RARRES2 (retinoic acid receptor responder 2)

2012-03-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
HP10433,TIG2

Other Information

Locus ID:

NCBI: 5919
MIM: 601973
HGNC: 9868
Ensembl: ENSG00000106538

Variants:

dbSNP: 5919
ClinVar: 5919
TCGA: ENSG00000106538
COSMIC: RARRES2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106538ENST00000223271Q99969
ENSG00000106538ENST00000223271A0A090N7U9
ENSG00000106538ENST00000466675Q99969
ENSG00000106538ENST00000466675A0A090N7U9
ENSG00000106538ENST00000467793C9J8S2
ENSG00000106538ENST00000482669Q99969
ENSG00000106538ENST00000482669A0A090N7U9

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

References

Pubmed IDYearTitleCitations
176359252007Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism.209
198984812009Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.131
160962702005Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades.94
187943392008Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis.92
208174862010Chemerin: at the crossroads of inflammation and obesity.91
197207982009Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells.86
191146662009Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.78
157282342005Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.76
203752122010Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery.72
195585332010Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes.69

Citation

Dessen P

RARRES2 (retinoic acid receptor responder 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52620/rarres2