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RASA2 (RAS p21 protein activator 2)

Identity

Alias_symbol (synonym)GAP1M
Other alias
HGNC (Hugo) RASA2
LocusID (NCBI) 5922
Atlas_Id 42052
Location 3q23  [Link to chromosome band 3q23]
Location_base_pair Starts at 141205889 and ends at 141334205 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RASA2 (3q23) / HSP90AB1 (6p21.1)RASA2 (3q23) / NELFB (9q34.3)RASA2 (3q23) / NICN1 (3p21.31)
RASA2 (3q23) / PXYLP1 (3q23)RASA2 (3q23) / RASA2 (3q23)RASA2 (3q23) / SUCNR1 (3q25.1)
RASA2 (3q23) / ZBTB38 (3q23)RASA2 3q23 ACPL2RASA2 3q23 COBRA1
RASA2 3q23 / SUCNR1 3q25.1RASA2 3q23 / ZBTB38 3q23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)RASA2   9872
Cards
Entrez_Gene (NCBI)RASA2  5922  RAS p21 protein activator 2
AliasesGAP1M
GeneCards (Weizmann)RASA2
Ensembl hg19 (Hinxton)ENSG00000155903 [Gene_View]  chr3:141205889-141334205 [Contig_View]  RASA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000155903 [Gene_View]  chr3:141205889-141334205 [Contig_View]  RASA2 [Vega]
ICGC DataPortalENSG00000155903
TCGA cBioPortalRASA2
AceView (NCBI)RASA2
Genatlas (Paris)RASA2
WikiGenes5922
SOURCE (Princeton)RASA2
Genetics Home Reference (NIH)RASA2
Genomic and cartography
GoldenPath hg19 (UCSC)RASA2  -     chr3:141205889-141334205 +  3q23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RASA2  -     3q23   [Description]    (hg38-Dec_2013)
EnsemblRASA2 - 3q23 [CytoView hg19]  RASA2 - 3q23 [CytoView hg38]
Mapping of homologs : NCBIRASA2 [Mapview hg19]  RASA2 [Mapview hg38]
OMIM601589   
Gene and transcription
Genbank (Entrez)AA214345 AB209161 AF115573 AK025305 AK292016
RefSeq transcript (Entrez)NM_001303245 NM_001303246 NM_006506
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_042187 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)RASA2
Cluster EST : UnigeneHs.655941 [ NCBI ]
CGAP (NCI)Hs.655941
Alternative Splicing GalleryENSG00000155903
Gene ExpressionRASA2 [ NCBI-GEO ]   RASA2 [ EBI - ARRAY_EXPRESS ]   RASA2 [ SEEK ]   RASA2 [ MEM ]
Gene Expression Viewer (FireBrowse)RASA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5922
GTEX Portal (Tissue expression)RASA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15283   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15283  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15283
Splice isoforms : SwissVarQ15283
PhosPhoSitePlusQ15283
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)    ZF_BTK (PS51113)   
Domains : Interpro (EBI)C2_dom    PH_dom-like    PH_domain    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot    Znf_Btk_motif   
Domain families : Pfam (Sanger)BTK (PF00779)    C2 (PF00168)    PH (PF00169)    RasGAP (PF00616)   
Domain families : Pfam (NCBI)pfam00779    pfam00168    pfam00169    pfam00616   
Domain families : Smart (EMBL)BTK (SM00107)  C2 (SM00239)  PH (SM00233)  RasGAP (SM00323)  
Conserved Domain (NCBI)RASA2
DMDM Disease mutations5922
Blocks (Seattle)RASA2
SuperfamilyQ15283
Human Protein AtlasENSG00000155903
Peptide AtlasQ15283
IPIIPI00015811   IPI00910244   IPI00794695   IPI00964015   
Protein Interaction databases
DIP (DOE-UCLA)Q15283
IntAct (EBI)Q15283
FunCoupENSG00000155903
BioGRIDRASA2
STRING (EMBL)RASA2
ZODIACRASA2
Ontologies - Pathways
QuickGOQ15283
Ontology : AmiGOMAPK cascade  GTPase activator activity  cytoplasm  cytosol  signal transduction  intrinsic component of the cytoplasmic side of the plasma membrane  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  metal ion binding  perinuclear region of cytoplasm  
Ontology : EGO-EBIMAPK cascade  GTPase activator activity  cytoplasm  cytosol  signal transduction  intrinsic component of the cytoplasmic side of the plasma membrane  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  metal ion binding  perinuclear region of cytoplasm  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Viral carcinogenesis   
NDEx NetworkRASA2
Atlas of Cancer Signalling NetworkRASA2
Wikipedia pathwaysRASA2
Orthology - Evolution
OrthoDB5922
GeneTree (enSembl)ENSG00000155903
Phylogenetic Trees/Animal Genes : TreeFamRASA2
HOVERGENQ15283
HOGENOMQ15283
Homologs : HomoloGeneRASA2
Homology/Alignments : Family Browser (UCSC)RASA2
Gene fusions - Rearrangements
Fusion : MitelmanRASA2/NELFB [3q23/9q34.3]  
Fusion : MitelmanRASA2/NICN1 [3q23/3p21.31]  [t(3;3)(p21;q23)]  
Fusion : MitelmanRASA2/SUCNR1 [3q23/3q25.1]  [t(3;3)(q23;q25)]  
Fusion: TCGARASA2 3q23 ACPL2 LUSC
Fusion: TCGARASA2 3q23 COBRA1 BRCA
Fusion: TCGARASA2 3q23 SUCNR1 3q25.1 OV
Fusion: TCGARASA2 3q23 ZBTB38 3q23 BLCA LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASA2
dbVarRASA2
ClinVarRASA2
1000_GenomesRASA2 
Exome Variant ServerRASA2
ExAC (Exome Aggregation Consortium)RASA2 (select the gene name)
Genetic variants : HAPMAP5922
Genomic Variants (DGV)RASA2 [DGVbeta]
DECIPHER (Syndromes)3:141205889-141334205  ENSG00000155903
CONAN: Copy Number AnalysisRASA2 
Mutations
ICGC Data PortalRASA2 
TCGA Data PortalRASA2 
Broad Tumor PortalRASA2
OASIS PortalRASA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASA2
intOGen PortalRASA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASA2
DgiDB (Drug Gene Interaction Database)RASA2
DoCM (Curated mutations)RASA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASA2 (select a term)
intoGenRASA2
Cancer3DRASA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601589   
Orphanet206   
MedgenRASA2
Genetic Testing Registry RASA2
NextProtQ15283 [Medical]
TSGene5922
GENETestsRASA2
Huge Navigator RASA2 [HugePedia]
snp3D : Map Gene to Disease5922
BioCentury BCIQRASA2
ClinGenRASA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5922
Chemical/Pharm GKB GenePA34233
Clinical trialRASA2
Miscellaneous
canSAR (ICR)RASA2 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASA2
EVEXRASA2
GoPubMedRASA2
iHOPRASA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:24:25 CET 2017

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