RALA (RAS like proto-oncogene A)

2003-02-01  

Identity

HGNC
LOCATION
7p14.1
LOCUSID
ALIAS
HINCONS,RAL
FUSION GENES

Other Information

Locus ID:

NCBI: 5898
MIM: 179550
HGNC: 9839
Ensembl: ENSG00000006451

Variants:

dbSNP: 5898
ClinVar: 5898
TCGA: ENSG00000006451
COSMIC: RALA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006451ENST00000005257P11233
ENSG00000006451ENST00000434466H7C3P7
ENSG00000006451ENST00000436179C9JPE8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Pancreatic cancerKEGGko05212
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
p38MAPK eventsREACTOMER-HSA-171007
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159509032005Activation of RalA is critical for Ras-induced tumorigenesis of human cells.153
218222772011RALA and RALBP1 regulate mitochondrial fission at mitosis.128
171749142006Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.115
175401762007The tumor suppressor PP2A Abeta regulates the RalA GTPase.93
128560012003RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival.78
199010772010Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
177093812007Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.55
187562692008Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.52
176067112007Expression of ral GTPases, their effectors, and activators in human bladder cancer.46

Citation

Dessen P

RALA (RAS like proto-oncogene A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42035/rala