RALB (RAS like proto-oncogene B)

2003-02-01  

Identity

HGNC
LOCATION
2q14.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5899
MIM: 179551
HGNC: 9840
Ensembl: ENSG00000144118

Variants:

dbSNP: 5899
ClinVar: 5899
TCGA: ENSG00000144118
COSMIC: RALB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144118ENST00000272519P11234
ENSG00000144118ENST00000272519A0A024RAG3
ENSG00000144118ENST00000412383C9J6B1
ENSG00000144118ENST00000420510P11234
ENSG00000144118ENST00000420510A0A024RAG3
ENSG00000144118ENST00000431732F8WEQ6
ENSG00000144118ENST00000447591C9JQB3
ENSG00000144118ENST00000449649C9JYR1
ENSG00000144118ENST00000631312F8WEQ6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Pancreatic cancerKEGGko05212
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
p38MAPK eventsREACTOMER-HSA-171007
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170182832006RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.173
247474412014An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.128
212418942011RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.125
171749142006Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.115
128560012003RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
177093812007Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.55
187562692008Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.52
176067112007Expression of ral GTPases, their effectors, and activators in human bladder cancer.46
178759362007Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.39

Citation

Dessen P

RALB (RAS like proto-oncogene B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42036/ralb