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RASGRP1 (RAS guanyl releasing protein 1 (calcium and DAG-regulated))

Identity

Other namesCALDAG-GEFI
CALDAG-GEFII
RASGRP
V
hRasGRP1
HGNC (Hugo) RASGRP1
LocusID (NCBI) 10125
Atlas_Id 43455
Location 15q14
Location_base_pair Starts at 38780302 and ends at 38857007 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
FAM98B 15q14 / RASGRP1 15q14RASGRP1 15q14 / LRRC4C 11p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RASGRP1   9878
Cards
Entrez_Gene (NCBI)RASGRP1  10125  RAS guanyl releasing protein 1 (calcium and DAG-regulated)
GeneCards (Weizmann)RASGRP1
Ensembl hg19 (Hinxton)ENSG00000172575 [Gene_View]  chr15:38780302-38857007 [Contig_View]  RASGRP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172575 [Gene_View]  chr15:38780302-38857007 [Contig_View]  RASGRP1 [Vega]
ICGC DataPortalENSG00000172575
TCGA cBioPortalRASGRP1
AceView (NCBI)RASGRP1
Genatlas (Paris)RASGRP1
WikiGenes10125
SOURCE (Princeton)RASGRP1
Genomic and cartography
GoldenPath hg19 (UCSC)RASGRP1  -     chr15:38780302-38857007 -  15q14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RASGRP1  -     15q14   [Description]    (hg38-Dec_2013)
EnsemblRASGRP1 - 15q14 [CytoView hg19]  RASGRP1 - 15q14 [CytoView hg38]
Mapping of homologs : NCBIRASGRP1 [Mapview hg19]  RASGRP1 [Mapview hg38]
OMIM603962   
Gene and transcription
Genbank (Entrez)AA742351 AB208848 AF081195 AF081197 AF106071
RefSeq transcript (Entrez)NM_001128602 NM_001306086 NM_005739
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_023268 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)RASGRP1
Cluster EST : UnigeneHs.591127 [ NCBI ]
CGAP (NCI)Hs.591127
Alternative Splicing : Fast-db (Paris)GSHG0010309
Alternative Splicing GalleryENSG00000172575
Gene ExpressionRASGRP1 [ NCBI-GEO ]     RASGRP1 [ SEEK ]   RASGRP1 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)10125
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95267 (Uniprot)
NextProtO95267  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95267
Splice isoforms : SwissVarO95267 (Swissvar)
PhosPhoSitePlusO95267
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    PE/DAG-bd    Ras-like_Gua-exchang_fac_N    Ras_GEF_dom    RASGEF_cat_dom    RasGRP1   
Domain families : Pfam (Sanger)C1_1 (PF00130)    EF-hand_6 (PF13405)    RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam00130    pfam13405    pfam00617    pfam00618   
Domain families : Smart (EMBL)C1 (SM00109)  RasGEF (SM00147)  RasGEFN (SM00229)  
DMDM Disease mutations10125
Blocks (Seattle)RASGRP1
PDB (SRS)4L9M    4L9U   
PDB (PDBSum)4L9M    4L9U   
PDB (IMB)4L9M    4L9U   
PDB (RSDB)4L9M    4L9U   
Structural Biology KnowledgeBase4L9M    4L9U   
SCOP (Structural Classification of Proteins)4L9M    4L9U   
CATH (Classification of proteins structures)4L9M    4L9U   
Human Protein AtlasENSG00000172575
Peptide AtlasO95267
HPRD04909
IPIIPI00024733   IPI00885149   IPI00885132   IPI00885115   IPI00885089   IPI00953527   IPI00952817   IPI01015429   IPI01015803   
Protein Interaction databases
DIP (DOE-UCLA)O95267
IntAct (EBI)O95267
FunCoupENSG00000172575
BioGRIDRASGRP1
IntegromeDBRASGRP1
STRING (EMBL)RASGRP1
ZODIACRASGRP1
Ontologies - Pathways
QuickGOO95267
Ontology : AmiGOGolgi membrane  MAPK cascade  activation of MAPKK activity  phosphatidylserine binding  cytokine production  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  inflammatory response to antigenic stimulus  guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  blood coagulation  zinc ion binding  insulin receptor signaling pathway  lipid binding  fibroblast growth factor receptor signaling pathway  regulation of phosphatidylinositol 3-kinase signaling  membrane  diacylglycerol binding  platelet activation  phosphatidylcholine binding  secretory granule localization  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of tumor necrosis factor production  positive regulation of natural killer cell differentiation  positive regulation of T cell differentiation in thymus  Fc-epsilon receptor signaling pathway  mast cell granule  protein homodimerization activity  mast cell degranulation  positive regulation of MAP kinase activity  positive regulation of GTPase activity  innate immune response  positive regulation of natural killer cell mediated cytotoxicity  positive regulation of JNK cascade  positive regulation of Ras protein signal transduction  vesicle transport along microtubule  vascular endothelial growth factor receptor signaling pathway  neurotrophin TRK receptor signaling pathway  protein oligomerization  regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  activation of GTPase activity  activation of GTPase activity  regulation of phospholipase C activity  regulation of p38MAPK cascade  positive regulation of interferon-gamma secretion  
Ontology : EGO-EBIGolgi membrane  MAPK cascade  activation of MAPKK activity  phosphatidylserine binding  cytokine production  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  inflammatory response to antigenic stimulus  guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  endoplasmic reticulum membrane  Golgi apparatus  cytosol  plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  blood coagulation  zinc ion binding  insulin receptor signaling pathway  lipid binding  fibroblast growth factor receptor signaling pathway  regulation of phosphatidylinositol 3-kinase signaling  membrane  diacylglycerol binding  platelet activation  phosphatidylcholine binding  secretory granule localization  positive regulation of granulocyte macrophage colony-stimulating factor production  positive regulation of tumor necrosis factor production  positive regulation of natural killer cell differentiation  positive regulation of T cell differentiation in thymus  Fc-epsilon receptor signaling pathway  mast cell granule  protein homodimerization activity  mast cell degranulation  positive regulation of MAP kinase activity  positive regulation of GTPase activity  innate immune response  positive regulation of natural killer cell mediated cytotoxicity  positive regulation of JNK cascade  positive regulation of Ras protein signal transduction  vesicle transport along microtubule  vascular endothelial growth factor receptor signaling pathway  neurotrophin TRK receptor signaling pathway  protein oligomerization  regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  activation of GTPase activity  activation of GTPase activity  regulation of phospholipase C activity  regulation of p38MAPK cascade  positive regulation of interferon-gamma secretion  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    T cell receptor signaling pathway   
Protein Interaction DatabaseRASGRP1
Atlas of Cancer Signalling NetworkRASGRP1
Wikipedia pathwaysRASGRP1
Orthology - Evolution
OrthoDB10125
GeneTree (enSembl)ENSG00000172575
Phylogenetic Trees/Animal Genes : TreeFamRASGRP1
Homologs : HomoloGeneRASGRP1
Homology/Alignments : Family Browser (UCSC)RASGRP1
Gene fusions - Rearrangements
Fusion: TCGAFAM98B 15q14 RASGRP1 15q14 BRCA
Fusion: TCGARASGRP1 15q14 LRRC4C 11p12 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerRASGRP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASGRP1
dbVarRASGRP1
ClinVarRASGRP1
1000_GenomesRASGRP1 
Exome Variant ServerRASGRP1
Exome Aggregation Consortium (ExAC)ENSG00000172575
SNP (GeneSNP Utah)RASGRP1
SNP : HGBaseRASGRP1
Genetic variants : HAPMAPRASGRP1
Genomic Variants (DGV)RASGRP1 [DGVbeta]
Mutations
ICGC Data PortalRASGRP1 
TCGA Data PortalRASGRP1 
Tumor PortalRASGRP1
TCGA Copy Number PortalRASGRP1
Somatic Mutations in Cancer : COSMICRASGRP1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASGRP1
DgiDB (Drug Gene Interaction Database)RASGRP1
DoCM (Curated mutations)RASGRP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASGRP1 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:38780302-38857007
CONAN: Copy Number AnalysisRASGRP1 
Mutations and Diseases : HGMDRASGRP1
OMIM603962   
MedgenRASGRP1
NextProtO95267 [Medical]
TSGene10125
GENETestsRASGRP1
Huge Navigator RASGRP1 [HugePedia]  RASGRP1 [HugeCancerGEM]
snp3D : Map Gene to Disease10125
BioCentury BCIQRASGRP1
General knowledge
Chemical/Protein Interactions : CTD10125
Chemical/Pharm GKB GenePA34240
Clinical trialRASGRP1
Other databases
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASGRP1
GoPubMedRASGRP1
iHOPRASGRP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 19:22:38 CET 2016

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