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RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2)

Identity

Alias (NCBI)AS250
C20orf74
bA287B20.1
dJ1049G11
dJ1049G11.4
p220
HGNC (Hugo) RALGAPA2
HGNC Alias symbdJ1049G11.4
AS250
KIAA1272
RapGAPalpha2
HGNC Previous nameC20orf74
HGNC Previous namechromosome 20 open reading frame 74
LocusID (NCBI) 57186
Atlas_Id 53283
Location 20p11.23  [Link to chromosome band 20p11]
Location_base_pair Starts at 20389530 and ends at 20712644 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CFAP52 (17p13.1) / RALGAPA2 (20p11.23)DTD1 (20p11.23) / RALGAPA2 (20p11.23)IGFBP5 (2q35) / RALGAPA2 (20p11.23)
METTL8 (2q31.1) / RALGAPA2 (20p11.23)NCOA6 (20q11.22) / RALGAPA2 (20p11.23)RALGAPA2 (20p11.23) / CNTFR (9p13.3)
RALGAPA2 (20p11.23) / LARGE (22q12.3)RPRD1A (18q12.2) / RALGAPA2 (20p11.23)TMEM132D (12q24.33) / RALGAPA2 (20p11.23)
DTD1 20p11.23 / RALGAPA2 20p11.23NCOA6 20q11.22 / RALGAPA2 20p11.23RPRD1A 18q12.2 / RALGAPA2 20p11.23
TMEM132D 12q24.33 / RALGAPA2 20p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RALGAPA2   16207
Cards
Entrez_Gene (NCBI)RALGAPA2    Ral GTPase activating protein catalytic subunit alpha 2
AliasesAS250; C20orf74; bA287B20.1; dJ1049G11; 
dJ1049G11.4; p220
GeneCards (Weizmann)RALGAPA2
Ensembl hg19 (Hinxton)ENSG00000188559 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188559 [Gene_View]  ENSG00000188559 [Sequence]  chr20:20389530-20712644 [Contig_View]  RALGAPA2 [Vega]
ICGC DataPortalENSG00000188559
TCGA cBioPortalRALGAPA2
AceView (NCBI)RALGAPA2
Genatlas (Paris)RALGAPA2
SOURCE (Princeton)RALGAPA2
Genetics Home Reference (NIH)RALGAPA2
Genomic and cartography
GoldenPath hg38 (UCSC)RALGAPA2  -     chr20:20389530-20712644 -  20p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RALGAPA2  -     20p11.23   [Description]    (hg19-Feb_2009)
GoldenPathRALGAPA2 - 20p11.23 [CytoView hg19]  RALGAPA2 - 20p11.23 [CytoView hg38]
ImmunoBaseENSG00000188559
Genome Data Viewer NCBIRALGAPA2 [Mapview hg19]  
OMIM618836   
Gene and transcription
Genbank (Entrez)AK002211 AK022881 AK026194 AK127228 AY007097
RefSeq transcript (Entrez)NM_020343
Consensus coding sequences : CCDS (NCBI)RALGAPA2
Gene ExpressionRALGAPA2 [ NCBI-GEO ]   RALGAPA2 [ EBI - ARRAY_EXPRESS ]   RALGAPA2 [ SEEK ]   RALGAPA2 [ MEM ]
Gene Expression Viewer (FireBrowse)RALGAPA2 [ Firebrowse - Broad ]
GenevisibleExpression of RALGAPA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57186
GTEX Portal (Tissue expression)RALGAPA2
Human Protein AtlasENSG00000188559-RALGAPA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ2PPJ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ2PPJ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ2PPJ7
PhosPhoSitePlusQ2PPJ7
Domaine pattern : Prosite (Expaxy)RAPGAP (PS50085)   
Domains : Interpro (EBI)ARM-type_fold    Rap/Ran-GAP_sf    Rap_GAP_dom    Tuberin/Ral-act_asu   
Domain families : Pfam (Sanger)Rap_GAP (PF02145)   
Domain families : Pfam (NCBI)pfam02145   
Conserved Domain (NCBI)RALGAPA2
SuperfamilyQ2PPJ7
AlphaFold pdb e-kbQ2PPJ7   
Human Protein Atlas [tissue]ENSG00000188559-RALGAPA2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q2PPJ7
IntAct (EBI)Q2PPJ7
BioGRIDRALGAPA2
STRING (EMBL)RALGAPA2
ZODIACRALGAPA2
Ontologies - Pathways
QuickGOQ2PPJ7
Ontology : AmiGOGTPase activator activity  GTPase activator activity  extracellular space  nucleus  cytoplasm  cytoplasm  cytosol  plasma membrane  protein heterodimerization activity  regulation of small GTPase mediated signal transduction  activation of GTPase activity  
Ontology : EGO-EBIGTPase activator activity  GTPase activator activity  extracellular space  nucleus  cytoplasm  cytoplasm  cytosol  plasma membrane  protein heterodimerization activity  regulation of small GTPase mediated signal transduction  activation of GTPase activity  
NDEx NetworkRALGAPA2
Atlas of Cancer Signalling NetworkRALGAPA2
Wikipedia pathwaysRALGAPA2
Orthology - Evolution
OrthoDB57186
GeneTree (enSembl)ENSG00000188559
Phylogenetic Trees/Animal Genes : TreeFamRALGAPA2
Homologs : HomoloGeneRALGAPA2
Homology/Alignments : Family Browser (UCSC)RALGAPA2
Gene fusions - Rearrangements
Fusion : MitelmanDTD1/RALGAPA2 [20p11.23/20p11.23]  
Fusion : MitelmanNCOA6/RALGAPA2 [20q11.22/20p11.23]  
Fusion : MitelmanRPRD1A/RALGAPA2 [18q12.2/20p11.23]  
Fusion : MitelmanTMEM132D/RALGAPA2 [12q24.33/20p11.23]  
Fusion : QuiverRALGAPA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRALGAPA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RALGAPA2
dbVarRALGAPA2
ClinVarRALGAPA2
MonarchRALGAPA2
1000_GenomesRALGAPA2 
Exome Variant ServerRALGAPA2
GNOMAD BrowserENSG00000188559
Varsome BrowserRALGAPA2
ACMGRALGAPA2 variants
VarityQ2PPJ7
Genomic Variants (DGV)RALGAPA2 [DGVbeta]
DECIPHERRALGAPA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRALGAPA2 
Mutations
ICGC Data PortalRALGAPA2 
TCGA Data PortalRALGAPA2 
Broad Tumor PortalRALGAPA2
OASIS PortalRALGAPA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRALGAPA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRALGAPA2
Mutations and Diseases : HGMDRALGAPA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRALGAPA2
DgiDB (Drug Gene Interaction Database)RALGAPA2
DoCM (Curated mutations)RALGAPA2
CIViC (Clinical Interpretations of Variants in Cancer)RALGAPA2
Cancer3DRALGAPA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618836   
Orphanet
DisGeNETRALGAPA2
MedgenRALGAPA2
Genetic Testing Registry RALGAPA2
NextProtQ2PPJ7 [Medical]
GENETestsRALGAPA2
Target ValidationRALGAPA2
Huge Navigator RALGAPA2 [HugePedia]
ClinGenRALGAPA2
Clinical trials, drugs, therapy
MyCancerGenomeRALGAPA2
Protein Interactions : CTDRALGAPA2
Pharm GKB GenePA25784
PharosQ2PPJ7
Clinical trialRALGAPA2
Miscellaneous
canSAR (ICR)RALGAPA2
HarmonizomeRALGAPA2
DataMed IndexRALGAPA2
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRALGAPA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:28:09 CEST 2021

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