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RASGRP1 (RAS guanyl releasing protein 1)

Identity

Alias_namesRAS guanyl releasing protein 1 (calcium and DAG-regulated)
Alias_symbol (synonym)CalDAG-GEFII
RASGRP
HGNC (Hugo) RASGRP1
LocusID (NCBI) 10125
Atlas_Id 43455
Location 15q14  [Link to chromosome band 15q14]
Location_base_pair Starts at 38780302 and ends at 38857007 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAM98B (15q14) / RASGRP1 (15q14)RASGRP1 (15q14) / LRRC4C (11p12)FAM98B 15q14 / RASGRP1 15q14
RASGRP1 15q14 / LRRC4C 11p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RASGRP1   9878
Cards
Entrez_Gene (NCBI)RASGRP1  10125  RAS guanyl releasing protein 1
AliasesCALDAG-GEFI; CALDAG-GEFII; RASGRP; V; 
hRasGRP1
GeneCards (Weizmann)RASGRP1
Ensembl hg19 (Hinxton)ENSG00000172575 [Gene_View]  chr15:38780302-38857007 [Contig_View]  RASGRP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172575 [Gene_View]  chr15:38780302-38857007 [Contig_View]  RASGRP1 [Vega]
ICGC DataPortalENSG00000172575
TCGA cBioPortalRASGRP1
AceView (NCBI)RASGRP1
Genatlas (Paris)RASGRP1
WikiGenes10125
SOURCE (Princeton)RASGRP1
Genetics Home Reference (NIH)RASGRP1
Genomic and cartography
GoldenPath hg19 (UCSC)RASGRP1  -     chr15:38780302-38857007 -  15q14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RASGRP1  -     15q14   [Description]    (hg38-Dec_2013)
EnsemblRASGRP1 - 15q14 [CytoView hg19]  RASGRP1 - 15q14 [CytoView hg38]
Mapping of homologs : NCBIRASGRP1 [Mapview hg19]  RASGRP1 [Mapview hg38]
OMIM603962   
Gene and transcription
Genbank (Entrez)AA742351 AB208848 AF081195 AF081197 AF106071
RefSeq transcript (Entrez)NM_001128602 NM_001306086 NM_005739
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_023268 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)RASGRP1
Cluster EST : UnigeneHs.591127 [ NCBI ]
CGAP (NCI)Hs.591127
Alternative Splicing GalleryENSG00000172575
Gene ExpressionRASGRP1 [ NCBI-GEO ]   RASGRP1 [ EBI - ARRAY_EXPRESS ]   RASGRP1 [ SEEK ]   RASGRP1 [ MEM ]
Gene Expression Viewer (FireBrowse)RASGRP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10125
GTEX Portal (Tissue expression)RASGRP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95267   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95267  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95267
Splice isoforms : SwissVarO95267
PhosPhoSitePlusO95267
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    PE/DAG-bd    Ras-like_Gua-exchang_fac_N    Ras_GEF_dom    RASGEF_cat_dom    RasGRP1   
Domain families : Pfam (Sanger)C1_1 (PF00130)    RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam00130    pfam00617    pfam00618   
Domain families : Smart (EMBL)C1 (SM00109)  RasGEF (SM00147)  RasGEFN (SM00229)  
Conserved Domain (NCBI)RASGRP1
DMDM Disease mutations10125
Blocks (Seattle)RASGRP1
PDB (SRS)4L9M    4L9U   
PDB (PDBSum)4L9M    4L9U   
PDB (IMB)4L9M    4L9U   
PDB (RSDB)4L9M    4L9U   
Structural Biology KnowledgeBase4L9M    4L9U   
SCOP (Structural Classification of Proteins)4L9M    4L9U   
CATH (Classification of proteins structures)4L9M    4L9U   
SuperfamilyO95267
Human Protein AtlasENSG00000172575
Peptide AtlasO95267
HPRD04909
IPIIPI00024733   IPI00885149   IPI00885132   IPI00885115   IPI00885089   IPI00953527   IPI00952817   IPI01015429   IPI01015803   
Protein Interaction databases
DIP (DOE-UCLA)O95267
IntAct (EBI)O95267
FunCoupENSG00000172575
BioGRIDRASGRP1
STRING (EMBL)RASGRP1
ZODIACRASGRP1
Ontologies - Pathways
QuickGOO95267
Ontology : AmiGOGolgi membrane  MAPK cascade  phosphatidylserine binding  cytokine production  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  inflammatory response to antigenic stimulus  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  signal transduction  Ras protein signal transduction  zinc ion binding  lipid binding  regulation of phosphatidylinositol 3-kinase signaling  membrane  diacylglycerol binding  cell differentiation  phosphatidylcholine binding  secretory granule localization  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of tumor necrosis factor production  positive regulation of natural killer cell differentiation  positive regulation of T cell differentiation in thymus  mast cell granule  protein homodimerization activity  mast cell degranulation  positive regulation of MAP kinase activity  positive regulation of GTPase activity  positive regulation of natural killer cell mediated cytotoxicity  positive regulation of JNK cascade  positive regulation of Ras protein signal transduction  vesicle transport along microtubule  protein oligomerization  regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  activation of GTPase activity  activation of GTPase activity  regulation of phospholipase C activity  regulation of p38MAPK cascade  positive regulation of interferon-gamma secretion  
Ontology : EGO-EBIGolgi membrane  MAPK cascade  phosphatidylserine binding  cytokine production  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  inflammatory response to antigenic stimulus  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  signal transduction  Ras protein signal transduction  zinc ion binding  lipid binding  regulation of phosphatidylinositol 3-kinase signaling  membrane  diacylglycerol binding  cell differentiation  phosphatidylcholine binding  secretory granule localization  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of tumor necrosis factor production  positive regulation of natural killer cell differentiation  positive regulation of T cell differentiation in thymus  mast cell granule  protein homodimerization activity  mast cell degranulation  positive regulation of MAP kinase activity  positive regulation of GTPase activity  positive regulation of natural killer cell mediated cytotoxicity  positive regulation of JNK cascade  positive regulation of Ras protein signal transduction  vesicle transport along microtubule  protein oligomerization  regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  activation of GTPase activity  activation of GTPase activity  regulation of phospholipase C activity  regulation of p38MAPK cascade  positive regulation of interferon-gamma secretion  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    T cell receptor signaling pathway   
NDEx NetworkRASGRP1
Atlas of Cancer Signalling NetworkRASGRP1
Wikipedia pathwaysRASGRP1
Orthology - Evolution
OrthoDB10125
GeneTree (enSembl)ENSG00000172575
Phylogenetic Trees/Animal Genes : TreeFamRASGRP1
HOVERGENO95267
HOGENOMO95267
Homologs : HomoloGeneRASGRP1
Homology/Alignments : Family Browser (UCSC)RASGRP1
Gene fusions - Rearrangements
Fusion: TCGAFAM98B 15q14 RASGRP1 15q14 BRCA
Fusion: TCGARASGRP1 15q14 LRRC4C 11p12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASGRP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASGRP1
dbVarRASGRP1
ClinVarRASGRP1
1000_GenomesRASGRP1 
Exome Variant ServerRASGRP1
ExAC (Exome Aggregation Consortium)RASGRP1 (select the gene name)
Genetic variants : HAPMAP10125
Genomic Variants (DGV)RASGRP1 [DGVbeta]
DECIPHER (Syndromes)15:38780302-38857007  ENSG00000172575
CONAN: Copy Number AnalysisRASGRP1 
Mutations
ICGC Data PortalRASGRP1 
TCGA Data PortalRASGRP1 
Broad Tumor PortalRASGRP1
OASIS PortalRASGRP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASGRP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASGRP1
intOGen PortalRASGRP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASGRP1
DgiDB (Drug Gene Interaction Database)RASGRP1
DoCM (Curated mutations)RASGRP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASGRP1 (select a term)
intoGenRASGRP1
Cancer3DRASGRP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603962   
Orphanet
MedgenRASGRP1
Genetic Testing Registry RASGRP1
NextProtO95267 [Medical]
TSGene10125
GENETestsRASGRP1
Huge Navigator RASGRP1 [HugePedia]
snp3D : Map Gene to Disease10125
BioCentury BCIQRASGRP1
ClinGenRASGRP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10125
Chemical/Pharm GKB GenePA34240
Clinical trialRASGRP1
Miscellaneous
canSAR (ICR)RASGRP1 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASGRP1
EVEXRASGRP1
GoPubMedRASGRP1
iHOPRASGRP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:49:32 CET 2016

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