Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RASA4 (RAS p21 protein activator 4)

Identity

Alias_symbol (synonym)KIAA0538
CAPRI
GAPL
Other alias
HGNC (Hugo) RASA4
LocusID (NCBI) 10156
Atlas_Id 72492
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 102579646 and ends at 102616758 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		HERPUD2 (7p14.2) / RASA4 (7q22.1)PRRC2A (6p21.33) / RASA4 (7q22.1)RASA4 (7q22.1) / SNAP25 (20p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RASA4   23181
Cards
Entrez_Gene (NCBI)RASA4  10156  RAS p21 protein activator 4
AliasesCAPRI; GAPL
GeneCards (Weizmann)RASA4
Ensembl hg19 (Hinxton)ENSG00000105808 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105808 [Gene_View]  chr7:102579646-102616758 [Contig_View]  RASA4 [Vega]
ICGC DataPortalENSG00000105808
TCGA cBioPortalRASA4
AceView (NCBI)RASA4
Genatlas (Paris)RASA4
WikiGenes10156
SOURCE (Princeton)RASA4
Genetics Home Reference (NIH)RASA4
Genomic and cartography
GoldenPath hg38 (UCSC)RASA4  -     chr7:102579646-102616758 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASA4  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblRASA4 - 7q22.1 [CytoView hg19]  RASA4 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIRASA4 [Mapview hg19]  RASA4 [Mapview hg38]
OMIM607943   
Gene and transcription
Genbank (Entrez)AB011110 AK026441 AK093486 AK302370 AK308653
RefSeq transcript (Entrez)NM_001079877 NM_006989
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RASA4
Cluster EST : UnigeneHs.656696 [ NCBI ]
CGAP (NCI)Hs.656696
Alternative Splicing GalleryENSG00000105808
Gene ExpressionRASA4 [ NCBI-GEO ]   RASA4 [ EBI - ARRAY_EXPRESS ]   RASA4 [ SEEK ]   RASA4 [ MEM ]
Gene Expression Viewer (FireBrowse)RASA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10156
GTEX Portal (Tissue expression)RASA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43374   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43374  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43374
Splice isoforms : SwissVarO43374
PhosPhoSitePlusO43374
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)    ZF_BTK (PS51113)   
Domains : Interpro (EBI)C2_dom    PH_dom-like    PH_domain    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot    Znf_Btk_motif   
Domain families : Pfam (Sanger)BTK (PF00779)    C2 (PF00168)    PH (PF00169)    RasGAP (PF00616)   
Domain families : Pfam (NCBI)pfam00779    pfam00168    pfam00169    pfam00616   
Domain families : Smart (EMBL)BTK (SM00107)  C2 (SM00239)  PH (SM00233)  RasGAP (SM00323)  
Conserved Domain (NCBI)RASA4
DMDM Disease mutations10156
Blocks (Seattle)RASA4
SuperfamilyO43374
Human Protein AtlasENSG00000105808
Peptide AtlasO43374
HPRD12135
IPIIPI00946780   
Protein Interaction databases
DIP (DOE-UCLA)O43374
IntAct (EBI)O43374
FunCoupENSG00000105808
BioGRIDRASA4
STRING (EMBL)RASA4
ZODIACRASA4
Ontologies - Pathways
QuickGOO43374
Ontology : AmiGOMAPK cascade  GTPase activator activity  cytosol  cytosol  plasma membrane  intrinsic component of the cytoplasmic side of the plasma membrane  negative regulation of GTPase activity  negative regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  metal ion binding  cellular response to calcium ion  
Ontology : EGO-EBIMAPK cascade  GTPase activator activity  cytosol  cytosol  plasma membrane  intrinsic component of the cytoplasmic side of the plasma membrane  negative regulation of GTPase activity  negative regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  metal ion binding  cellular response to calcium ion  
Pathways : KEGGRas signaling pathway   
NDEx NetworkRASA4
Atlas of Cancer Signalling NetworkRASA4
Wikipedia pathwaysRASA4
Orthology - Evolution
OrthoDB10156
GeneTree (enSembl)ENSG00000105808
Phylogenetic Trees/Animal Genes : TreeFamRASA4
HOVERGENO43374
HOGENOMO43374
Homologs : HomoloGeneRASA4
Homology/Alignments : Family Browser (UCSC)RASA4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASA4
dbVarRASA4
ClinVarRASA4
1000_GenomesRASA4 
Exome Variant ServerRASA4
ExAC (Exome Aggregation Consortium)RASA4 (select the gene name)
Genetic variants : HAPMAP10156
Genomic Variants (DGV)RASA4 [DGVbeta]
DECIPHERRASA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASA4 
Mutations
ICGC Data PortalRASA4 
TCGA Data PortalRASA4 
Broad Tumor PortalRASA4
OASIS PortalRASA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASA4
DgiDB (Drug Gene Interaction Database)RASA4
DoCM (Curated mutations)RASA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASA4 (select a term)
intoGenRASA4
Cancer3DRASA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607943   
Orphanet
MedgenRASA4
Genetic Testing Registry RASA4
NextProtO43374 [Medical]
TSGene10156
GENETestsRASA4
Target ValidationRASA4
Huge Navigator RASA4 [HugePedia]
snp3D : Map Gene to Disease10156
BioCentury BCIQRASA4
ClinGenRASA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10156
Chemical/Pharm GKB GenePA134889495
Clinical trialRASA4
Miscellaneous
canSAR (ICR)RASA4 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASA4
EVEXRASA4
GoPubMedRASA4
iHOPRASA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:38:12 CEST 2017
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