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RALGAPA1 (Ral GTPase activating protein, alpha subunit 1 (catalytic))

Identity

Alias_namesGARNL1
GTPase activating RANGAP domain-like 1
GTPase activating Rap/RanGAP domain-like 1
Alias_symbol (synonym)GRIPE
DKFZp667F074
KIAA0884
Tulip1
RalGAPalpha1
Other aliasTULIP1
p240
HGNC (Hugo) RALGAPA1
LocusID (NCBI) 253959
Atlas_Id 72476
Location 14q13.2  [Link to chromosome band 14q13]
Location_base_pair Starts at 36007558 and ends at 36278432 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RALGAPA1 (14q13.2) / PRRC2B (9q34.13)RALGAPA1 (14q13.2) / SLC25A21 (14q13.3)SEPT3 (22q13.2) / RALGAPA1 (14q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RALGAPA1   17770
Cards
Entrez_Gene (NCBI)RALGAPA1  253959  Ral GTPase activating protein, alpha subunit 1 (catalytic)
AliasesGARNL1; GRIPE; RalGAPalpha1; TULIP1; 
p240
GeneCards (Weizmann)RALGAPA1
Ensembl hg19 (Hinxton)ENSG00000174373 [Gene_View]  chr14:36007558-36278432 [Contig_View]  RALGAPA1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000174373 [Gene_View]  chr14:36007558-36278432 [Contig_View]  RALGAPA1 [Vega]
ICGC DataPortalENSG00000174373
TCGA cBioPortalRALGAPA1
AceView (NCBI)RALGAPA1
Genatlas (Paris)RALGAPA1
WikiGenes253959
SOURCE (Princeton)RALGAPA1
Genetics Home Reference (NIH)RALGAPA1
Genomic and cartography
GoldenPath hg19 (UCSC)RALGAPA1  -     chr14:36007558-36278432 -  14q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RALGAPA1  -     14q13.2   [Description]    (hg38-Dec_2013)
EnsemblRALGAPA1 - 14q13.2 [CytoView hg19]  RALGAPA1 - 14q13.2 [CytoView hg38]
Mapping of homologs : NCBIRALGAPA1 [Mapview hg19]  RALGAPA1 [Mapview hg38]
OMIM608884   
Gene and transcription
Genbank (Entrez)AB020691 AB511280 AK022988 AK126975 AL834362
RefSeq transcript (Entrez)NM_001283043 NM_001283044 NM_014990 NM_194301
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)RALGAPA1
Cluster EST : UnigeneHs.113150 [ NCBI ]
CGAP (NCI)Hs.113150
Alternative Splicing GalleryENSG00000174373
Gene ExpressionRALGAPA1 [ NCBI-GEO ]   RALGAPA1 [ EBI - ARRAY_EXPRESS ]   RALGAPA1 [ SEEK ]   RALGAPA1 [ MEM ]
Gene Expression Viewer (FireBrowse)RALGAPA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)253959
GTEX Portal (Tissue expression)RALGAPA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6GYQ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6GYQ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6GYQ0
Splice isoforms : SwissVarQ6GYQ0
PhosPhoSitePlusQ6GYQ0
Domaine pattern : Prosite (Expaxy)RAPGAP (PS50085)   
Domains : Interpro (EBI)ARM-type_fold    Rap_GAP_dom   
Domain families : Pfam (Sanger)Rap_GAP (PF02145)   
Domain families : Pfam (NCBI)pfam02145   
Conserved Domain (NCBI)RALGAPA1
DMDM Disease mutations253959
Blocks (Seattle)RALGAPA1
SuperfamilyQ6GYQ0
Human Protein AtlasENSG00000174373
Peptide AtlasQ6GYQ0
HPRD12324
IPIIPI00472044   IPI00456722   IPI00646904   IPI00744251   IPI00456723   IPI00783865   IPI01015672   IPI01015297   IPI01018323   
Protein Interaction databases
DIP (DOE-UCLA)Q6GYQ0
IntAct (EBI)Q6GYQ0
FunCoupENSG00000174373
BioGRIDRALGAPA1
STRING (EMBL)RALGAPA1
ZODIACRALGAPA1
Ontologies - Pathways
QuickGOQ6GYQ0
Ontology : AmiGOGTPase activator activity  GTPase activator activity  nucleus  cytoplasm  cytoplasm  regulation of transcription, DNA-templated  protein heterodimerization activity  activation of GTPase activity  activation of GTPase activity  
Ontology : EGO-EBIGTPase activator activity  GTPase activator activity  nucleus  cytoplasm  cytoplasm  regulation of transcription, DNA-templated  protein heterodimerization activity  activation of GTPase activity  activation of GTPase activity  
NDEx NetworkRALGAPA1
Atlas of Cancer Signalling NetworkRALGAPA1
Wikipedia pathwaysRALGAPA1
Orthology - Evolution
OrthoDB253959
GeneTree (enSembl)ENSG00000174373
Phylogenetic Trees/Animal Genes : TreeFamRALGAPA1
HOVERGENQ6GYQ0
HOGENOMQ6GYQ0
Homologs : HomoloGeneRALGAPA1
Homology/Alignments : Family Browser (UCSC)RALGAPA1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRALGAPA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RALGAPA1
dbVarRALGAPA1
ClinVarRALGAPA1
1000_GenomesRALGAPA1 
Exome Variant ServerRALGAPA1
ExAC (Exome Aggregation Consortium)RALGAPA1 (select the gene name)
Genetic variants : HAPMAP253959
Genomic Variants (DGV)RALGAPA1 [DGVbeta]
DECIPHER (Syndromes)14:36007558-36278432  ENSG00000174373
CONAN: Copy Number AnalysisRALGAPA1 
Mutations
ICGC Data PortalRALGAPA1 
TCGA Data PortalRALGAPA1 
Broad Tumor PortalRALGAPA1
OASIS PortalRALGAPA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRALGAPA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRALGAPA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RALGAPA1
DgiDB (Drug Gene Interaction Database)RALGAPA1
DoCM (Curated mutations)RALGAPA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RALGAPA1 (select a term)
intoGenRALGAPA1
Cancer3DRALGAPA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608884   
Orphanet
MedgenRALGAPA1
Genetic Testing Registry RALGAPA1
NextProtQ6GYQ0 [Medical]
TSGene253959
GENETestsRALGAPA1
Huge Navigator RALGAPA1 [HugePedia]
snp3D : Map Gene to Disease253959
BioCentury BCIQRALGAPA1
ClinGenRALGAPA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD253959
Chemical/Pharm GKB GenePA165479278
Clinical trialRALGAPA1
Miscellaneous
canSAR (ICR)RALGAPA1 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRALGAPA1
EVEXRALGAPA1
GoPubMedRALGAPA1
iHOPRALGAPA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:40:29 CET 2017

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