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RASAL1 (RAS protein activator like 1)

Identity

Alias_namesRAS protein activator like 1 (GAP1 like)
Alias_symbol (synonym)RASAL
Other alias
HGNC (Hugo) RASAL1
LocusID (NCBI) 8437
Atlas_Id 42054
Location 12q24.13  [Link to chromosome band 12q24]
Location_base_pair Starts at 113098819 and ends at 113136239 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RASAL1 (12q24.13) / ARL4C (2q37.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RASAL1   9873
Cards
Entrez_Gene (NCBI)RASAL1  8437  RAS protein activator like 1
AliasesRASAL
GeneCards (Weizmann)RASAL1
Ensembl hg19 (Hinxton)ENSG00000111344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111344 [Gene_View]  chr12:113098819-113136239 [Contig_View]  RASAL1 [Vega]
ICGC DataPortalENSG00000111344
TCGA cBioPortalRASAL1
AceView (NCBI)RASAL1
Genatlas (Paris)RASAL1
WikiGenes8437
SOURCE (Princeton)RASAL1
Genetics Home Reference (NIH)RASAL1
Genomic and cartography
GoldenPath hg38 (UCSC)RASAL1  -     chr12:113098819-113136239 -  12q24.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASAL1  -     12q24.13   [Description]    (hg19-Feb_2009)
EnsemblRASAL1 - 12q24.13 [CytoView hg19]  RASAL1 - 12q24.13 [CytoView hg38]
Mapping of homologs : NCBIRASAL1 [Mapview hg19]  RASAL1 [Mapview hg38]
OMIM604118   
Gene and transcription
Genbank (Entrez)AB208935 AF086713 AK294350 AK309562 AL136672
RefSeq transcript (Entrez)NM_001193520 NM_001193521 NM_001301202 NM_004658
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RASAL1
Cluster EST : UnigeneHs.528693 [ NCBI ]
CGAP (NCI)Hs.528693
Alternative Splicing GalleryENSG00000111344
Gene ExpressionRASAL1 [ NCBI-GEO ]   RASAL1 [ EBI - ARRAY_EXPRESS ]   RASAL1 [ SEEK ]   RASAL1 [ MEM ]
Gene Expression Viewer (FireBrowse)RASAL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8437
GTEX Portal (Tissue expression)RASAL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95294   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95294  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95294
Splice isoforms : SwissVarO95294
PhosPhoSitePlusO95294
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)    ZF_BTK (PS51113)   
Domains : Interpro (EBI)C2_dom    PH_dom-like    PH_domain    RASAL1    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot    Znf_Btk_motif   
Domain families : Pfam (Sanger)BTK (PF00779)    C2 (PF00168)    PH (PF00169)    RasGAP (PF00616)   
Domain families : Pfam (NCBI)pfam00779    pfam00168    pfam00169    pfam00616   
Domain families : Smart (EMBL)BTK (SM00107)  C2 (SM00239)  PH (SM00233)  RasGAP (SM00323)  
Conserved Domain (NCBI)RASAL1
DMDM Disease mutations8437
Blocks (Seattle)RASAL1
SuperfamilyO95294
Human Protein AtlasENSG00000111344
Peptide AtlasO95294
HPRD04986
IPIIPI00291306   IPI00216356   IPI00796392   IPI00979198   
Protein Interaction databases
DIP (DOE-UCLA)O95294
IntAct (EBI)O95294
FunCoupENSG00000111344
BioGRIDRASAL1
STRING (EMBL)RASAL1
ZODIACRASAL1
Ontologies - Pathways
QuickGOO95294
Ontology : AmiGOMAPK cascade  GTPase activator activity  phospholipid binding  cytosol  cytosol  plasma membrane  signal transduction  intrinsic component of the cytoplasmic side of the plasma membrane  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  metal ion binding  positive regulation of dendrite extension  
Ontology : EGO-EBIMAPK cascade  GTPase activator activity  phospholipid binding  cytosol  cytosol  plasma membrane  signal transduction  intrinsic component of the cytoplasmic side of the plasma membrane  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  metal ion binding  positive regulation of dendrite extension  
Pathways : KEGGRas signaling pathway   
NDEx NetworkRASAL1
Atlas of Cancer Signalling NetworkRASAL1
Wikipedia pathwaysRASAL1
Orthology - Evolution
OrthoDB8437
GeneTree (enSembl)ENSG00000111344
Phylogenetic Trees/Animal Genes : TreeFamRASAL1
HOVERGENO95294
HOGENOMO95294
Homologs : HomoloGeneRASAL1
Homology/Alignments : Family Browser (UCSC)RASAL1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASAL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASAL1
dbVarRASAL1
ClinVarRASAL1
1000_GenomesRASAL1 
Exome Variant ServerRASAL1
ExAC (Exome Aggregation Consortium)RASAL1 (select the gene name)
Genetic variants : HAPMAP8437
Genomic Variants (DGV)RASAL1 [DGVbeta]
DECIPHERRASAL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASAL1 
Mutations
ICGC Data PortalRASAL1 
TCGA Data PortalRASAL1 
Broad Tumor PortalRASAL1
OASIS PortalRASAL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASAL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASAL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASAL1
DgiDB (Drug Gene Interaction Database)RASAL1
DoCM (Curated mutations)RASAL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASAL1 (select a term)
intoGenRASAL1
Cancer3DRASAL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604118   
Orphanet
MedgenRASAL1
Genetic Testing Registry RASAL1
NextProtO95294 [Medical]
TSGene8437
GENETestsRASAL1
Target ValidationRASAL1
Huge Navigator RASAL1 [HugePedia]
snp3D : Map Gene to Disease8437
BioCentury BCIQRASAL1
ClinGenRASAL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8437
Chemical/Pharm GKB GenePA34234
Clinical trialRASAL1
Miscellaneous
canSAR (ICR)RASAL1 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASAL1
EVEXRASAL1
GoPubMedRASAL1
iHOPRASAL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:52:36 CEST 2017

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