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RASA3 (RAS p21 protein activator 3)

Identity

Alias_symbol (synonym)GAP1IP4BP
GAPIII
Other alias
HGNC (Hugo) RASA3
LocusID (NCBI) 22821
Atlas_Id 42053
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 113977783 and ends at 114132623 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNTN4 (3p26.3) / RASA3 (13q34)CYTH1 (17q25.3) / RASA3 (13q34)RASA3 (13q34) / GFAP (17q21.31)
TRIM2 (4q31.3) / RASA3 (13q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RASA3   20331
Cards
Entrez_Gene (NCBI)RASA3  22821  RAS p21 protein activator 3
AliasesGAP1IP4BP; GAPIII
GeneCards (Weizmann)RASA3
Ensembl hg19 (Hinxton)ENSG00000185989 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185989 [Gene_View]  chr13:113977783-114132623 [Contig_View]  RASA3 [Vega]
ICGC DataPortalENSG00000185989
TCGA cBioPortalRASA3
AceView (NCBI)RASA3
Genatlas (Paris)RASA3
WikiGenes22821
SOURCE (Princeton)RASA3
Genetics Home Reference (NIH)RASA3
Genomic and cartography
GoldenPath hg38 (UCSC)RASA3  -     chr13:113977783-114132623 -  13q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASA3  -     13q34   [Description]    (hg19-Feb_2009)
EnsemblRASA3 - 13q34 [CytoView hg19]  RASA3 - 13q34 [CytoView hg38]
Mapping of homologs : NCBIRASA3 [Mapview hg19]  RASA3 [Mapview hg38]
OMIM605182   
Gene and transcription
Genbank (Entrez)AK128094 AK289746 AK294913 AK295861 AK308880
RefSeq transcript (Entrez)NM_001320821 NM_001320822 NM_007368
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RASA3
Cluster EST : UnigeneHs.593075 [ NCBI ]
CGAP (NCI)Hs.593075
Alternative Splicing GalleryENSG00000185989
Gene ExpressionRASA3 [ NCBI-GEO ]   RASA3 [ EBI - ARRAY_EXPRESS ]   RASA3 [ SEEK ]   RASA3 [ MEM ]
Gene Expression Viewer (FireBrowse)RASA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22821
GTEX Portal (Tissue expression)RASA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14644   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14644  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14644
Splice isoforms : SwissVarQ14644
PhosPhoSitePlusQ14644
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)    ZF_BTK (PS51113)   
Domains : Interpro (EBI)C2_dom    PH_dom-like    PH_domain    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot    Znf_Btk_motif   
Domain families : Pfam (Sanger)BTK (PF00779)    C2 (PF00168)    PH (PF00169)    RasGAP (PF00616)   
Domain families : Pfam (NCBI)pfam00779    pfam00168    pfam00169    pfam00616   
Domain families : Smart (EMBL)BTK (SM00107)  C2 (SM00239)  PH (SM00233)  RasGAP (SM00323)  
Conserved Domain (NCBI)RASA3
DMDM Disease mutations22821
Blocks (Seattle)RASA3
SuperfamilyQ14644
Human Protein AtlasENSG00000185989
Peptide AtlasQ14644
HPRD05537
IPIIPI01018718   IPI00921898   IPI00784114   
Protein Interaction databases
DIP (DOE-UCLA)Q14644
IntAct (EBI)Q14644
FunCoupENSG00000185989
BioGRIDRASA3
STRING (EMBL)RASA3
ZODIACRASA3
Ontologies - Pathways
QuickGOQ14644
Ontology : AmiGOMAPK cascade  GTPase activator activity  cytoplasm  cytosol  signal transduction  calcium-release channel activity  intrinsic component of the cytoplasmic side of the plasma membrane  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  metal ion binding  release of sequestered calcium ion into cytosol  
Ontology : EGO-EBIMAPK cascade  GTPase activator activity  cytoplasm  cytosol  signal transduction  calcium-release channel activity  intrinsic component of the cytoplasmic side of the plasma membrane  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  metal ion binding  release of sequestered calcium ion into cytosol  
Pathways : KEGGRas signaling pathway   
NDEx NetworkRASA3
Atlas of Cancer Signalling NetworkRASA3
Wikipedia pathwaysRASA3
Orthology - Evolution
OrthoDB22821
GeneTree (enSembl)ENSG00000185989
Phylogenetic Trees/Animal Genes : TreeFamRASA3
HOVERGENQ14644
HOGENOMQ14644
Homologs : HomoloGeneRASA3
Homology/Alignments : Family Browser (UCSC)RASA3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASA3
dbVarRASA3
ClinVarRASA3
1000_GenomesRASA3 
Exome Variant ServerRASA3
ExAC (Exome Aggregation Consortium)RASA3 (select the gene name)
Genetic variants : HAPMAP22821
Genomic Variants (DGV)RASA3 [DGVbeta]
DECIPHERRASA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASA3 
Mutations
ICGC Data PortalRASA3 
TCGA Data PortalRASA3 
Broad Tumor PortalRASA3
OASIS PortalRASA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASA3
DgiDB (Drug Gene Interaction Database)RASA3
DoCM (Curated mutations)RASA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASA3 (select a term)
intoGenRASA3
Cancer3DRASA3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605182   
Orphanet
MedgenRASA3
Genetic Testing Registry RASA3
NextProtQ14644 [Medical]
TSGene22821
GENETestsRASA3
Target ValidationRASA3
Huge Navigator RASA3 [HugePedia]
snp3D : Map Gene to Disease22821
BioCentury BCIQRASA3
ClinGenRASA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22821
Chemical/Pharm GKB GenePA134905447
Clinical trialRASA3
Miscellaneous
canSAR (ICR)RASA3 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASA3
EVEXRASA3
GoPubMedRASA3
iHOPRASA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:28:07 CEST 2017

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