RALBP1 (ralA binding protein 1)

2003-11-01  

Identity

HGNC
RALBP1
LOCATION
18p11.22
LOCUSID
10928
ALIAS
RIP1,RLIP1,RLIP76
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10928
MIM: 605801
HGNC: 9841
Ensembl: ENSG00000017797

Variants:

dbSNP: 10928
ClinVar: 10928
TCGA: ENSG00000017797
COSMIC: RALBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000017797ENST00000019317Q15311
ENSG00000017797ENST00000383432Q15311
ENSG00000017797ENST00000458039E7ENF8
ENSG00000017797ENST00000585015J3QLT3
ENSG00000017797ENST00000609094A0A1W2PRI7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pancreatic cancerKEGGko05212
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Ras signaling pathwayKEGGhsa04014
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448785carbamazepineChemicalPathwayassociated21738081
PA451879vincristineChemicalMultilinkAnnotation, Pathwayassociated27180762

References

Pubmed IDYearTitleCitations
218222772011RALA and RALBP1 regulate mitochondrial fission at mitosis.128
170471552007Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.58
127757242003RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.55
184746072008Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1.34
186284502008RLIP76 and Cancer.30
179820772007Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.29
194171342009RLIP76: a target for kidney cancer therapy.27
196265872010Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.27
179936112008Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis.24
211702622010RalBP1 is necessary for metastasis of human cancer cell lines.24

Citation

Dessen P

RALBP1 (ralA binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42037/ralbp1