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RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2)

Identity

Alias (NCBI)dJ595C2.1
HGNC (Hugo) RALGPS2
HGNC Alias symbKIAA0351
FLJ10244
FLJ25604
LocusID (NCBI) 55103
Atlas_Id 47435
Location 1q25.2  [Link to chromosome band 1q25]
Location_base_pair Starts at 178725244 and ends at 178921840 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DLG2 (11q14.1) / RALGPS2 (1q25.2)HLA-DQA1 (6p21.32) / RALGPS2 (1q25.2)RALGPS2 (1q25.2) / LAMB3 (1q32.2)
RALGPS2 (1q25.2) / RALGPS2 (1q25.2)RALGPS2 (1q25.2) / SLC22A17 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q25;q32) RALGPS2/LAMB3


External links

Nomenclature
HGNC (Hugo)RALGPS2   30279
Cards
Entrez_Gene (NCBI)RALGPS2    Ral GEF with PH domain and SH3 binding motif 2
AliasesdJ595C2.1
GeneCards (Weizmann)RALGPS2
Ensembl hg19 (Hinxton)ENSG00000116191 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116191 [Gene_View]  ENSG00000116191 [Sequence]  chr1:178725244-178921840 [Contig_View]  RALGPS2 [Vega]
ICGC DataPortalENSG00000116191
TCGA cBioPortalRALGPS2
AceView (NCBI)RALGPS2
Genatlas (Paris)RALGPS2
SOURCE (Princeton)RALGPS2
Genetics Home Reference (NIH)RALGPS2
Genomic and cartography
GoldenPath hg38 (UCSC)RALGPS2  -     chr1:178725244-178921840 +  1q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RALGPS2  -     1q25.2   [Description]    (hg19-Feb_2009)
GoldenPathRALGPS2 - 1q25.2 [CytoView hg19]  RALGPS2 - 1q25.2 [CytoView hg38]
ImmunoBaseENSG00000116191
genome Data Viewer NCBIRALGPS2 [Mapview hg19]  
OMIM617819   
Gene and transcription
Genbank (Entrez)AK001106 AK098470 AK301753 BC045691 BC047391
RefSeq transcript (Entrez)NM_001286247 NM_018037 NM_152663
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RALGPS2
Alternative Splicing GalleryENSG00000116191
Gene ExpressionRALGPS2 [ NCBI-GEO ]   RALGPS2 [ EBI - ARRAY_EXPRESS ]   RALGPS2 [ SEEK ]   RALGPS2 [ MEM ]
Gene Expression Viewer (FireBrowse)RALGPS2 [ Firebrowse - Broad ]
GenevisibleExpression of RALGPS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55103
GTEX Portal (Tissue expression)RALGPS2
Human Protein AtlasENSG00000116191-RALGPS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86X27   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86X27  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86X27
Splice isoforms : SwissVarQ86X27
PhosPhoSitePlusQ86X27
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RASGEF_CAT (PS50009)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    RalGPS1/2    Ras-like_GEF    Ras_GEF_dom_sf    RASGEF_cat_dom    RASGEF_cat_dom_sf   
Domain families : Pfam (Sanger)PH (PF00169)    RasGEF (PF00617)   
Domain families : Pfam (NCBI)pfam00169    pfam00617   
Domain families : Smart (EMBL)PH (SM00233)  RasGEF (SM00147)  
Conserved Domain (NCBI)RALGPS2
Blocks (Seattle)RALGPS2
SuperfamilyQ86X27
Human Protein Atlas [tissue]ENSG00000116191-RALGPS2 [tissue]
Peptide AtlasQ86X27
HPRD15206
IPIIPI00334126   IPI00514928   IPI00644990   IPI00926328   
Protein Interaction databases
DIP (DOE-UCLA)Q86X27
IntAct (EBI)Q86X27
BioGRIDRALGPS2
STRING (EMBL)RALGPS2
ZODIACRALGPS2
Ontologies - Pathways
QuickGOQ86X27
Ontology : AmiGOguanyl-nucleotide exchange factor activity  cytoplasm  plasma membrane  small GTPase mediated signal transduction  regulation of Ral protein signal transduction  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  cytoplasm  plasma membrane  small GTPase mediated signal transduction  regulation of Ral protein signal transduction  
NDEx NetworkRALGPS2
Atlas of Cancer Signalling NetworkRALGPS2
Wikipedia pathwaysRALGPS2
Orthology - Evolution
OrthoDB55103
GeneTree (enSembl)ENSG00000116191
Phylogenetic Trees/Animal Genes : TreeFamRALGPS2
HOGENOMQ86X27
Homologs : HomoloGeneRALGPS2
Homology/Alignments : Family Browser (UCSC)RALGPS2
Gene fusions - Rearrangements
Fusion : MitelmanRALGPS2/LAMB3 [1q25.2/1q32.2]  
Fusion Cancer (Beijing)HLA-DQA1 [6p21.32]  -  RALGPS2 [1q25.2]  [FUSC000097]
Fusion : QuiverRALGPS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRALGPS2 [hg38]
dbVarRALGPS2
ClinVarRALGPS2
MonarchRALGPS2
1000_GenomesRALGPS2 
Exome Variant ServerRALGPS2
GNOMAD BrowserENSG00000116191
Varsome BrowserRALGPS2
Genomic Variants (DGV)RALGPS2 [DGVbeta]
DECIPHERRALGPS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRALGPS2 
Mutations
ICGC Data PortalRALGPS2 
TCGA Data PortalRALGPS2 
Broad Tumor PortalRALGPS2
OASIS PortalRALGPS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRALGPS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRALGPS2
Mutations and Diseases : HGMDRALGPS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RALGPS2
DgiDB (Drug Gene Interaction Database)RALGPS2
DoCM (Curated mutations)RALGPS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RALGPS2 (select a term)
intoGenRALGPS2
Cancer3DRALGPS2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617819   
Orphanet
DisGeNETRALGPS2
MedgenRALGPS2
Genetic Testing Registry RALGPS2
NextProtQ86X27 [Medical]
GENETestsRALGPS2
Target ValidationRALGPS2
Huge Navigator RALGPS2 [HugePedia]
ClinGenRALGPS2
Clinical trials, drugs, therapy
MyCancerGenomeRALGPS2
Protein Interactions : CTD
Pharm GKB GenePA134864387
PharosQ86X27
Clinical trialRALGPS2
Miscellaneous
canSAR (ICR)RALGPS2 (select the gene name)
HarmonizomeRALGPS2
DataMed IndexRALGPS2
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRALGPS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:34:18 CET 2021

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