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RANGAP1 (Ran GTPase activating protein 1)

Identity

Alias (NCBI)Fug1
RANGAP
SD
HGNC (Hugo) RANGAP1
HGNC Alias symbFug1
KIAA1835
HGNC Previous nameSD
HGNC Previous namesegregation distorter homolog (Drosophila)
LocusID (NCBI) 5905
Atlas_Id 57188
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 41244779 and ends at 41286187 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GDE1 (16p12.3) / RANGAP1 (22q13.2)RANGAP1 (22q13.2) / CCDC151 (19p13.2)RANGAP1 (22q13.2) / GRID2 (4q22.1)
RANGAP1 (22q13.2) / L3MBTL2 (22q13.2)RANGAP1 (22q13.2) / RANGAP1 (22q13.2)SHC4 (15q21.1) / RANGAP1 (22q13.2)
UNC13B (9p13.3) / RANGAP1 (22q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RANGAP1   9854
Cards
Entrez_Gene (NCBI)RANGAP1    Ran GTPase activating protein 1
AliasesFug1; RANGAP; SD
GeneCards (Weizmann)RANGAP1
Ensembl hg19 (Hinxton)ENSG00000100401 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100401 [Gene_View]  ENSG00000100401 [Sequence]  chr22:41244779-41286187 [Contig_View]  RANGAP1 [Vega]
ICGC DataPortalENSG00000100401
TCGA cBioPortalRANGAP1
AceView (NCBI)RANGAP1
Genatlas (Paris)RANGAP1
SOURCE (Princeton)RANGAP1
Genetics Home Reference (NIH)RANGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)RANGAP1  -     chr22:41244779-41286187 -  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RANGAP1  -     22q13.2   [Description]    (hg19-Feb_2009)
GoldenPathRANGAP1 - 22q13.2 [CytoView hg19]  RANGAP1 - 22q13.2 [CytoView hg38]
ImmunoBaseENSG00000100401
Genome Data Viewer NCBIRANGAP1 [Mapview hg19]  
OMIM602362   
Gene and transcription
Genbank (Entrez)AB058738 AK302222 AK303524 BC004990 BC014044
RefSeq transcript (Entrez)NM_001278651 NM_001317930 NM_002883
Consensus coding sequences : CCDS (NCBI)RANGAP1
Gene ExpressionRANGAP1 [ NCBI-GEO ]   RANGAP1 [ EBI - ARRAY_EXPRESS ]   RANGAP1 [ SEEK ]   RANGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)RANGAP1 [ Firebrowse - Broad ]
GenevisibleExpression of RANGAP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5905
GTEX Portal (Tissue expression)RANGAP1
Human Protein AtlasENSG00000100401-RANGAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46060   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46060  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46060
PhosPhoSitePlusP46060
Domains : Interpro (EBI)Leu-rich_rpt    LRR_dom_sf    Ran_GTPase_activating_1_C    RanGAP1_C_sf   
Domain families : Pfam (Sanger)LRR_6 (PF13516)    RanGAP1_C (PF07834)   
Domain families : Pfam (NCBI)pfam13516    pfam07834   
Conserved Domain (NCBI)RANGAP1
PDB (RSDB)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
PDB Europe1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
PDB (PDBSum)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
PDB (IMB)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
Structural Biology KnowledgeBase1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
SCOP (Structural Classification of Proteins)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
CATH (Classification of proteins structures)1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2IO2    2IO3    2IY0    3UIN    3UIO    3UIP    5D2M   
SuperfamilyP46060
AlphaFold pdb e-kbP46060   
Human Protein Atlas [tissue]ENSG00000100401-RANGAP1 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P46060
IntAct (EBI)P46060
BioGRIDRANGAP1
STRING (EMBL)RANGAP1
ZODIACRANGAP1
Ontologies - Pathways
QuickGOP46060
Ontology : AmiGOkinetochore  RNA binding  GTPase activator activity  protein binding  nuclear envelope  nuclear envelope  nuclear pore  nucleoplasm  cytoplasm  cytosol  cytosol  mitotic spindle organization  mitotic nuclear membrane reassembly  signal transduction  aggresome  protein sumoylation  dendrite  small GTPase binding  ubiquitin protein ligase binding  nuclear membrane  intracellular membrane-bounded organelle  nuclear pore cytoplasmic filaments  cadherin binding  negative regulation of protein export from nucleus  perinuclear region of cytoplasm  response to axon injury  mitotic spindle  activation of GTPase activity  axon cytoplasm  cellular response to vasopressin  cytoplasmic periphery of the nuclear pore complex  
Ontology : EGO-EBIkinetochore  RNA binding  GTPase activator activity  protein binding  nuclear envelope  nuclear envelope  nuclear pore  nucleoplasm  cytoplasm  cytosol  cytosol  mitotic spindle organization  mitotic nuclear membrane reassembly  signal transduction  aggresome  protein sumoylation  dendrite  small GTPase binding  ubiquitin protein ligase binding  nuclear membrane  intracellular membrane-bounded organelle  nuclear pore cytoplasmic filaments  cadherin binding  negative regulation of protein export from nucleus  perinuclear region of cytoplasm  response to axon injury  mitotic spindle  activation of GTPase activity  axon cytoplasm  cellular response to vasopressin  cytoplasmic periphery of the nuclear pore complex  
Pathways : BIOCARTACycling of Ran in nucleocytoplasmic transport [Genes]    Role of Ran in mitotic spindle regulation [Genes]    Mechanism of Protein Import into the Nucleus [Genes]    Sumoylation by RanBP2 Regulates Transcriptional Repression [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkRANGAP1
Atlas of Cancer Signalling NetworkRANGAP1
Wikipedia pathwaysRANGAP1
Orthology - Evolution
OrthoDB5905
GeneTree (enSembl)ENSG00000100401
Phylogenetic Trees/Animal Genes : TreeFamRANGAP1
Homologs : HomoloGeneRANGAP1
Homology/Alignments : Family Browser (UCSC)RANGAP1
Gene fusions - Rearrangements
Fusion : QuiverRANGAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRANGAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RANGAP1
dbVarRANGAP1
ClinVarRANGAP1
MonarchRANGAP1
1000_GenomesRANGAP1 
Exome Variant ServerRANGAP1
GNOMAD BrowserENSG00000100401
Varsome BrowserRANGAP1
ACMGRANGAP1 variants
VarityP46060
Genomic Variants (DGV)RANGAP1 [DGVbeta]
DECIPHERRANGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRANGAP1 
Mutations
ICGC Data PortalRANGAP1 
TCGA Data PortalRANGAP1 
Broad Tumor PortalRANGAP1
OASIS PortalRANGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRANGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRANGAP1
Mutations and Diseases : HGMDRANGAP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRANGAP1
DgiDB (Drug Gene Interaction Database)RANGAP1
DoCM (Curated mutations)RANGAP1
CIViC (Clinical Interpretations of Variants in Cancer)RANGAP1
Cancer3DRANGAP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602362   
Orphanet
DisGeNETRANGAP1
MedgenRANGAP1
Genetic Testing Registry RANGAP1
NextProtP46060 [Medical]
GENETestsRANGAP1
Target ValidationRANGAP1
Huge Navigator RANGAP1 [HugePedia]
ClinGenRANGAP1
Clinical trials, drugs, therapy
MyCancerGenomeRANGAP1
Protein Interactions : CTDRANGAP1
Pharm GKB GenePA34216
PharosP46060
Clinical trialRANGAP1
Miscellaneous
canSAR (ICR)RANGAP1
HarmonizomeRANGAP1
DataMed IndexRANGAP1
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRANGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:28:12 CEST 2021

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