAG2
OMIM179616    233650    601457    603554   
MedgenRAG2
Genetic Testing Registry RAG2
NextProtP55895 [Medical]
TSGene5897
GENETestsRAG2
Huge Navigator RAG2 [HugePedia]
snp3D : Map Gene to Disease5897
BioCentury BCIQRAG2
ClinGenRAG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5897
Chemical/Pharm GKB GenePA34186
Clinical trialRAG2
Miscellaneous
canSAR (ICR)RAG2 (select the gene name)
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAG2
EVEXRAG2
GoPubMedRAG2
iHOPRAG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 19:09:57 CEST 2016

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