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RARS2 (arginyl-tRNA synthetase 2, mitochondrial)

Identity

Alias (NCBI)ArgRS
DALRD2
PCH6
PRO1992
RARSL
HGNC (Hugo) RARS2
HGNC Alias symbMGC14993
MGC23778
PRO1992
dJ382I10.6
DALRD2
HGNC Alias namearginine tRNA ligase 2, mitochondrial (putative)
HGNC Previous nameRARSL
HGNC Previous namearginyl-tRNA synthetase-like
LocusID (NCBI) 57038
Atlas_Id 72491
Location 6q15  [Link to chromosome band 6q15]
Location_base_pair Starts at 87513938 and ends at 87589987 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C7orf31 (7p15.3) / RARS2 (6q15)MAP1B (5q13.2) / RARS2 (6q15)RARS2 (6q15) / HECA (6q24.1)
RARS2 (6q15) / RARS2 (6q15)RARS2 (6q15) / SMAP1 (6q13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RARS2   21406
Cards
Entrez_Gene (NCBI)RARS2    arginyl-tRNA synthetase 2, mitochondrial
AliasesArgRS; DALRD2; PCH6; PRO1992; 
RARSL
GeneCards (Weizmann)RARS2
Ensembl hg19 (Hinxton)ENSG00000146282 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146282 [Gene_View]  ENSG00000146282 [Sequence]  chr6:87513938-87589987 [Contig_View]  RARS2 [Vega]
ICGC DataPortalENSG00000146282
TCGA cBioPortalRARS2
AceView (NCBI)RARS2
Genatlas (Paris)RARS2
SOURCE (Princeton)RARS2
Genetics Home Reference (NIH)RARS2
Genomic and cartography
GoldenPath hg38 (UCSC)RARS2  -     chr6:87513938-87589987 -  6q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RARS2  -     6q15   [Description]    (hg19-Feb_2009)
GoldenPathRARS2 - 6q15 [CytoView hg19]  RARS2 - 6q15 [CytoView hg38]
ImmunoBaseENSG00000146282
Genome Data Viewer NCBIRARS2 [Mapview hg19]  
OMIM611523   611524   
Gene and transcription
Genbank (Entrez)AF118086 AF143874 AI610814 AK023550 AK093934
RefSeq transcript (Entrez)NM_001318785 NM_001350505 NM_001350506 NM_001350507 NM_001350508 NM_001350509 NM_001350510 NM_001350511 NM_020320
Consensus coding sequences : CCDS (NCBI)RARS2
Gene ExpressionRARS2 [ NCBI-GEO ]   RARS2 [ EBI - ARRAY_EXPRESS ]   RARS2 [ SEEK ]   RARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)RARS2 [ Firebrowse - Broad ]
GenevisibleExpression of RARS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57038
GTEX Portal (Tissue expression)RARS2
Human Protein AtlasENSG00000146282-RARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T160   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T160  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T160
Catalytic activity : Enzyme6.1.1.19 [ Enzyme-Expasy ]   6.1.1.196.1.1.19 [ IntEnz-EBI ]   6.1.1.19 [ BRENDA ]   6.1.1.19 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ5T160
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    Arg-tRNA-ligase    Arg-tRNA-synth_N_sf    ArgRS_core    DALR_anticod-bd    Rossmann-like_a/b/a_fold    tRNAsynth_Ia_anticodon-bd   
Domain families : Pfam (Sanger)DALR_1 (PF05746)    tRNA-synt_1d (PF00750)   
Domain families : Pfam (NCBI)pfam05746    pfam00750   
Domain families : Smart (EMBL)DALR_1 (SM00836)  
Conserved Domain (NCBI)RARS2
SuperfamilyQ5T160
AlphaFold pdb e-kbQ5T160   
Human Protein Atlas [tissue]ENSG00000146282-RARS2 [tissue]
HPRD15209
Protein Interaction databases
DIP (DOE-UCLA)Q5T160
IntAct (EBI)Q5T160
BioGRIDRARS2
STRING (EMBL)RARS2
ZODIACRARS2
Ontologies - Pathways
QuickGOQ5T160
Ontology : AmiGORNA binding  arginine-tRNA ligase activity  protein binding  ATP binding  mitochondrion  mitochondrial matrix  tRNA aminoacylation for protein translation  arginyl-tRNA aminoacylation  mitochondrial translation  
Ontology : EGO-EBIRNA binding  arginine-tRNA ligase activity  protein binding  ATP binding  mitochondrion  mitochondrial matrix  tRNA aminoacylation for protein translation  arginyl-tRNA aminoacylation  mitochondrial translation  
NDEx NetworkRARS2
Atlas of Cancer Signalling NetworkRARS2
Wikipedia pathwaysRARS2
Orthology - Evolution
OrthoDB57038
GeneTree (enSembl)ENSG00000146282
Phylogenetic Trees/Animal Genes : TreeFamRARS2
Homologs : HomoloGeneRARS2
Homology/Alignments : Family Browser (UCSC)RARS2
Gene fusions - Rearrangements
Fusion : QuiverRARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RARS2
dbVarRARS2
ClinVarRARS2
MonarchRARS2
1000_GenomesRARS2 
Exome Variant ServerRARS2
GNOMAD BrowserENSG00000146282
Varsome BrowserRARS2
ACMGRARS2 variants
VarityQ5T160
Genomic Variants (DGV)RARS2 [DGVbeta]
DECIPHERRARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRARS2 
Mutations
ICGC Data PortalRARS2 
TCGA Data PortalRARS2 
Broad Tumor PortalRARS2
OASIS PortalRARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRARS2
Mutations and Diseases : HGMDRARS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRARS2
DgiDB (Drug Gene Interaction Database)RARS2
DoCM (Curated mutations)RARS2
CIViC (Clinical Interpretations of Variants in Cancer)RARS2
Cancer3DRARS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611523    611524   
Orphanet17610    3132   
DisGeNETRARS2
MedgenRARS2
Genetic Testing Registry RARS2
NextProtQ5T160 [Medical]
GENETestsRARS2
Target ValidationRARS2
Huge Navigator RARS2 [HugePedia]
ClinGenRARS2
Clinical trials, drugs, therapy
MyCancerGenomeRARS2
Protein Interactions : CTDRARS2
Pharm GKB GenePA162400662
PharosQ5T160
Clinical trialRARS2
Miscellaneous
canSAR (ICR)RARS2
HarmonizomeRARS2
DataMed IndexRARS2
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:17:56 CEST 2021

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