Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2)

Identity

Alias_symbol (synonym)GRF2
Ras-GRF2
Other aliasRAS-GRF2
HGNC (Hugo) RASGRF2
LocusID (NCBI) 5924
Atlas_Id 43454
Location 5q14.1  [Link to chromosome band 5q14]
Location_base_pair Starts at 80960689 and ends at 81230162 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCNB1IP1 (14q11.2) / RASGRF2 (5q14.1)RASGRF2 (5q14.1) / MBP (18q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RASGRF2   9876
Cards
Entrez_Gene (NCBI)RASGRF2  5924  Ras protein specific guanine nucleotide releasing factor 2
AliasesGRF2; RAS-GRF2
GeneCards (Weizmann)RASGRF2
Ensembl hg19 (Hinxton)ENSG00000113319 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113319 [Gene_View]  ENSG00000113319 [Sequence]  chr5:80960689-81230162 [Contig_View]  RASGRF2 [Vega]
ICGC DataPortalENSG00000113319
TCGA cBioPortalRASGRF2
AceView (NCBI)RASGRF2
Genatlas (Paris)RASGRF2
WikiGenes5924
SOURCE (Princeton)RASGRF2
Genetics Home Reference (NIH)RASGRF2
Genomic and cartography
GoldenPath hg38 (UCSC)RASGRF2  -     chr5:80960689-81230162 +  5q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASGRF2  -     5q14.1   [Description]    (hg19-Feb_2009)
GoldenPathRASGRF2 - 5q14.1 [CytoView hg19]  RASGRF2 - 5q14.1 [CytoView hg38]
ImmunoBaseENSG00000113319
Mapping of homologs : NCBIRASGRF2 [Mapview hg19]  RASGRF2 [Mapview hg38]
OMIM606614   
Gene and transcription
Genbank (Entrez)AF023130 AF181250 AF186017 AK094809 AL598102
RefSeq transcript (Entrez)NM_006909
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RASGRF2
Cluster EST : UnigeneHs.684592 [ NCBI ]
CGAP (NCI)Hs.684592
Alternative Splicing GalleryENSG00000113319
Gene ExpressionRASGRF2 [ NCBI-GEO ]   RASGRF2 [ EBI - ARRAY_EXPRESS ]   RASGRF2 [ SEEK ]   RASGRF2 [ MEM ]
Gene Expression Viewer (FireBrowse)RASGRF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5924
GTEX Portal (Tissue expression)RASGRF2
Human Protein AtlasENSG00000113319-RASGRF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14827   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14827  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14827
Splice isoforms : SwissVarO14827
PhosPhoSitePlusO14827
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    IQ (PS50096)    PH_DOMAIN (PS50003)    RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    IQ_motif_EF-hand-BS    PH-like_dom_sf    PH_domain    Ras-like_Gua-exchang_fac_N    Ras_G-nucl-exch_fac_CS    Ras_GEF_dom_sf    RASGEF_cat_dom    RASGEF_cat_dom_sf    RasGRF2   
Domain families : Pfam (Sanger)PH (PF00169)    RasGEF (PF00617)    RasGEF_N (PF00618)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00169    pfam00617    pfam00618    pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RasGEF (SM00147)  RasGEFN (SM00229)  RhoGEF (SM00325)  
Conserved Domain (NCBI)RASGRF2
DMDM Disease mutations5924
Blocks (Seattle)RASGRF2
SuperfamilyO14827
Human Protein Atlas [tissue]ENSG00000113319-RASGRF2 [tissue]
Peptide AtlasO14827
HPRD07588
IPIIPI00024184   IPI00968165   
Protein Interaction databases
DIP (DOE-UCLA)O14827
IntAct (EBI)O14827
FunCoupENSG00000113319
BioGRIDRASGRF2
STRING (EMBL)RASGRF2
ZODIACRASGRF2
Ontologies - Pathways
QuickGOO14827
Ontology : AmiGOMAPK cascade  Ras guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  calmodulin binding  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  plasma membrane  G protein-coupled receptor signaling pathway  small GTPase mediated signal transduction  response to endoplasmic reticulum stress  regulation of Rho protein signal transduction  positive regulation of apoptotic process  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIMAPK cascade  Ras guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  calmodulin binding  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  plasma membrane  G protein-coupled receptor signaling pathway  small GTPase mediated signal transduction  response to endoplasmic reticulum stress  regulation of Rho protein signal transduction  positive regulation of apoptotic process  regulation of small GTPase mediated signal transduction  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway   
NDEx NetworkRASGRF2
Atlas of Cancer Signalling NetworkRASGRF2
Wikipedia pathwaysRASGRF2
Orthology - Evolution
OrthoDB5924
GeneTree (enSembl)ENSG00000113319
Phylogenetic Trees/Animal Genes : TreeFamRASGRF2
HOGENOMO14827
Homologs : HomoloGeneRASGRF2
Homology/Alignments : Family Browser (UCSC)RASGRF2
Gene fusions - Rearrangements
Fusion : QuiverRASGRF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASGRF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASGRF2
dbVarRASGRF2
ClinVarRASGRF2
1000_GenomesRASGRF2 
Exome Variant ServerRASGRF2
ExAC (Exome Aggregation Consortium)ENSG00000113319
GNOMAD BrowserENSG00000113319
Varsome BrowserRASGRF2
Genetic variants : HAPMAP5924
Genomic Variants (DGV)RASGRF2 [DGVbeta]
DECIPHERRASGRF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASGRF2 
Mutations
ICGC Data PortalRASGRF2 
TCGA Data PortalRASGRF2 
Broad Tumor PortalRASGRF2
OASIS PortalRASGRF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASGRF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRASGRF2
Mutations and Diseases : HGMDRASGRF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASGRF2
DgiDB (Drug Gene Interaction Database)RASGRF2
DoCM (Curated mutations)RASGRF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASGRF2 (select a term)
intoGenRASGRF2
Cancer3DRASGRF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606614   
Orphanet
DisGeNETRASGRF2
MedgenRASGRF2
Genetic Testing Registry RASGRF2
NextProtO14827 [Medical]
TSGene5924
GENETestsRASGRF2
Target ValidationRASGRF2
Huge Navigator RASGRF2 [HugePedia]
snp3D : Map Gene to Disease5924
BioCentury BCIQRASGRF2
ClinGenRASGRF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5924
Chemical/Pharm GKB GenePA34239
Clinical trialRASGRF2
Miscellaneous
canSAR (ICR)RASGRF2 (select the gene name)
DataMed IndexRASGRF2
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASGRF2
EVEXRASGRF2
GoPubMedRASGRF2
iHOPRASGRF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:04:15 CET 2019
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