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RANGAP1 (Ran GTPase activating protein 1)

Identity

Alias_namesSD
segregation distorter homolog (Drosophila)
Alias_symbol (synonym)Fug1
KIAA1835
Other aliasRANGAP
HGNC (Hugo) RANGAP1
LocusID (NCBI) 5905
Atlas_Id 72484
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 41244777 and ends at 41286017 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GDE1 (16p12.3) / RANGAP1 (22q13.2)RANGAP1 (22q13.2) / CCDC151 (19p13.2)RANGAP1 (22q13.2) / GRID2 (4q22.1)
RANGAP1 (22q13.2) / L3MBTL2 (22q13.2)RANGAP1 (22q13.2) / RANGAP1 (22q13.2)SHC4 (15q21.1) / RANGAP1 (22q13.2)
UNC13B (9p13.3) / RANGAP1 (22q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RANGAP1   9854
Cards
Entrez_Gene (NCBI)RANGAP1  5905  Ran GTPase activating protein 1
AliasesFug1; RANGAP; SD
GeneCards (Weizmann)RANGAP1
Ensembl hg19 (Hinxton)ENSG00000100401 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100401 [Gene_View]  chr22:41244777-41286017 [Contig_View]  RANGAP1 [Vega]
ICGC DataPortalENSG00000100401
TCGA cBioPortalRANGAP1
AceView (NCBI)RANGAP1
Genatlas (Paris)RANGAP1
WikiGenes5905
SOURCE (Princeton)RANGAP1
Genetics Home Reference (NIH)RANGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)RANGAP1  -     chr22:41244777-41286017 -  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RANGAP1  -     22q13.2   [Description]    (hg19-Feb_2009)
EnsemblRANGAP1 - 22q13.2 [CytoView hg19]  RANGAP1 - 22q13.2 [CytoView hg38]
Mapping of homologs : NCBIRANGAP1 [Mapview hg19]  RANGAP1 [Mapview hg38]
OMIM602362   
Gene and transcription
Genbank (Entrez)AB058738 AK302222 AK303524 BC004990 BC014044
RefSeq transcript (Entrez)NM_001278651 NM_001317930 NM_002883
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RANGAP1
Cluster EST : UnigeneHs.183800 [ NCBI ]
CGAP (NCI)Hs.183800
Alternative Splicing GalleryENSG00000100401
Gene ExpressionRANGAP1 [ NCBI-GEO ]   RANGAP1 [ EBI - ARRAY_EXPRESS ]   RANGAP1 [ SEEK ]   RANGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)RANGAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5905
GTEX Portal (Tissue expression)RANGAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46060   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46060  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46060
Splice isoforms : SwissVarP46060
PhosPhoSitePlusP46060
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    Ran_GTPase_activating_1_C    RanGap   
Domain families : Pfam (Sanger)LRR_6 (PF13516)    RanGAP1_C (PF07834)   
Domain families : Pfam (NCBI)pfam13516    pfam07834   
Conserved Domain (NCBI)RANGAP1
DMDM Disease mutations5905
Blocks (Seattle)RANGAP1
PDB (SRS)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
PDB (PDBSum)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
PDB (IMB)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
PDB (RSDB)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
Structural Biology KnowledgeBase1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
SCOP (Structural Classification of Proteins)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
CATH (Classification of proteins structures)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
SuperfamilyP46060
Human Protein AtlasENSG00000100401
Peptide AtlasP46060
HPRD03839
IPIIPI00294879   IPI00879681   IPI00880159   IPI00877824   IPI00879993   
Protein Interaction databases
DIP (DOE-UCLA)P46060
IntAct (EBI)P46060
FunCoupENSG00000100401
BioGRIDRANGAP1
STRING (EMBL)RANGAP1
ZODIACRANGAP1
Ontologies - Pathways
QuickGOP46060
Ontology : AmiGOkinetochore  condensed chromosome kinetochore  spindle pole  GTPase activator activity  protein binding  nuclear envelope  nuclear envelope  nuclear pore  cytoplasm  cytosol  cytosol  sister chromatid cohesion  signal transduction  Ran GTPase binding  aggresome  protein sumoylation  dendrite  ubiquitin protein ligase binding  nuclear membrane  intracellular membrane-bounded organelle  positive regulation of GTPase activity  nuclear pore cytoplasmic filaments  cadherin binding  negative regulation of protein export from nucleus  response to axon injury  mitotic spindle  axon cytoplasm  cellular response to vasopressin  cytoplasmic periphery of the nuclear pore complex  
Ontology : EGO-EBIkinetochore  condensed chromosome kinetochore  spindle pole  GTPase activator activity  protein binding  nuclear envelope  nuclear envelope  nuclear pore  cytoplasm  cytosol  cytosol  sister chromatid cohesion  signal transduction  Ran GTPase binding  aggresome  protein sumoylation  dendrite  ubiquitin protein ligase binding  nuclear membrane  intracellular membrane-bounded organelle  positive regulation of GTPase activity  nuclear pore cytoplasmic filaments  cadherin binding  negative regulation of protein export from nucleus  response to axon injury  mitotic spindle  axon cytoplasm  cellular response to vasopressin  cytoplasmic periphery of the nuclear pore complex  
Pathways : BIOCARTACycling of Ran in nucleocytoplasmic transport [Genes]    Role of Ran in mitotic spindle regulation [Genes]    Mechanism of Protein Import into the Nucleus [Genes]    Sumoylation by RanBP2 Regulates Transcriptional Repression [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkRANGAP1
Atlas of Cancer Signalling NetworkRANGAP1
Wikipedia pathwaysRANGAP1
Orthology - Evolution
OrthoDB5905
GeneTree (enSembl)ENSG00000100401
Phylogenetic Trees/Animal Genes : TreeFamRANGAP1
HOVERGENP46060
HOGENOMP46060
Homologs : HomoloGeneRANGAP1
Homology/Alignments : Family Browser (UCSC)RANGAP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRANGAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RANGAP1
dbVarRANGAP1
ClinVarRANGAP1
1000_GenomesRANGAP1 
Exome Variant ServerRANGAP1
ExAC (Exome Aggregation Consortium)RANGAP1 (select the gene name)
Genetic variants : HAPMAP5905
Genomic Variants (DGV)RANGAP1 [DGVbeta]
DECIPHERRANGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRANGAP1 
Mutations
ICGC Data PortalRANGAP1 
TCGA Data PortalRANGAP1 
Broad Tumor PortalRANGAP1
OASIS PortalRANGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRANGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRANGAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RANGAP1
DgiDB (Drug Gene Interaction Database)RANGAP1
DoCM (Curated mutations)RANGAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RANGAP1 (select a term)
intoGenRANGAP1
Cancer3DRANGAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602362   
Orphanet
MedgenRANGAP1
Genetic Testing Registry RANGAP1
NextProtP46060 [Medical]
TSGene5905
GENETestsRANGAP1
Target ValidationRANGAP1
Huge Navigator RANGAP1 [HugePedia]
snp3D : Map Gene to Disease5905
BioCentury BCIQRANGAP1
ClinGenRANGAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5905
Chemical/Pharm GKB GenePA34216
Clinical trialRANGAP1
Miscellaneous
canSAR (ICR)RANGAP1 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRANGAP1
EVEXRANGAP1
GoPubMedRANGAP1
iHOPRANGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:35:50 CEST 2017

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