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RAG2 (recombination activating gene 2)

Identity

Other namesRAG-2
HGNC (Hugo) RAG2
LocusID (NCBI) 5897
Location 11p12
Location_base_pair Starts at 36613493 and ends at 36619829 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615 11q23ID1030 11q23secondLeukID1131 t1119ELLID1029 t0812q24q22ID2057
t0814ID1050 8p11inMPDID1091 inv8p11q13ID1189 PrimarCutanALCLID2118 t0708q34p11ID1409
t0809p12q33ID1129 t0811p11p15ID1200 t0811p12p15ID1521 t0812p12p11ID1330 t0812p12q15ID1201
t0817p12q23ID1387

External links

Nomenclature
HGNC (Hugo)RAG2   9832
Cards
Entrez_Gene (NCBI)RAG2  5897  recombination activating gene 2
GeneCards (Weizmann)RAG2
Ensembl hg19 (Hinxton)ENSG00000175097 [Gene_View]  chr11:36613493-36619829 [Contig_View]  RAG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000175097 [Gene_View]  chr11:36613493-36619829 [Contig_View]  RAG2 [Vega]
ICGC DataPortalENSG00000175097
cBioPortalRAG2
AceView (NCBI)RAG2
Genatlas (Paris)RAG2
WikiGenes5897
SOURCE (Princeton)RAG2
Genomic and cartography
GoldenPath hg19 (UCSC)RAG2  -     chr11:36613493-36619829 -  11p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAG2  -     11p12   [Description]    (hg38-Dec_2013)
EnsemblRAG2 - 11p12 [CytoView hg19]  RAG2 - 11p12 [CytoView hg38]
Mapping of homologs : NCBIRAG2 [Mapview hg19]  RAG2 [Mapview hg38]
OMIM179616   233650   601457   603554   
Gene and transcription
Genbank (Entrez)AF080577 AK292664 AW058148 BC022397 BM457214
RefSeq transcript (Entrez)NM_000536 NM_001243785 NM_001243786
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_007573 NG_033154 NT_009237 NW_001838022 NW_004929378
Consensus coding sequences : CCDS (NCBI)RAG2
Cluster EST : UnigeneHs.714519 [ NCBI ]
CGAP (NCI)Hs.714519
Alternative Splicing : Fast-db (Paris)GSHG0005702
Alternative Splicing GalleryENSG00000175097
Gene ExpressionRAG2 [ NCBI-GEO ]     RAG2 [ SEEK ]   RAG2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55895 (Uniprot)
NextProtP55895  [Medical]
With graphics : InterProP55895
Splice isoforms : SwissVarP55895 (Swissvar)
Domains : Interpro (EBI)Gal_Oxase/kelch_b-propeller    Kelch-typ_b-propeller    RAG2    RAG2_PHD    Znf_FYVE_PHD   
Related proteins : CluSTrP55895
Domain families : Pfam (Sanger)RAG2 (PF03089)    RAG2_PHD (PF13341)   
Domain families : Pfam (NCBI)pfam03089    pfam13341   
DMDM Disease mutations5897
Blocks (Seattle)P55895
Human Protein AtlasENSG00000175097
Peptide AtlasP55895
HPRD08913
IPIIPI00299162   IPI00984863   IPI00976391   
Protein Interaction databases
DIP (DOE-UCLA)P55895
IntAct (EBI)P55895
FunCoupENSG00000175097
BioGRIDRAG2
IntegromeDBRAG2
STRING (EMBL)RAG2
Ontologies - Pathways
QuickGOP55895
Ontology : AmiGOB cell lineage commitment  pre-B cell allelic exclusion  B cell homeostatic proliferation  T cell lineage commitment  DNA binding  chromatin binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  zinc ion binding  chromatin modification  B cell differentiation  T cell differentiation in thymus  V(D)J recombination  methylated histone binding  phosphatidylinositol binding  phosphatidylinositol-3,4-bisphosphate binding  positive regulation of organ growth  phosphatidylinositol-3,5-bisphosphate binding  
Ontology : EGO-EBIB cell lineage commitment  pre-B cell allelic exclusion  B cell homeostatic proliferation  T cell lineage commitment  DNA binding  chromatin binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  zinc ion binding  chromatin modification  B cell differentiation  T cell differentiation in thymus  V(D)J recombination  methylated histone binding  phosphatidylinositol binding  phosphatidylinositol-3,4-bisphosphate binding  positive regulation of organ growth  phosphatidylinositol-3,5-bisphosphate binding  
Pathways : KEGGFoxO signaling pathway    Primary immunodeficiency   
Protein Interaction DatabaseRAG2
DoCM (Curated mutations)RAG2
Wikipedia pathwaysRAG2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRAG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAG2
dbVarRAG2
ClinVarRAG2
1000_GenomesRAG2 
Exome Variant ServerRAG2
SNP (GeneSNP Utah)RAG2
SNP : HGBaseRAG2
Genetic variants : HAPMAPRAG2
Genomic VariantsRAG2  RAG2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000175097 
Somatic Mutations in Cancer : COSMICRAG2 
CONAN: Copy Number AnalysisRAG2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:36613493-36619829
Mutations and Diseases : HGMDRAG2
OMIM179616    233650    601457    603554   
MedgenRAG2
NextProtP55895 [Medical]
GENETestsRAG2
Disease Genetic AssociationRAG2
Huge Navigator RAG2 [HugePedia]  RAG2 [HugeCancerGEM]
snp3D : Map Gene to Disease5897
DGIdb (Drug Gene Interaction db)RAG2
General knowledge
Homologs : HomoloGeneRAG2
Homology/Alignments : Family Browser (UCSC)RAG2
Phylogenetic Trees/Animal Genes : TreeFamRAG2
Chemical/Protein Interactions : CTD5897
Chemical/Pharm GKB GenePA34186
Clinical trialRAG2
Cancer Resource (Charite)ENSG00000175097
Other databases
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
CoreMineRAG2
GoPubMedRAG2
iHOPRAG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 01:06:04 CET 2014

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