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RARS (arginyl-tRNA synthetase)

Identity

Alias_namescytoplasmic
Alias_symbol (synonym)DALRD1
Other aliasArgRS
HLD9
HGNC (Hugo) RARS
LocusID (NCBI) 5917
Atlas_Id 54573
Location 5q34  [Link to chromosome band 5q34]
Location_base_pair Starts at 167913463 and ends at 167946309 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RARS (5q34) / G3BP1 (5q33.1)RARS (5q34) / MAD1L1 (7p22.3)RARS (5q34) / RARS (5q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RARS   9870
Cards
Entrez_Gene (NCBI)RARS  5917  arginyl-tRNA synthetase
AliasesArgRS; DALRD1; HLD9
GeneCards (Weizmann)RARS
Ensembl hg19 (Hinxton)ENSG00000113643 [Gene_View]  chr5:167913463-167946309 [Contig_View]  RARS [Vega]
Ensembl hg38 (Hinxton)ENSG00000113643 [Gene_View]  chr5:167913463-167946309 [Contig_View]  RARS [Vega]
ICGC DataPortalENSG00000113643
TCGA cBioPortalRARS
AceView (NCBI)RARS
Genatlas (Paris)RARS
WikiGenes5917
SOURCE (Princeton)RARS
Genetics Home Reference (NIH)RARS
Genomic and cartography
GoldenPath hg19 (UCSC)RARS  -     chr5:167913463-167946309 +  5q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RARS  -     5q34   [Description]    (hg38-Dec_2013)
EnsemblRARS - 5q34 [CytoView hg19]  RARS - 5q34 [CytoView hg38]
Mapping of homologs : NCBIRARS [Mapview hg19]  RARS [Mapview hg38]
OMIM107820   616140   
Gene and transcription
Genbank (Entrez)AK222797 AK302161 AK314795 AU125370 BC000528
RefSeq transcript (Entrez)NM_002887
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_041809 NT_023133 NW_004929325
Consensus coding sequences : CCDS (NCBI)RARS
Cluster EST : UnigeneHs.654907 [ NCBI ]
CGAP (NCI)Hs.654907
Alternative Splicing GalleryENSG00000113643
Gene ExpressionRARS [ NCBI-GEO ]   RARS [ EBI - ARRAY_EXPRESS ]   RARS [ SEEK ]   RARS [ MEM ]
Gene Expression Viewer (FireBrowse)RARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5917
GTEX Portal (Tissue expression)RARS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54136   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54136  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54136
Splice isoforms : SwissVarP54136
Catalytic activity : Enzyme6.1.1.19 [ Enzyme-Expasy ]   6.1.1.196.1.1.19 [ IntEnz-EBI ]   6.1.1.19 [ BRENDA ]   6.1.1.19 [ KEGG ]   
PhosPhoSitePlusP54136
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    Arg-tRNA-ligase    Arg-tRNA-synth_N    DALR_anticod-bd    Rossmann-like_a/b/a_fold    tRNAsynth_1a_anticodon-bd   
Domain families : Pfam (Sanger)Arg_tRNA_synt_N (PF03485)    DALR_1 (PF05746)    tRNA-synt_1d (PF00750)   
Domain families : Pfam (NCBI)pfam03485    pfam05746    pfam00750   
Domain families : Smart (EMBL)Arg_tRNA_synt_N (SM01016)  DALR_1 (SM00836)  
Conserved Domain (NCBI)RARS
DMDM Disease mutations5917
Blocks (Seattle)RARS
PDB (SRS)4Q2T    4Q2X    4Q2Y    4R3Z   
PDB (PDBSum)4Q2T    4Q2X    4Q2Y    4R3Z   
PDB (IMB)4Q2T    4Q2X    4Q2Y    4R3Z   
PDB (RSDB)4Q2T    4Q2X    4Q2Y    4R3Z   
Structural Biology KnowledgeBase4Q2T    4Q2X    4Q2Y    4R3Z   
SCOP (Structural Classification of Proteins)4Q2T    4Q2X    4Q2Y    4R3Z   
CATH (Classification of proteins structures)4Q2T    4Q2X    4Q2Y    4R3Z   
SuperfamilyP54136
Human Protein AtlasENSG00000113643
Peptide AtlasP54136
HPRD00142
IPIIPI00004860   IPI00759723   IPI01018632   IPI00984107   IPI00974264   IPI00973800   
Protein Interaction databases
DIP (DOE-UCLA)P54136
IntAct (EBI)P54136
FunCoupENSG00000113643
BioGRIDRARS
STRING (EMBL)RARS
ZODIACRARS
Ontologies - Pathways
QuickGOP54136
Ontology : AmiGOtRNA binding  arginine-tRNA ligase activity  arginine-tRNA ligase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  mitochondrion  cytosol  tRNA aminoacylation for protein translation  arginyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  arginine binding  extracellular exosome  
Ontology : EGO-EBItRNA binding  arginine-tRNA ligase activity  arginine-tRNA ligase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  mitochondrion  cytosol  tRNA aminoacylation for protein translation  arginyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  arginine binding  extracellular exosome  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkRARS
Atlas of Cancer Signalling NetworkRARS
Wikipedia pathwaysRARS
Orthology - Evolution
OrthoDB5917
GeneTree (enSembl)ENSG00000113643
Phylogenetic Trees/Animal Genes : TreeFamRARS
HOVERGENP54136
HOGENOMP54136
Homologs : HomoloGeneRARS
Homology/Alignments : Family Browser (UCSC)RARS
Gene fusions - Rearrangements
Fusion : MitelmanRARS/MAD1L1 [5q34/7p22.3]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RARS
dbVarRARS
ClinVarRARS
1000_GenomesRARS 
Exome Variant ServerRARS
ExAC (Exome Aggregation Consortium)RARS (select the gene name)
Genetic variants : HAPMAP5917
Genomic Variants (DGV)RARS [DGVbeta]
DECIPHER (Syndromes)5:167913463-167946309  ENSG00000113643
CONAN: Copy Number AnalysisRARS 
Mutations
ICGC Data PortalRARS 
TCGA Data PortalRARS 
Broad Tumor PortalRARS
OASIS PortalRARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RARS
DgiDB (Drug Gene Interaction Database)RARS
DoCM (Curated mutations)RARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RARS (select a term)
intoGenRARS
Cancer3DRARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107820    616140   
Orphanet23363   
MedgenRARS
Genetic Testing Registry RARS
NextProtP54136 [Medical]
TSGene5917
GENETestsRARS
Huge Navigator RARS [HugePedia]
snp3D : Map Gene to Disease5917
BioCentury BCIQRARS
ClinGenRARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5917
Chemical/Pharm GKB GenePA34231
Clinical trialRARS
Miscellaneous
canSAR (ICR)RARS (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRARS
EVEXRARS
GoPubMedRARS
iHOPRARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:55 CEST 2017

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