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RAP1GAP2 (RAP1 GTPase activating protein 2)

Identity

Alias_namesGARNL4
GTPase activating RANGAP domain-like 4
GTPase activating Rap/RanGAP domain-like 4
Alias_symbol (synonym)KIAA1039
Other aliasRAP1GA3
HGNC (Hugo) RAP1GAP2
LocusID (NCBI) 23108
Atlas_Id 72486
Location 17p13.3  [Link to chromosome band 17p13]
Location_base_pair Starts at 2699732 and ends at 2941035 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ITM2C (2q37.1) / RAP1GAP2 (17p13.3)LTBP3 (11q13.1) / RAP1GAP2 (17p13.3)RAC1 (7p22.1) / RAP1GAP2 (17p13.3)
RAP1GAP2 (17p13.3) / CTTNBP2NL (1p13.2)RAP1GAP2 (17p13.3) / TGOLN2 (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAP1GAP2   29176
Cards
Entrez_Gene (NCBI)RAP1GAP2  23108  RAP1 GTPase activating protein 2
AliasesGARNL4; RAP1GA3
GeneCards (Weizmann)RAP1GAP2
Ensembl hg19 (Hinxton)ENSG00000132359 [Gene_View]  chr17:2699732-2941035 [Contig_View]  RAP1GAP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000132359 [Gene_View]  chr17:2699732-2941035 [Contig_View]  RAP1GAP2 [Vega]
ICGC DataPortalENSG00000132359
TCGA cBioPortalRAP1GAP2
AceView (NCBI)RAP1GAP2
Genatlas (Paris)RAP1GAP2
WikiGenes23108
SOURCE (Princeton)RAP1GAP2
Genetics Home Reference (NIH)RAP1GAP2
Genomic and cartography
GoldenPath hg19 (UCSC)RAP1GAP2  -     chr17:2699732-2941035 +  17p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAP1GAP2  -     17p13.3   [Description]    (hg38-Dec_2013)
EnsemblRAP1GAP2 - 17p13.3 [CytoView hg19]  RAP1GAP2 - 17p13.3 [CytoView hg38]
Mapping of homologs : NCBIRAP1GAP2 [Mapview hg19]  RAP1GAP2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB028962 AJ628446 AJ628447 AK000478 AK124640
RefSeq transcript (Entrez)NM_001100398 NM_015085
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_013030 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)RAP1GAP2
Cluster EST : UnigeneHs.499659 [ NCBI ]
CGAP (NCI)Hs.499659
Alternative Splicing GalleryENSG00000132359
Gene ExpressionRAP1GAP2 [ NCBI-GEO ]   RAP1GAP2 [ EBI - ARRAY_EXPRESS ]   RAP1GAP2 [ SEEK ]   RAP1GAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)RAP1GAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23108
GTEX Portal (Tissue expression)RAP1GAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ684P5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ684P5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ684P5
Splice isoforms : SwissVarQ684P5
PhosPhoSitePlusQ684P5
Domaine pattern : Prosite (Expaxy)RAPGAP (PS50085)   
Domains : Interpro (EBI)Rap_GAP_dom   
Domain families : Pfam (Sanger)Rap_GAP (PF02145)   
Domain families : Pfam (NCBI)pfam02145   
Conserved Domain (NCBI)RAP1GAP2
DMDM Disease mutations23108
Blocks (Seattle)RAP1GAP2
SuperfamilyQ684P5
Human Protein AtlasENSG00000132359
Peptide AtlasQ684P5
HPRD17028
IPIIPI00877122   IPI00855987   IPI00401939   
Protein Interaction databases
DIP (DOE-UCLA)Q684P5
IntAct (EBI)Q684P5
FunCoupENSG00000132359
BioGRIDRAP1GAP2
STRING (EMBL)RAP1GAP2
ZODIACRAP1GAP2
Ontologies - Pathways
QuickGOQ684P5
Ontology : AmiGOGTPase activator activity  cytoplasm  centrosome  cytosol  negative regulation of neuron projection development  nuclear membrane  neuron projection  positive regulation of GTPase activity  perinuclear region of cytoplasm  
Ontology : EGO-EBIGTPase activator activity  cytoplasm  centrosome  cytosol  negative regulation of neuron projection development  nuclear membrane  neuron projection  positive regulation of GTPase activity  perinuclear region of cytoplasm  
NDEx NetworkRAP1GAP2
Atlas of Cancer Signalling NetworkRAP1GAP2
Wikipedia pathwaysRAP1GAP2
Orthology - Evolution
OrthoDB23108
GeneTree (enSembl)ENSG00000132359
Phylogenetic Trees/Animal Genes : TreeFamRAP1GAP2
HOVERGENQ684P5
HOGENOMQ684P5
Homologs : HomoloGeneRAP1GAP2
Homology/Alignments : Family Browser (UCSC)RAP1GAP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAP1GAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAP1GAP2
dbVarRAP1GAP2
ClinVarRAP1GAP2
1000_GenomesRAP1GAP2 
Exome Variant ServerRAP1GAP2
ExAC (Exome Aggregation Consortium)RAP1GAP2 (select the gene name)
Genetic variants : HAPMAP23108
Genomic Variants (DGV)RAP1GAP2 [DGVbeta]
DECIPHER (Syndromes)17:2699732-2941035  ENSG00000132359
CONAN: Copy Number AnalysisRAP1GAP2 
Mutations
ICGC Data PortalRAP1GAP2 
TCGA Data PortalRAP1GAP2 
Broad Tumor PortalRAP1GAP2
OASIS PortalRAP1GAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAP1GAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAP1GAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAP1GAP2
DgiDB (Drug Gene Interaction Database)RAP1GAP2
DoCM (Curated mutations)RAP1GAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAP1GAP2 (select a term)
intoGenRAP1GAP2
Cancer3DRAP1GAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenRAP1GAP2
Genetic Testing Registry RAP1GAP2
NextProtQ684P5 [Medical]
TSGene23108
GENETestsRAP1GAP2
Huge Navigator RAP1GAP2 [HugePedia]
snp3D : Map Gene to Disease23108
BioCentury BCIQRAP1GAP2
ClinGenRAP1GAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23108
Chemical/Pharm GKB GenePA165432528
Clinical trialRAP1GAP2
Miscellaneous
canSAR (ICR)RAP1GAP2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAP1GAP2
EVEXRAP1GAP2
GoPubMedRAP1GAP2
iHOPRAP1GAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:40:32 CET 2017

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