Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2)

Identity

Alias_symbol (synonym)KIAA0351
FLJ10244
FLJ25604
Other aliasdJ595C2.1
HGNC (Hugo) RALGPS2
LocusID (NCBI) 55103
Atlas_Id 47435
Location 1q25.2  [Link to chromosome band 1q25]
Location_base_pair Starts at 178725147 and ends at 178921842 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DLG2 (11q14.1) / RALGPS2 (1q25.2)HLA-DQA1 (6p21.32) / RALGPS2 (1q25.2)RALGPS2 (1q25.2) / LAMB3 (1q32.2)
RALGPS2 (1q25.2) / RALGPS2 (1q25.2)RALGPS2 (1q25.2) / SLC22A17 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RALGPS2   30279
Cards
Entrez_Gene (NCBI)RALGPS2  55103  Ral GEF with PH domain and SH3 binding motif 2
AliasesdJ595C2.1
GeneCards (Weizmann)RALGPS2
Ensembl hg19 (Hinxton)ENSG00000116191 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116191 [Gene_View]  chr1:178725147-178921842 [Contig_View]  RALGPS2 [Vega]
ICGC DataPortalENSG00000116191
TCGA cBioPortalRALGPS2
AceView (NCBI)RALGPS2
Genatlas (Paris)RALGPS2
WikiGenes55103
SOURCE (Princeton)RALGPS2
Genetics Home Reference (NIH)RALGPS2
Genomic and cartography
GoldenPath hg38 (UCSC)RALGPS2  -     chr1:178725147-178921842 +  1q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RALGPS2  -     1q25.2   [Description]    (hg19-Feb_2009)
EnsemblRALGPS2 - 1q25.2 [CytoView hg19]  RALGPS2 - 1q25.2 [CytoView hg38]
Mapping of homologs : NCBIRALGPS2 [Mapview hg19]  RALGPS2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK001106 AK098470 AK301753 BC045691 BC047391
RefSeq transcript (Entrez)NM_001286247 NM_018037 NM_152663
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RALGPS2
Cluster EST : UnigeneHs.657592 [ NCBI ]
CGAP (NCI)Hs.657592
Alternative Splicing GalleryENSG00000116191
Gene ExpressionRALGPS2 [ NCBI-GEO ]   RALGPS2 [ EBI - ARRAY_EXPRESS ]   RALGPS2 [ SEEK ]   RALGPS2 [ MEM ]
Gene Expression Viewer (FireBrowse)RALGPS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55103
GTEX Portal (Tissue expression)RALGPS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86X27   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86X27  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86X27
Splice isoforms : SwissVarQ86X27
PhosPhoSitePlusQ86X27
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RASGEF_CAT (PS50009)   
Domains : Interpro (EBI)PH_dom-like    PH_domain    RalGPS1/2    Ras_GEF_dom    RASGEF_cat_dom   
Domain families : Pfam (Sanger)PH (PF00169)    RasGEF (PF00617)   
Domain families : Pfam (NCBI)pfam00169    pfam00617   
Domain families : Smart (EMBL)PH (SM00233)  RasGEF (SM00147)  
Conserved Domain (NCBI)RALGPS2
DMDM Disease mutations55103
Blocks (Seattle)RALGPS2
SuperfamilyQ86X27
Human Protein AtlasENSG00000116191
Peptide AtlasQ86X27
HPRD15206
IPIIPI00334126   IPI00514928   IPI00644990   IPI00926328   
Protein Interaction databases
DIP (DOE-UCLA)Q86X27
IntAct (EBI)Q86X27
FunCoupENSG00000116191
BioGRIDRALGPS2
STRING (EMBL)RALGPS2
ZODIACRALGPS2
Ontologies - Pathways
QuickGOQ86X27
Ontology : AmiGOguanyl-nucleotide exchange factor activity  cytoplasm  plasma membrane  small GTPase mediated signal transduction  regulation of Ral protein signal transduction  positive regulation of GTPase activity  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  cytoplasm  plasma membrane  small GTPase mediated signal transduction  regulation of Ral protein signal transduction  positive regulation of GTPase activity  
NDEx NetworkRALGPS2
Atlas of Cancer Signalling NetworkRALGPS2
Wikipedia pathwaysRALGPS2
Orthology - Evolution
OrthoDB55103
GeneTree (enSembl)ENSG00000116191
Phylogenetic Trees/Animal Genes : TreeFamRALGPS2
HOVERGENQ86X27
HOGENOMQ86X27
Homologs : HomoloGeneRALGPS2
Homology/Alignments : Family Browser (UCSC)RALGPS2
Gene fusions - Rearrangements
Fusion : MitelmanRALGPS2/LAMB3 [1q25.2/1q32.2]  
Fusion Cancer (Beijing)HLA-DQA1 [6p21.32]  -  RALGPS2 [1q25.2]  [FUSC000097]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRALGPS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RALGPS2
dbVarRALGPS2
ClinVarRALGPS2
1000_GenomesRALGPS2 
Exome Variant ServerRALGPS2
ExAC (Exome Aggregation Consortium)RALGPS2 (select the gene name)
Genetic variants : HAPMAP55103
Genomic Variants (DGV)RALGPS2 [DGVbeta]
DECIPHERRALGPS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRALGPS2 
Mutations
ICGC Data PortalRALGPS2 
TCGA Data PortalRALGPS2 
Broad Tumor PortalRALGPS2
OASIS PortalRALGPS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRALGPS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRALGPS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RALGPS2
DgiDB (Drug Gene Interaction Database)RALGPS2
DoCM (Curated mutations)RALGPS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RALGPS2 (select a term)
intoGenRALGPS2
Cancer3DRALGPS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenRALGPS2
Genetic Testing Registry RALGPS2
NextProtQ86X27 [Medical]
TSGene55103
GENETestsRALGPS2
Target ValidationRALGPS2
Huge Navigator RALGPS2 [HugePedia]
snp3D : Map Gene to Disease55103
BioCentury BCIQRALGPS2
ClinGenRALGPS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55103
Chemical/Pharm GKB GenePA134864387
Clinical trialRALGPS2
Miscellaneous
canSAR (ICR)RALGPS2 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRALGPS2
EVEXRALGPS2
GoPubMedRALGPS2
iHOPRALGPS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:05:18 CEST 2017

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