RANBP1 (RAN binding protein 1)

2013-11-01 Affiliation

Identity

HGNC

RANBP1

LOCATION

22q11.21

LOCUSID

5902

ALIAS

HTF9A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5902
MIM: 601180
HGNC: 9847
Ensembl: ENSG00000099901

Variants:

dbSNP: 5902
ClinVar: 5902
TCGA: ENSG00000099901
COSMIC: RANBP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000099901	ENST00000331821	P43487
ENSG00000099901	ENST00000331821	A0A140VK94
ENSG00000099901	ENST00000402752	P43487
ENSG00000099901	ENST00000411892	C9JJ34
ENSG00000099901	ENST00000416427	C9JIC6
ENSG00000099901	ENST00000418705	C9JXG8
ENSG00000099901	ENST00000421656	C9JIC6
ENSG00000099901	ENST00000423859	C9JGV6
ENSG00000099901	ENST00000430524	F6WQW2
ENSG00000099901	ENST00000432879	C9JDM3
ENSG00000099901	ENST00000435265	F8WCY3

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Rev-mediated nuclear export of HIV RNA	REACTOME	R-HSA-165054
Host Interactions of HIV factors	REACTOME	R-HSA-162909
Interactions of Rev with host cellular proteins	REACTOME	R-HSA-177243

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17940066	2007	RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.	21
23108393	2013	Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.	20
14585972	2003	Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?	18
20508983	2011	Centrosome-related genes, genetic variation, and risk of breast cancer.	16
19270727	2009	RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.	14
19549784	2009	Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import.	13
20658144	2010	Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.	10
21184585	2011	Association of RANBP1 haplotype with smooth pursuit eye movement abnormality.	5
16428860	2005	Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.	4
21813642	2011	Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression.	4

Citation

Dessen P

RANBP1 (RAN binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53618/ranbp1