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RAMP2 (receptor activity modifying protein 2)

Identity

Alias_namesreceptor activity modifying protein 2
receptor (calcitonin) activity modifying protein 2
receptor (G protein-coupled) activity modifying protein 2
Other alias-
HGNC (Hugo) RAMP2
LocusID (NCBI) 10266
Atlas_Id 49831
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42761194 and ends at 42763041 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NPHP1 (2q13) / RAMP2 (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAMP2   9844
Cards
Entrez_Gene (NCBI)RAMP2  10266  receptor activity modifying protein 2
Aliases
GeneCards (Weizmann)RAMP2
Ensembl hg19 (Hinxton)ENSG00000131477 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131477 [Gene_View]  chr17:42761194-42763041 [Contig_View]  RAMP2 [Vega]
ICGC DataPortalENSG00000131477
TCGA cBioPortalRAMP2
AceView (NCBI)RAMP2
Genatlas (Paris)RAMP2
WikiGenes10266
SOURCE (Princeton)RAMP2
Genetics Home Reference (NIH)RAMP2
Genomic and cartography
GoldenPath hg38 (UCSC)RAMP2  -     chr17:42761194-42763041 +  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAMP2  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblRAMP2 - 17q21.2 [CytoView hg19]  RAMP2 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIRAMP2 [Mapview hg19]  RAMP2 [Mapview hg38]
OMIM605154   
Gene and transcription
Genbank (Entrez)AJ001015 AL548945 AY265458 BC027975 DQ893321
RefSeq transcript (Entrez)NM_005854
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAMP2
Cluster EST : UnigeneHs.514193 [ NCBI ]
CGAP (NCI)Hs.514193
Alternative Splicing GalleryENSG00000131477
Gene ExpressionRAMP2 [ NCBI-GEO ]   RAMP2 [ EBI - ARRAY_EXPRESS ]   RAMP2 [ SEEK ]   RAMP2 [ MEM ]
Gene Expression Viewer (FireBrowse)RAMP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10266
GTEX Portal (Tissue expression)RAMP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60895   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60895  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60895
Splice isoforms : SwissVarO60895
PhosPhoSitePlusO60895
Domains : Interpro (EBI)RAMP   
Domain families : Pfam (Sanger)RAMP (PF04901)   
Domain families : Pfam (NCBI)pfam04901   
Conserved Domain (NCBI)RAMP2
DMDM Disease mutations10266
Blocks (Seattle)RAMP2
PDB (SRS)2XVT    3AQE    3AQF    4RWF   
PDB (PDBSum)2XVT    3AQE    3AQF    4RWF   
PDB (IMB)2XVT    3AQE    3AQF    4RWF   
PDB (RSDB)2XVT    3AQE    3AQF    4RWF   
Structural Biology KnowledgeBase2XVT    3AQE    3AQF    4RWF   
SCOP (Structural Classification of Proteins)2XVT    3AQE    3AQF    4RWF   
CATH (Classification of proteins structures)2XVT    3AQE    3AQF    4RWF   
SuperfamilyO60895
Human Protein AtlasENSG00000131477
Peptide AtlasO60895
HPRD05516
IPIIPI00299297   
Protein Interaction databases
DIP (DOE-UCLA)O60895
IntAct (EBI)O60895
FunCoupENSG00000131477
BioGRIDRAMP2
STRING (EMBL)RAMP2
ZODIACRAMP2
Ontologies - Pathways
QuickGOO60895
Ontology : AmiGOangiogenesis  vasculogenesis  response to hypoxia  sprouting angiogenesis  protein binding  cytoplasm  lysosome  plasma membrane  plasma membrane  integral component of plasma membrane  clathrin-coated pit  cAMP biosynthetic process  calcium ion transport  intracellular protein transport  G-protein coupled receptor signaling pathway  heart development  female pregnancy  regulation of blood pressure  regulation of G-protein coupled receptor protein signaling pathway  protein transporter activity  cell surface  positive regulation of gene expression  coreceptor activity  protein transport  positive regulation of cAMP biosynthetic process  receptor internalization  response to estradiol  response to progesterone  cellular response to hormone stimulus  adherens junction assembly  cellular response to vascular endothelial growth factor stimulus  negative regulation of vascular permeability  receptor complex  positive regulation of angiogenesis  bicellular tight junction assembly  basement membrane assembly  protein localization to plasma membrane  vascular smooth muscle cell development  negative regulation of endothelial cell apoptotic process  positive regulation of vasculogenesis  
Ontology : EGO-EBIangiogenesis  vasculogenesis  response to hypoxia  sprouting angiogenesis  protein binding  cytoplasm  lysosome  plasma membrane  plasma membrane  integral component of plasma membrane  clathrin-coated pit  cAMP biosynthetic process  calcium ion transport  intracellular protein transport  G-protein coupled receptor signaling pathway  heart development  female pregnancy  regulation of blood pressure  regulation of G-protein coupled receptor protein signaling pathway  protein transporter activity  cell surface  positive regulation of gene expression  coreceptor activity  protein transport  positive regulation of cAMP biosynthetic process  receptor internalization  response to estradiol  response to progesterone  cellular response to hormone stimulus  adherens junction assembly  cellular response to vascular endothelial growth factor stimulus  negative regulation of vascular permeability  receptor complex  positive regulation of angiogenesis  bicellular tight junction assembly  basement membrane assembly  protein localization to plasma membrane  vascular smooth muscle cell development  negative regulation of endothelial cell apoptotic process  positive regulation of vasculogenesis  
Pathways : KEGGVascular smooth muscle contraction   
NDEx NetworkRAMP2
Atlas of Cancer Signalling NetworkRAMP2
Wikipedia pathwaysRAMP2
Orthology - Evolution
OrthoDB10266
GeneTree (enSembl)ENSG00000131477
Phylogenetic Trees/Animal Genes : TreeFamRAMP2
HOVERGENO60895
HOGENOMO60895
Homologs : HomoloGeneRAMP2
Homology/Alignments : Family Browser (UCSC)RAMP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAMP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAMP2
dbVarRAMP2
ClinVarRAMP2
1000_GenomesRAMP2 
Exome Variant ServerRAMP2
ExAC (Exome Aggregation Consortium)RAMP2 (select the gene name)
Genetic variants : HAPMAP10266
Genomic Variants (DGV)RAMP2 [DGVbeta]
DECIPHERRAMP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAMP2 
Mutations
ICGC Data PortalRAMP2 
TCGA Data PortalRAMP2 
Broad Tumor PortalRAMP2
OASIS PortalRAMP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAMP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAMP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAMP2
DgiDB (Drug Gene Interaction Database)RAMP2
DoCM (Curated mutations)RAMP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAMP2 (select a term)
intoGenRAMP2
Cancer3DRAMP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605154   
Orphanet
MedgenRAMP2
Genetic Testing Registry RAMP2
NextProtO60895 [Medical]
TSGene10266
GENETestsRAMP2
Target ValidationRAMP2
Huge Navigator RAMP2 [HugePedia]
snp3D : Map Gene to Disease10266
BioCentury BCIQRAMP2
ClinGenRAMP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10266
Chemical/Pharm GKB GenePA34203
Clinical trialRAMP2
Miscellaneous
canSAR (ICR)RAMP2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAMP2
EVEXRAMP2
GoPubMedRAMP2
iHOPRAMP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:12:32 CEST 2017

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