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RALGAPA2 (Ral GTPase activating protein catalytic alpha subunit 2)

Identity

Alias_namesC20orf74
chromosome 20 open reading frame 74
Alias_symbol (synonym)dJ1049G11.4
AS250
KIAA1272
RapGAPalpha2
Other aliasbA287B20.1
dJ1049G11
p220
HGNC (Hugo) RALGAPA2
LocusID (NCBI) 57186
Atlas_Id 53283
Location 20p11.23  [Link to chromosome band 20p11]
Location_base_pair Starts at 20389628 and ends at 20712623 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CFAP52 (17p13.1) / RALGAPA2 (20p11.23)DTD1 (20p11.23) / RALGAPA2 (20p11.23)IGFBP5 (2q35) / RALGAPA2 (20p11.23)
METTL8 (2q31.1) / RALGAPA2 (20p11.23)NCOA6 (20q11.22) / RALGAPA2 (20p11.23)RALGAPA2 (20p11.23) / CNTFR (9p13.3)
RALGAPA2 (20p11.23) / LARGE (22q12.3)RPRD1A (18q12.2) / RALGAPA2 (20p11.23)TMEM132D (12q24.33) / RALGAPA2 (20p11.23)
DTD1 20p11.23 / RALGAPA2 20p11.23NCOA6 20q11.22 / RALGAPA2 20p11.23RPRD1A 18q12.2 / RALGAPA2 20p11.23
TMEM132D 12q24.33 / RALGAPA2 20p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RALGAPA2   16207
Cards
Entrez_Gene (NCBI)RALGAPA2  57186  Ral GTPase activating protein catalytic alpha subunit 2
AliasesAS250; C20orf74; bA287B20.1; dJ1049G11; 
dJ1049G11.4; p220
GeneCards (Weizmann)RALGAPA2
Ensembl hg19 (Hinxton)ENSG00000188559 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188559 [Gene_View]  chr20:20389628-20712623 [Contig_View]  RALGAPA2 [Vega]
ICGC DataPortalENSG00000188559
TCGA cBioPortalRALGAPA2
AceView (NCBI)RALGAPA2
Genatlas (Paris)RALGAPA2
WikiGenes57186
SOURCE (Princeton)RALGAPA2
Genetics Home Reference (NIH)RALGAPA2
Genomic and cartography
GoldenPath hg38 (UCSC)RALGAPA2  -     chr20:20389628-20712623 -  20p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RALGAPA2  -     20p11.23   [Description]    (hg19-Feb_2009)
EnsemblRALGAPA2 - 20p11.23 [CytoView hg19]  RALGAPA2 - 20p11.23 [CytoView hg38]
Mapping of homologs : NCBIRALGAPA2 [Mapview hg19]  RALGAPA2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK002211 AK022881 AK026194 AK127228 AY007097
RefSeq transcript (Entrez)NM_020343
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RALGAPA2
Cluster EST : UnigeneHs.472285 [ NCBI ]
CGAP (NCI)Hs.472285
Alternative Splicing GalleryENSG00000188559
Gene ExpressionRALGAPA2 [ NCBI-GEO ]   RALGAPA2 [ EBI - ARRAY_EXPRESS ]   RALGAPA2 [ SEEK ]   RALGAPA2 [ MEM ]
Gene Expression Viewer (FireBrowse)RALGAPA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57186
GTEX Portal (Tissue expression)RALGAPA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ2PPJ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ2PPJ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ2PPJ7
Splice isoforms : SwissVarQ2PPJ7
PhosPhoSitePlusQ2PPJ7
Domaine pattern : Prosite (Expaxy)RAPGAP (PS50085)   
Domains : Interpro (EBI)ARM-type_fold    Rap_GAP_dom   
Domain families : Pfam (Sanger)Rap_GAP (PF02145)   
Domain families : Pfam (NCBI)pfam02145   
Conserved Domain (NCBI)RALGAPA2
DMDM Disease mutations57186
Blocks (Seattle)RALGAPA2
SuperfamilyQ2PPJ7
Human Protein AtlasENSG00000188559
Peptide AtlasQ2PPJ7
IPIIPI00790553   IPI00552470   IPI00455174   IPI01010075   IPI00607862   IPI00645062   
Protein Interaction databases
DIP (DOE-UCLA)Q2PPJ7
IntAct (EBI)Q2PPJ7
FunCoupENSG00000188559
BioGRIDRALGAPA2
STRING (EMBL)RALGAPA2
ZODIACRALGAPA2
Ontologies - Pathways
QuickGOQ2PPJ7
Ontology : AmiGOGTPase activator activity  GTPase activator activity  extracellular space  cytoplasm  cytosol  plasma membrane  protein heterodimerization activity  regulation of small GTPase mediated signal transduction  activation of GTPase activity  activation of GTPase activity  
Ontology : EGO-EBIGTPase activator activity  GTPase activator activity  extracellular space  cytoplasm  cytosol  plasma membrane  protein heterodimerization activity  regulation of small GTPase mediated signal transduction  activation of GTPase activity  activation of GTPase activity  
NDEx NetworkRALGAPA2
Atlas of Cancer Signalling NetworkRALGAPA2
Wikipedia pathwaysRALGAPA2
Orthology - Evolution
OrthoDB57186
GeneTree (enSembl)ENSG00000188559
Phylogenetic Trees/Animal Genes : TreeFamRALGAPA2
HOVERGENQ2PPJ7
HOGENOMQ2PPJ7
Homologs : HomoloGeneRALGAPA2
Homology/Alignments : Family Browser (UCSC)RALGAPA2
Gene fusions - Rearrangements
Fusion : MitelmanDTD1/RALGAPA2 [20p11.23/20p11.23]  [t(20;20)(p11;p11)]  
Fusion : MitelmanNCOA6/RALGAPA2 [20q11.22/20p11.23]  [t(20;20)(p11;q11)]  
Fusion : MitelmanRPRD1A/RALGAPA2 [18q12.2/20p11.23]  [t(18;20)(q12;p11)]  
Fusion : MitelmanTMEM132D/RALGAPA2 [12q24.33/20p11.23]  [t(12;20)(q24;p11)]  
Fusion: TCGADTD1 20p11.23 RALGAPA2 20p11.23 HNSC
Fusion: TCGANCOA6 20q11.22 RALGAPA2 20p11.23 BRCA
Fusion: TCGARPRD1A 18q12.2 RALGAPA2 20p11.23 BRCA
Fusion: TCGATMEM132D 12q24.33 RALGAPA2 20p11.23 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRALGAPA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RALGAPA2
dbVarRALGAPA2
ClinVarRALGAPA2
1000_GenomesRALGAPA2 
Exome Variant ServerRALGAPA2
ExAC (Exome Aggregation Consortium)RALGAPA2 (select the gene name)
Genetic variants : HAPMAP57186
Genomic Variants (DGV)RALGAPA2 [DGVbeta]
DECIPHERRALGAPA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRALGAPA2 
Mutations
ICGC Data PortalRALGAPA2 
TCGA Data PortalRALGAPA2 
Broad Tumor PortalRALGAPA2
OASIS PortalRALGAPA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRALGAPA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRALGAPA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RALGAPA2
DgiDB (Drug Gene Interaction Database)RALGAPA2
DoCM (Curated mutations)RALGAPA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RALGAPA2 (select a term)
intoGenRALGAPA2
Cancer3DRALGAPA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenRALGAPA2
Genetic Testing Registry RALGAPA2
NextProtQ2PPJ7 [Medical]
TSGene57186
GENETestsRALGAPA2
Target ValidationRALGAPA2
Huge Navigator RALGAPA2 [HugePedia]
snp3D : Map Gene to Disease57186
BioCentury BCIQRALGAPA2
ClinGenRALGAPA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57186
Chemical/Pharm GKB GenePA25784
Clinical trialRALGAPA2
Miscellaneous
canSAR (ICR)RALGAPA2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRALGAPA2
EVEXRALGAPA2
GoPubMedRALGAPA2
iHOPRALGAPA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:52:27 CEST 2017

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