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RASGRP2 (RAS guanyl releasing protein 2 (calcium and DAG-regulated))

Identity

Other namesCALDAG-GEFI
CDC25L
HGNC (Hugo) RASGRP2
LocusID (NCBI) 10235
Location 11q13.1
Location_base_pair Starts at 64494383 and ends at 64512329 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RASGRP2   9879
Cards
Entrez_Gene (NCBI)RASGRP2  10235  RAS guanyl releasing protein 2 (calcium and DAG-regulated)
GeneCards (Weizmann)RASGRP2
Ensembl (Hinxton)ENSG00000068831 [Gene_View]  chr11:64494383-64512329 [Contig_View]  RASGRP2 [Vega]
ICGC DataPortalENSG00000068831
cBioPortalRASGRP2
AceView (NCBI)RASGRP2
Genatlas (Paris)RASGRP2
WikiGenes10235
SOURCE (Princeton)NM_001098670 NM_001098671 NM_005825 NM_153819
Genomic and cartography
GoldenPath (UCSC)RASGRP2  -  11q13.1   chr11:64494383-64512329 -  11q13.1   [Description]    (hg19-Feb_2009)
EnsemblRASGRP2 - 11q13.1 [CytoView]
Mapping of homologs : NCBIRASGRP2 [Mapview]
OMIM605577   615888   
Gene and transcription
Genbank (Entrez)AF043722 AF043723 AF081194 AK092852 AK092882
RefSeq transcript (Entrez)NM_001098670 NM_001098671 NM_005825 NM_153819
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_007574 NT_167190 NW_001838025 NW_004929380
Consensus coding sequences : CCDS (NCBI)RASGRP2
Cluster EST : UnigeneHs.99491 [ NCBI ]
CGAP (NCI)Hs.99491
Alternative Splicing : Fast-db (Paris)GSHG0005876
Alternative Splicing GalleryENSG00000068831
Gene ExpressionRASGRP2 [ NCBI-GEO ]     RASGRP2 [ SEEK ]   RASGRP2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7LDG7 (Uniprot)
NextProtQ7LDG7  [Medical]
With graphics : InterProQ7LDG7
Splice isoforms : SwissVarQ7LDG7 (Swissvar)
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)EF-hand-dom_pair [organisation]   EF_Hand_1_Ca_BS [organisation]   EF_hand_dom [organisation]   Prot_Kinase_C-like_PE/DAG-bd [organisation]   Ras-like_Gua-exchang_fac_N [organisation]   Ras_GEF_dom [organisation]   RasGRF_CDC25 [organisation]  
Related proteins : CluSTrQ7LDG7
Domain families : Pfam (Sanger)C1_1 (PF00130)    EF-hand_5 (PF13202)    RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam00130    pfam13202    pfam00617    pfam00618   
Domain families : Smart (EMBL)C1 (SM00109)  EFh (SM00054)  RasGEF (SM00147)  RasGEFN (SM00229)  
DMDM Disease mutations10235
Blocks (Seattle)Q7LDG7
PDB (SRS)2MA2   
PDB (PDBSum)2MA2   
PDB (IMB)2MA2   
PDB (RSDB)2MA2   
Human Protein AtlasENSG00000068831 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ7LDG7
HPRD09278
IPIIPI00329757   IPI00854815   IPI00852607   IPI00642411   IPI00658101   IPI00658172   IPI00852879   IPI00853075   IPI00852753   IPI00852947   IPI00984510   IPI00892587   
Protein Interaction databases
DIP (DOE-UCLA)Q7LDG7
IntAct (EBI)Q7LDG7
FunCoupENSG00000068831
BioGRIDRASGRP2
InParanoidQ7LDG7
Interologous Interaction database Q7LDG7
IntegromeDBRASGRP2
STRING (EMBL)RASGRP2
Ontologies - Pathways
Ontology : AmiGOregulation of cell growth  guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  cytosol  cytosol  plasma membrane  signal transduction  Ras protein signal transduction  blood coagulation  lipid binding  diacylglycerol binding  cell junction  platelet activation  ruffle membrane  neuron projection  positive regulation of GTPase activity  positive regulation of GTPase activity  synapse  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIregulation of cell growth  guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  cytosol  cytosol  plasma membrane  signal transduction  Ras protein signal transduction  blood coagulation  lipid binding  diacylglycerol binding  cell junction  platelet activation  ruffle membrane  neuron projection  positive regulation of GTPase activity  positive regulation of GTPase activity  synapse  regulation of small GTPase mediated signal transduction  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway   
Protein Interaction DatabaseRASGRP2
Wikipedia pathwaysRASGRP2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RASGRP2
snp3D : Map Gene to Disease10235
SNP (GeneSNP Utah)RASGRP2
SNP : HGBaseRASGRP2
Genetic variants : HAPMAPRASGRP2
Exome VariantRASGRP2
1000_GenomesRASGRP2 
ICGC programENSG00000068831 
Somatic Mutations in Cancer : COSMICRASGRP2 
CONAN: Copy Number AnalysisRASGRP2 
Mutations and Diseases : HGMDRASGRP2
Mutations and Diseases : intOGenRASGRP2
Genomic VariantsRASGRP2  RASGRP2 [DGVbeta]
dbVarRASGRP2
ClinVarRASGRP2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM605577    615888   
MedgenRASGRP2
GENETestsRASGRP2
Disease Genetic AssociationRASGRP2
Huge Navigator RASGRP2 [HugePedia]  RASGRP2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneRASGRP2
Homology/Alignments : Family Browser (UCSC)RASGRP2
Phylogenetic Trees/Animal Genes : TreeFamRASGRP2
Chemical/Protein Interactions : CTD10235
Chemical/Pharm GKB GenePA34241
Clinical trialRASGRP2
Cancer Resource (Charite)ENSG00000068831
Other databases
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
CoreMineRASGRP2
iHOPRASGRP2
OncoSearchRASGRP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:14:21 CEST 2014

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