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RASGRP2 (RAS guanyl releasing protein 2)

Identity

Alias (NCBI)CALDAG-GEFI
CDC25L
HGNC (Hugo) RASGRP2
HGNC Alias symbCALDAG-GEFI
HGNC Alias namecalcium- and diacylglycerol-regulated guanine nucleotide exchange factor I
HGNC Previous nameRAS guanyl releasing protein 2 (calcium and DAG-regulated)
LocusID (NCBI) 10235
Atlas_Id 43456
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64726911 and ends at 64745456 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RASGRP2   9879
LRG (Locus Reference Genomic)LRG_100
Cards
Entrez_Gene (NCBI)RASGRP2    RAS guanyl releasing protein 2
AliasesCALDAG-GEFI; CDC25L
GeneCards (Weizmann)RASGRP2
Ensembl hg19 (Hinxton)ENSG00000068831 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068831 [Gene_View]  ENSG00000068831 [Sequence]  chr11:64726911-64745456 [Contig_View]  RASGRP2 [Vega]
ICGC DataPortalENSG00000068831
TCGA cBioPortalRASGRP2
AceView (NCBI)RASGRP2
Genatlas (Paris)RASGRP2
SOURCE (Princeton)RASGRP2
Genetics Home Reference (NIH)RASGRP2
Genomic and cartography
GoldenPath hg38 (UCSC)RASGRP2  -     chr11:64726911-64745456 -  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASGRP2  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathRASGRP2 - 11q13.1 [CytoView hg19]  RASGRP2 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000068831
Genome Data Viewer NCBIRASGRP2 [Mapview hg19]  
OMIM605577   615888   
Gene and transcription
Genbank (Entrez)AF043722 AF043723 AF081194 AK092852 AK092882
RefSeq transcript (Entrez)NM_001098670 NM_001098671 NM_001318398 NM_005825 NM_153819
Consensus coding sequences : CCDS (NCBI)RASGRP2
Gene ExpressionRASGRP2 [ NCBI-GEO ]   RASGRP2 [ EBI - ARRAY_EXPRESS ]   RASGRP2 [ SEEK ]   RASGRP2 [ MEM ]
Gene Expression Viewer (FireBrowse)RASGRP2 [ Firebrowse - Broad ]
GenevisibleExpression of RASGRP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10235
GTEX Portal (Tissue expression)RASGRP2
Human Protein AtlasENSG00000068831-RASGRP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7LDG7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7LDG7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7LDG7
PhosPhoSitePlusQ7LDG7
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    PE/DAG-bd    Ras-like_GEF    Ras-like_Gua-exchang_fac_N    Ras_GEF_dom_sf    RASGEF_cat_dom    RASGEF_cat_dom_sf   
Domain families : Pfam (Sanger)C1_1 (PF00130)    EF-hand_7 (PF13499)    RasGEF (PF00617)    RasGEF_N (PF00618)   
Domain families : Pfam (NCBI)pfam00130    pfam13499    pfam00617    pfam00618   
Domain families : Smart (EMBL)C1 (SM00109)  EFh (SM00054)  RasGEF (SM00147)  RasGEFN (SM00229)  
Conserved Domain (NCBI)RASGRP2
PDB (RSDB)2MA2    6AXF   
PDB Europe2MA2    6AXF   
PDB (PDBSum)2MA2    6AXF   
PDB (IMB)2MA2    6AXF   
Structural Biology KnowledgeBase2MA2    6AXF   
SCOP (Structural Classification of Proteins)2MA2    6AXF   
CATH (Classification of proteins structures)2MA2    6AXF   
SuperfamilyQ7LDG7
AlphaFold pdb e-kbQ7LDG7   
Human Protein Atlas [tissue]ENSG00000068831-RASGRP2 [tissue]
HPRD09278
Protein Interaction databases
DIP (DOE-UCLA)Q7LDG7
IntAct (EBI)Q7LDG7
BioGRIDRASGRP2
STRING (EMBL)RASGRP2
ZODIACRASGRP2
Ontologies - Pathways
QuickGOQ7LDG7
Ontology : AmiGOregulation of cell growth  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  cytosol  cytosol  plasma membrane  plasma membrane  signal transduction  Ras protein signal transduction  Ras protein signal transduction  lipid binding  diacylglycerol binding  ruffle membrane  neuron projection  positive regulation of GTPase activity  positive regulation of GTPase activity  synapse  cellular response to calcium ion  
Ontology : EGO-EBIregulation of cell growth  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  calcium ion binding  calcium ion binding  cytosol  cytosol  plasma membrane  plasma membrane  signal transduction  Ras protein signal transduction  Ras protein signal transduction  lipid binding  diacylglycerol binding  ruffle membrane  neuron projection  positive regulation of GTPase activity  positive regulation of GTPase activity  synapse  cellular response to calcium ion  
Pathways : KEGGKEGG_MAPK_SIGNALING    KEGG_CHEMOKINE_SIGNALING   
NDEx NetworkRASGRP2
Atlas of Cancer Signalling NetworkRASGRP2
Wikipedia pathwaysRASGRP2
Orthology - Evolution
OrthoDB10235
GeneTree (enSembl)ENSG00000068831
Phylogenetic Trees/Animal Genes : TreeFamRASGRP2
Homologs : HomoloGeneRASGRP2
Homology/Alignments : Family Browser (UCSC)RASGRP2
Gene fusions - Rearrangements
Fusion : QuiverRASGRP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASGRP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASGRP2
dbVarRASGRP2
ClinVarRASGRP2
MonarchRASGRP2
1000_GenomesRASGRP2 
Exome Variant ServerRASGRP2
GNOMAD BrowserENSG00000068831
Varsome BrowserRASGRP2
ACMGRASGRP2 variants
VarityQ7LDG7
Genomic Variants (DGV)RASGRP2 [DGVbeta]
DECIPHERRASGRP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASGRP2 
Mutations
ICGC Data PortalRASGRP2 
TCGA Data PortalRASGRP2 
Broad Tumor PortalRASGRP2
OASIS PortalRASGRP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASGRP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRASGRP2
Mutations and Diseases : HGMDRASGRP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRASGRP2
DgiDB (Drug Gene Interaction Database)RASGRP2
DoCM (Curated mutations)RASGRP2
CIViC (Clinical Interpretations of Variants in Cancer)RASGRP2
Cancer3DRASGRP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605577    615888   
Orphanet23114   
DisGeNETRASGRP2
MedgenRASGRP2
Genetic Testing Registry RASGRP2
NextProtQ7LDG7 [Medical]
GENETestsRASGRP2
Target ValidationRASGRP2
Huge Navigator RASGRP2 [HugePedia]
ClinGenRASGRP2
Clinical trials, drugs, therapy
MyCancerGenomeRASGRP2
Protein Interactions : CTDRASGRP2
Pharm GKB GenePA34241
PharosQ7LDG7
Clinical trialRASGRP2
Miscellaneous
canSAR (ICR)RASGRP2
HarmonizomeRASGRP2
ARCHS4RASGRP2
DataMed IndexRASGRP2
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRASGRP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:55:28 CET 2022

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