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RASGRP1 (RAS guanyl releasing protein 1 (calcium and DAG-regulated))

Identity

Other namesCALDAG-GEFI
CALDAG-GEFII
RASGRP
V
hRasGRP1
HGNC (Hugo) RASGRP1
LocusID (NCBI) 10125
Location 15q14
Location_base_pair Starts at 38780302 and ends at 38857007 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RASGRP1   9878
Cards
Entrez_Gene (NCBI)RASGRP1  10125  RAS guanyl releasing protein 1 (calcium and DAG-regulated)
GeneCards (Weizmann)RASGRP1
Ensembl (Hinxton)ENSG00000172575 [Gene_View]  chr15:38780302-38857007 [Contig_View]  RASGRP1 [Vega]
AceView (NCBI)RASGRP1
Genatlas (Paris)RASGRP1
WikiGenes10125
SOURCE (Princeton)NM_001128602 NM_005739
Genomic and cartography
GoldenPath (UCSC)RASGRP1  -  15q14   chr15:38780302-38857007 -  15q14   [Description]    (hg19-Feb_2009)
EnsemblRASGRP1 - 15q14 [CytoView]
Mapping of homologs : NCBIRASGRP1 [Mapview]
OMIM603962   
Gene and transcription
Genbank (Entrez)AA742351 AB208848 AF081195 AF081197 AF106071
RefSeq transcript (Entrez)NM_001128602 NM_005739
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_023268 NT_010194 NW_001838214 NW_004929398
Consensus coding sequences : CCDS (NCBI)RASGRP1
Cluster EST : UnigeneHs.591127 [ NCBI ]
CGAP (NCI)Hs.591127
Alternative Splicing : Fast-db (Paris)GSHG0010309
Alternative Splicing GalleryENSG00000172575
Gene ExpressionRASGRP1 [ NCBI-GEO ]     RASGRP1 [ SEEK ]   RASGRP1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95267 (Uniprot)
NextProtO95267  [Medical]
With graphics : InterProO95267
Splice isoforms : SwissVarO95267 (Swissvar)
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    RASGEF (PS00720)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    Prot_Kinase_C-like_PE/DAG-bd    Ras-like_Gua-exchang_fac_N    Ras_GEF    Ras_GEF_dom    RasGRF_CDC25   
Related proteins : CluSTrO95267
Domain families : Pfam (Sanger)C1_1 (PF00130)    EF-hand_6 (PF13405)    RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam00130    pfam13405    pfam00617    pfam00618   
Domain families : Smart (EMBL)C1 (SM00109)  RasGEF (SM00147)  RasGEFN (SM00229)  
DMDM Disease mutations10125
Blocks (Seattle)O95267
Human Protein AtlasENSG00000172575
Peptide AtlasO95267
HPRD04909
IPIIPI00024733   IPI00885149   IPI00885132   IPI00885115   IPI00885089   IPI00953527   IPI00952817   IPI01015429   IPI01015803   
Protein Interaction databases
DIP (DOE-UCLA)O95267
IntAct (EBI)O95267
FunCoupENSG00000172575
BioGRIDRASGRP1
InParanoidO95267
Interologous Interaction database O95267
IntegromeDBRASGRP1
STRING (EMBL)RASGRP1
Ontologies - Pathways
Ontology : AmiGOGolgi membrane  cytokine production  inflammatory response to antigenic stimulus  guanyl-nucleotide exchange factor activity  calcium ion binding  endoplasmic reticulum membrane  cytosol  plasma membrane  signal transduction  Ras protein signal transduction  blood coagulation  lipid binding  regulation of phosphatidylinositol 3-kinase cascade  membrane  cell differentiation  platelet activation  secretory granule localization  activation of Rho GTPase activity  Fc-epsilon receptor signaling pathway  mast cell degranulation  innate immune response  vesicle transport along microtubule  
Ontology : EGO-EBIGolgi membrane  cytokine production  inflammatory response to antigenic stimulus  guanyl-nucleotide exchange factor activity  calcium ion binding  endoplasmic reticulum membrane  cytosol  plasma membrane  signal transduction  Ras protein signal transduction  blood coagulation  lipid binding  regulation of phosphatidylinositol 3-kinase cascade  membrane  cell differentiation  platelet activation  secretory granule localization  activation of Rho GTPase activity  Fc-epsilon receptor signaling pathway  mast cell degranulation  innate immune response  vesicle transport along microtubule  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    T cell receptor signaling pathway   
REACTOMERASGRP1
Protein Interaction DatabaseRASGRP1
Wikipedia pathwaysRASGRP1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RASGRP1
SNP (GeneSNP Utah)RASGRP1
SNP : HGBaseRASGRP1
Genetic variants : HAPMAPRASGRP1
1000_GenomesRASGRP1 
ICGC programENSG00000172575 
Somatic Mutations in Cancer : COSMICRASGRP1 
CONAN: Copy Number AnalysisRASGRP1 
Mutations and Diseases : HGMDRASGRP1
OMIM603962   
GENETestsRASGRP1
Disease Genetic AssociationRASGRP1
Huge Navigator RASGRP1 [HugePedia]  RASGRP1 [HugeCancerGEM]
Genomic VariantsRASGRP1  RASGRP1 [DGVbeta]
Exome VariantRASGRP1
dbVarRASGRP1
ClinVarRASGRP1
snp3D : Map Gene to Disease10125
General knowledge
Homologs : HomoloGeneRASGRP1
Homology/Alignments : Family Browser (UCSC)RASGRP1
Phylogenetic Trees/Animal Genes : TreeFamRASGRP1
Chemical/Protein Interactions : CTD10125
Chemical/Pharm GKB GenePA34240
Clinical trialRASGRP1
Cancer Resource (Charite)ENSG00000172575
Other databases
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
CoreMineRASGRP1
iHOPRASGRP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:13:20 CEST 2014

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