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RALA (v-ral simian leukemia viral oncogene homolog A (ras related))

Identity

Other namesRAL
HGNC (Hugo) RALA
LocusID (NCBI) 5898
Atlas_Id 42035
Location 7p14.1
Location_base_pair Starts at 39663152 and ends at 39747723 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RALA   9839
Cards
Entrez_Gene (NCBI)RALA  5898  v-ral simian leukemia viral oncogene homolog A (ras related)
GeneCards (Weizmann)RALA
Ensembl hg19 (Hinxton)ENSG00000006451 [Gene_View]  chr7:39663152-39747723 [Contig_View]  RALA [Vega]
Ensembl hg38 (Hinxton)ENSG00000006451 [Gene_View]  chr7:39663152-39747723 [Contig_View]  RALA [Vega]
ICGC DataPortalENSG00000006451
TCGA cBioPortalRALA
AceView (NCBI)RALA
Genatlas (Paris)RALA
WikiGenes5898
SOURCE (Princeton)RALA
Genomic and cartography
GoldenPath hg19 (UCSC)RALA  -     chr7:39663152-39747723 +  7p14.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RALA  -     7p14.1   [Description]    (hg38-Dec_2013)
EnsemblRALA - 7p14.1 [CytoView hg19]  RALA - 7p14.1 [CytoView hg38]
Mapping of homologs : NCBIRALA [Mapview hg19]  RALA [Mapview hg38]
OMIM179550   
Gene and transcription
Genbank (Entrez)AF086082 AF493910 AK026850 AK308109 AU132355
RefSeq transcript (Entrez)NM_005402
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)RALA
Cluster EST : UnigeneHs.6906 [ NCBI ]
CGAP (NCI)Hs.6906
Alternative Splicing : Fast-db (Paris)GSHG0027303
Alternative Splicing GalleryENSG00000006451
Gene ExpressionRALA [ NCBI-GEO ]     RALA [ SEEK ]   RALA [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11233 (Uniprot)
NextProtP11233  [Medical]  [Publications]
With graphics : InterProP11233
Splice isoforms : SwissVarP11233 (Swissvar)
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Ral    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Related proteins : CluSTrP11233
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAS (SM00173)  
DMDM Disease mutations5898
Blocks (Seattle)P11233
PDB (SRS)1UAD    1ZC3    1ZC4    2A78    2A9K    2BOV   
PDB (PDBSum)1UAD    1ZC3    1ZC4    2A78    2A9K    2BOV   
PDB (IMB)1UAD    1ZC3    1ZC4    2A78    2A9K    2BOV   
PDB (RSDB)1UAD    1ZC3    1ZC4    2A78    2A9K    2BOV   
Human Protein AtlasENSG00000006451
Peptide AtlasP11233
HPRD01549
IPIIPI00217519   IPI00927929   IPI00927712   
Protein Interaction databases
DIP (DOE-UCLA)P11233
IntAct (EBI)P11233
FunCoupENSG00000006451
BioGRIDRALA
IntegromeDBRALA
STRING (EMBL)RALA
Ontologies - Pathways
QuickGOP11233
Ontology : AmiGOcytokinesis  GTPase activity  protein binding  GTP binding  plasma membrane  focal adhesion  exocytosis  chemotaxis  signal transduction  Ras protein signal transduction  metabolic process  cell surface  viral process  myosin binding  regulation of exocytosis  GDP binding  endocytic vesicle  midbody  cytoplasmic vesicle membrane  actin cytoskeleton reorganization  ubiquitin protein ligase binding  Edg-2 lysophosphatidic acid receptor binding  cleavage furrow  neurotrophin TRK receptor signaling pathway  ATPase binding  positive regulation of filopodium assembly  membrane raft localization  membrane organization  extracellular exosome  
Ontology : EGO-EBIcytokinesis  GTPase activity  protein binding  GTP binding  plasma membrane  focal adhesion  exocytosis  chemotaxis  signal transduction  Ras protein signal transduction  metabolic process  cell surface  viral process  myosin binding  regulation of exocytosis  GDP binding  endocytic vesicle  midbody  cytoplasmic vesicle membrane  actin cytoskeleton reorganization  ubiquitin protein ligase binding  Edg-2 lysophosphatidic acid receptor binding  cleavage furrow  neurotrophin TRK receptor signaling pathway  ATPase binding  positive regulation of filopodium assembly  membrane raft localization  membrane organization  extracellular exosome  
Pathways : BIOCARTARas Signaling Pathway [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Pathways in cancer    Pancreatic cancer   
Protein Interaction DatabaseRALA
DoCM (Curated mutations)RALA
Wikipedia pathwaysRALA
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerRALA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RALA
dbVarRALA
ClinVarRALA
1000_GenomesRALA 
Exome Variant ServerRALA
SNP (GeneSNP Utah)RALA
SNP : HGBaseRALA
Genetic variants : HAPMAPRALA
Genomic Variants (DGV)RALA [DGVbeta]
Mutations
ICGC Data PortalRALA 
TCGA Data PortalRALA 
Tumor PortalRALA
Somatic Mutations in Cancer : COSMICRALA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:39663152-39747723
CONAN: Copy Number AnalysisRALA 
Mutations and Diseases : HGMDRALA
OMIM179550   
MedgenRALA
NextProtP11233 [Medical]
GENETestsRALA
Disease Genetic AssociationRALA
Huge Navigator RALA [HugePedia]  RALA [HugeCancerGEM]
snp3D : Map Gene to Disease5898
DGIdb (Drug Gene Interaction db)RALA
BioCentury BCIQRALA
General knowledge
Homologs : HomoloGeneRALA
Homology/Alignments : Family Browser (UCSC)RALA
Phylogenetic Trees/Animal Genes : TreeFamRALA
Chemical/Protein Interactions : CTD5898
Chemical/Pharm GKB GenePA34197
Clinical trialRALA
Cancer Resource (Charite)ENSG00000006451
Other databases
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
CoreMineRALA
GoPubMedRALA
iHOPRALA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 12:10:41 CEST 2015

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