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RASGEF1B (RasGEF domain family member 1B)

Identity

Alias_symbol (synonym)GPIG4
FLJ31695
Other alias
HGNC (Hugo) RASGEF1B
LocusID (NCBI) 153020
Atlas_Id 43451
Location 4q21.21  [Link to chromosome band 4q21]
Location_base_pair Starts at 81426393 and ends at 81471928 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP8A1 (4p13) / RASGEF1B (4q21.21)MNAT1 (14q23.1) / RASGEF1B (4q21.21)RASGEF1B (4q21.21) / LNPEP (5q15)
RASGEF1B (4q21.21) / MTOR (1p36.22)MNAT1 14q23.1 / RASGEF1B 4q21.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RASGEF1B   24881
Cards
Entrez_Gene (NCBI)RASGEF1B  153020  RasGEF domain family member 1B
AliasesGPIG4
GeneCards (Weizmann)RASGEF1B
Ensembl hg19 (Hinxton)ENSG00000138670 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138670 [Gene_View]  chr4:81426393-81471928 [Contig_View]  RASGEF1B [Vega]
ICGC DataPortalENSG00000138670
TCGA cBioPortalRASGEF1B
AceView (NCBI)RASGEF1B
Genatlas (Paris)RASGEF1B
WikiGenes153020
SOURCE (Princeton)RASGEF1B
Genetics Home Reference (NIH)RASGEF1B
Genomic and cartography
GoldenPath hg38 (UCSC)RASGEF1B  -     chr4:81426393-81471928 -  4q21.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASGEF1B  -     4q21.21   [Description]    (hg19-Feb_2009)
EnsemblRASGEF1B - 4q21.21 [CytoView hg19]  RASGEF1B - 4q21.21 [CytoView hg38]
Mapping of homologs : NCBIRASGEF1B [Mapview hg19]  RASGEF1B [Mapview hg38]
OMIM614532   
Gene and transcription
Genbank (Entrez)AK056257 AK291459 AK303625 BC036784 BC121003
RefSeq transcript (Entrez)NM_001300735 NM_001300736 NM_152545
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RASGEF1B
Cluster EST : UnigeneHs.591696 [ NCBI ]
CGAP (NCI)Hs.591696
Alternative Splicing GalleryENSG00000138670
Gene ExpressionRASGEF1B [ NCBI-GEO ]   RASGEF1B [ EBI - ARRAY_EXPRESS ]   RASGEF1B [ SEEK ]   RASGEF1B [ MEM ]
Gene Expression Viewer (FireBrowse)RASGEF1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)153020
GTEX Portal (Tissue expression)RASGEF1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ0VAM2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ0VAM2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ0VAM2
Splice isoforms : SwissVarQ0VAM2
PhosPhoSitePlusQ0VAM2
Domaine pattern : Prosite (Expaxy)RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)Ras-like_Gua-exchang_fac_N    Ras_G-nucl-exch_fac_CS    Ras_GEF_dom    RASGEF_cat_dom    RGF1B   
Domain families : Pfam (Sanger)RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam00617    pfam00618   
Domain families : Smart (EMBL)RasGEF (SM00147)  RasGEFN (SM00229)  
Conserved Domain (NCBI)RASGEF1B
DMDM Disease mutations153020
Blocks (Seattle)RASGEF1B
SuperfamilyQ0VAM2
Human Protein AtlasENSG00000138670
Peptide AtlasQ0VAM2
HPRD17955
IPIIPI00289097   IPI00855931   IPI00855959   IPI00384200   IPI00965716   
Protein Interaction databases
DIP (DOE-UCLA)Q0VAM2
IntAct (EBI)Q0VAM2
FunCoupENSG00000138670
BioGRIDRASGEF1B
STRING (EMBL)RASGEF1B
ZODIACRASGEF1B
Ontologies - Pathways
QuickGOQ0VAM2
Ontology : AmiGORas guanyl-nucleotide exchange factor activity  early endosome  late endosome  small GTPase mediated signal transduction  midbody  positive regulation of GTPase activity  
Ontology : EGO-EBIRas guanyl-nucleotide exchange factor activity  early endosome  late endosome  small GTPase mediated signal transduction  midbody  positive regulation of GTPase activity  
NDEx NetworkRASGEF1B
Atlas of Cancer Signalling NetworkRASGEF1B
Wikipedia pathwaysRASGEF1B
Orthology - Evolution
OrthoDB153020
GeneTree (enSembl)ENSG00000138670
Phylogenetic Trees/Animal Genes : TreeFamRASGEF1B
HOVERGENQ0VAM2
HOGENOMQ0VAM2
Homologs : HomoloGeneRASGEF1B
Homology/Alignments : Family Browser (UCSC)RASGEF1B
Gene fusions - Rearrangements
Fusion : MitelmanMNAT1/RASGEF1B [14q23.1/4q21.21]  [t(4;14)(q21;q23)]  
Fusion: TCGAMNAT1 14q23.1 RASGEF1B 4q21.21 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASGEF1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASGEF1B
dbVarRASGEF1B
ClinVarRASGEF1B
1000_GenomesRASGEF1B 
Exome Variant ServerRASGEF1B
ExAC (Exome Aggregation Consortium)RASGEF1B (select the gene name)
Genetic variants : HAPMAP153020
Genomic Variants (DGV)RASGEF1B [DGVbeta]
DECIPHERRASGEF1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASGEF1B 
Mutations
ICGC Data PortalRASGEF1B 
TCGA Data PortalRASGEF1B 
Broad Tumor PortalRASGEF1B
OASIS PortalRASGEF1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASGEF1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASGEF1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASGEF1B
DgiDB (Drug Gene Interaction Database)RASGEF1B
DoCM (Curated mutations)RASGEF1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASGEF1B (select a term)
intoGenRASGEF1B
Cancer3DRASGEF1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614532   
Orphanet
MedgenRASGEF1B
Genetic Testing Registry RASGEF1B
NextProtQ0VAM2 [Medical]
TSGene153020
GENETestsRASGEF1B
Target ValidationRASGEF1B
Huge Navigator RASGEF1B [HugePedia]
snp3D : Map Gene to Disease153020
BioCentury BCIQRASGEF1B
ClinGenRASGEF1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD153020
Chemical/Pharm GKB GenePA134927621
Clinical trialRASGEF1B
Miscellaneous
canSAR (ICR)RASGEF1B (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASGEF1B
EVEXRASGEF1B
GoPubMedRASGEF1B
iHOPRASGEF1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:12:37 CEST 2017

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