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RASAL2 (RAS protein activator like 2)

Identity

Alias_symbol (synonym)nGAP
Other aliasNGAP
HGNC (Hugo) RASAL2
LocusID (NCBI) 9462
Atlas_Id 53641
Location 1q25.2  [Link to chromosome band 1q25]
Location_base_pair Starts at 178310606 and ends at 178448648 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BCL9 (1q21.2) / RASAL2 (1q25.2)FCRL1 (1q23.1) / RASAL2 (1q25.2)GPD2 (2q24.1) / RASAL2 (1q25.2)
NPR2 (9p13.3) / RASAL2 (1q25.2)RASAL2 (1q25.2) / GALNTL6 (4q34.1)RASAL2 (1q25.2) / PPM1G (2p23.3)
RASAL2 (1q25.2) / RASAL2 (1q25.2)RASAL2 (1q25.2) / SARDH (9q34.2)RASAL2 (1q25.2) / ZNF695 (1q44)
WDR60 (7q36.3) / RASAL2 (1q25.2)RASAL2 1q25.2 / GALNTL6 4q34.1RASAL2 1q25.2 / ZNF695 1q44

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RASAL2   9874
Cards
Entrez_Gene (NCBI)RASAL2  9462  RAS protein activator like 2
AliasesNGAP
GeneCards (Weizmann)RASAL2
Ensembl hg19 (Hinxton)ENSG00000075391 [Gene_View]  chr1:178310606-178448648 [Contig_View]  RASAL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000075391 [Gene_View]  chr1:178310606-178448648 [Contig_View]  RASAL2 [Vega]
ICGC DataPortalENSG00000075391
TCGA cBioPortalRASAL2
AceView (NCBI)RASAL2
Genatlas (Paris)RASAL2
WikiGenes9462
SOURCE (Princeton)RASAL2
Genetics Home Reference (NIH)RASAL2
Genomic and cartography
GoldenPath hg19 (UCSC)RASAL2  -     chr1:178310606-178448648 +  1q25.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RASAL2  -     1q25.2   [Description]    (hg38-Dec_2013)
EnsemblRASAL2 - 1q25.2 [CytoView hg19]  RASAL2 - 1q25.2 [CytoView hg38]
Mapping of homologs : NCBIRASAL2 [Mapview hg19]  RASAL2 [Mapview hg38]
OMIM606136   
Gene and transcription
Genbank (Entrez)AA127237 AB007970 AB209789 AF047711 AK000981
RefSeq transcript (Entrez)NM_004841 NM_170692
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)RASAL2
Cluster EST : UnigeneHs.496139 [ NCBI ]
CGAP (NCI)Hs.496139
Alternative Splicing GalleryENSG00000075391
Gene ExpressionRASAL2 [ NCBI-GEO ]   RASAL2 [ EBI - ARRAY_EXPRESS ]   RASAL2 [ SEEK ]   RASAL2 [ MEM ]
Gene Expression Viewer (FireBrowse)RASAL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9462
GTEX Portal (Tissue expression)RASAL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJF2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJF2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJF2
Splice isoforms : SwissVarQ9UJF2
PhosPhoSitePlusQ9UJF2
Domaine pattern : Prosite (Expaxy)RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)   
Domains : Interpro (EBI)C2_dom    DUF3498    PH_dom-like    PH_domain    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot   
Domain families : Pfam (Sanger)C2 (PF00168)    DUF3498 (PF12004)    RasGAP (PF00616)   
Domain families : Pfam (NCBI)pfam00168    pfam12004    pfam00616   
Domain families : Smart (EMBL)C2 (SM00239)  PH (SM00233)  RasGAP (SM00323)  
Conserved Domain (NCBI)RASAL2
DMDM Disease mutations9462
Blocks (Seattle)RASAL2
SuperfamilyQ9UJF2
Human Protein AtlasENSG00000075391
Peptide AtlasQ9UJF2
HPRD05845
IPIIPI00006854   IPI00645245   IPI00946817   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJF2
IntAct (EBI)Q9UJF2
FunCoupENSG00000075391
BioGRIDRASAL2
STRING (EMBL)RASAL2
ZODIACRASAL2
Ontologies - Pathways
QuickGOQ9UJF2
Ontology : AmiGOMAPK cascade  GTPase activator activity  protein binding  cytoplasm  cytosol  signal transduction  intrinsic component of the cytoplasmic side of the plasma membrane  positive regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  
Ontology : EGO-EBIMAPK cascade  GTPase activator activity  protein binding  cytoplasm  cytosol  signal transduction  intrinsic component of the cytoplasmic side of the plasma membrane  positive regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of Ras protein signal transduction  
Pathways : KEGGRas signaling pathway   
NDEx NetworkRASAL2
Atlas of Cancer Signalling NetworkRASAL2
Wikipedia pathwaysRASAL2
Orthology - Evolution
OrthoDB9462
GeneTree (enSembl)ENSG00000075391
Phylogenetic Trees/Animal Genes : TreeFamRASAL2
HOVERGENQ9UJF2
HOGENOMQ9UJF2
Homologs : HomoloGeneRASAL2
Homology/Alignments : Family Browser (UCSC)RASAL2
Gene fusions - Rearrangements
Fusion : MitelmanBCL9/RASAL2 [1q21.2/1q25.2]  [del(1)(q21q25)]  
Fusion : MitelmanFCRL1/RASAL2 [1q23.1/1q25.2]  [t(1;1)(q23;q25)]  
Fusion : MitelmanRASAL2/GALNTL6 [1q25.2/4q34.1]  [t(1;4)(q25;q34)]  
Fusion : MitelmanRASAL2/ZNF695 [1q25.2/1q44]  [t(1;1)(q25;q44)]  
Fusion: TCGARASAL2 1q25.2 GALNTL6 4q34.1 LUAD
Fusion: TCGARASAL2 1q25.2 ZNF695 1q44 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASAL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASAL2
dbVarRASAL2
ClinVarRASAL2
1000_GenomesRASAL2 
Exome Variant ServerRASAL2
ExAC (Exome Aggregation Consortium)RASAL2 (select the gene name)
Genetic variants : HAPMAP9462
Genomic Variants (DGV)RASAL2 [DGVbeta]
DECIPHER (Syndromes)1:178310606-178448648  ENSG00000075391
CONAN: Copy Number AnalysisRASAL2 
Mutations
ICGC Data PortalRASAL2 
TCGA Data PortalRASAL2 
Broad Tumor PortalRASAL2
OASIS PortalRASAL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASAL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASAL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASAL2
DgiDB (Drug Gene Interaction Database)RASAL2
DoCM (Curated mutations)RASAL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASAL2 (select a term)
intoGenRASAL2
Cancer3DRASAL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606136   
Orphanet
MedgenRASAL2
Genetic Testing Registry RASAL2
NextProtQ9UJF2 [Medical]
TSGene9462
GENETestsRASAL2
Huge Navigator RASAL2 [HugePedia]
snp3D : Map Gene to Disease9462
BioCentury BCIQRASAL2
ClinGenRASAL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9462
Chemical/Pharm GKB GenePA34235
Clinical trialRASAL2
Miscellaneous
canSAR (ICR)RASAL2 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASAL2
EVEXRASAL2
GoPubMedRASAL2
iHOPRASAL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:26 CET 2017

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