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RASGRP3 (RAS guanyl releasing protein 3)

Identity

Alias_namesRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Alias_symbol (synonym)KIAA0846
GRP3
CalDAG-GEFIII
Other alias
HGNC (Hugo) RASGRP3
LocusID (NCBI) 25780
Atlas_Id 43457
Location 2p22.3  [Link to chromosome band 2p22]
Location_base_pair Starts at 33701321 and ends at 33789798 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RASGRP3 (2p22.3) / SECTM1 (17q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RASGRP3   14545
Cards
Entrez_Gene (NCBI)RASGRP3  25780  RAS guanyl releasing protein 3
AliasesGRP3
GeneCards (Weizmann)RASGRP3
Ensembl hg19 (Hinxton)ENSG00000152689 [Gene_View]  chr2:33701321-33789798 [Contig_View]  RASGRP3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000152689 [Gene_View]  chr2:33701321-33789798 [Contig_View]  RASGRP3 [Vega]
ICGC DataPortalENSG00000152689
TCGA cBioPortalRASGRP3
AceView (NCBI)RASGRP3
Genatlas (Paris)RASGRP3
WikiGenes25780
SOURCE (Princeton)RASGRP3
Genetics Home Reference (NIH)RASGRP3
Genomic and cartography
GoldenPath hg19 (UCSC)RASGRP3  -     chr2:33701321-33789798 +  2p22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RASGRP3  -     2p22.3   [Description]    (hg38-Dec_2013)
EnsemblRASGRP3 - 2p22.3 [CytoView hg19]  RASGRP3 - 2p22.3 [CytoView hg38]
Mapping of homologs : NCBIRASGRP3 [Mapview hg19]  RASGRP3 [Mapview hg38]
OMIM609531   
Gene and transcription
Genbank (Entrez)AA351079 AB020653 AK124316 AK125551 AK292983
RefSeq transcript (Entrez)NM_001139488 NM_015376 NM_170672
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)RASGRP3
Cluster EST : UnigeneHs.143674 [ NCBI ]
CGAP (NCI)Hs.143674
Alternative Splicing GalleryENSG00000152689
Gene ExpressionRASGRP3 [ NCBI-GEO ]   RASGRP3 [ EBI - ARRAY_EXPRESS ]   RASGRP3 [ SEEK ]   RASGRP3 [ MEM ]
Gene Expression Viewer (FireBrowse)RASGRP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25780
GTEX Portal (Tissue expression)RASGRP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IV61   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IV61  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IV61
Splice isoforms : SwissVarQ8IV61
PhosPhoSitePlusQ8IV61
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    PE/DAG-bd    Ras-like_Gua-exchang_fac_N    Ras_GEF_dom    RASGEF_cat_dom    RASGRP3   
Domain families : Pfam (Sanger)C1_1 (PF00130)    EF-hand_5 (PF13202)    RasGEF (PF00617)   
Domain families : Pfam (NCBI)pfam00130    pfam13202    pfam00617   
Domain families : Smart (EMBL)C1 (SM00109)  EFh (SM00054)  RasGEF (SM00147)  RasGEFN (SM00229)  
Conserved Domain (NCBI)RASGRP3
DMDM Disease mutations25780
Blocks (Seattle)RASGRP3
SuperfamilyQ8IV61
Human Protein AtlasENSG00000152689
Peptide AtlasQ8IV61
HPRD15213
IPIIPI00171874   IPI00892862   IPI00892591   IPI00892717   IPI00894391   IPI00893816   IPI00893964   IPI00893682   
Protein Interaction databases
DIP (DOE-UCLA)Q8IV61
IntAct (EBI)Q8IV61
FunCoupENSG00000152689
BioGRIDRASGRP3
STRING (EMBL)RASGRP3
ZODIACRASGRP3
Ontologies - Pathways
QuickGOQ8IV61
Ontology : AmiGOMAPK cascade  MAPK cascade  signal transducer activity  guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  GTPase activator activity  calcium ion binding  protein binding  plasma membrane  integral component of plasma membrane  small GTPase mediated signal transduction  Ras protein signal transduction  Ras GTPase binding  kinase binding  diacylglycerol binding  guanyl-nucleotide exchange factor complex  positive regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of GTPase activity  perinuclear region of cytoplasm  
Ontology : EGO-EBIMAPK cascade  MAPK cascade  signal transducer activity  guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  GTPase activator activity  calcium ion binding  protein binding  plasma membrane  integral component of plasma membrane  small GTPase mediated signal transduction  Ras protein signal transduction  Ras GTPase binding  kinase binding  diacylglycerol binding  guanyl-nucleotide exchange factor complex  positive regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of GTPase activity  perinuclear region of cytoplasm  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    B cell receptor signaling pathway   
NDEx NetworkRASGRP3
Atlas of Cancer Signalling NetworkRASGRP3
Wikipedia pathwaysRASGRP3
Orthology - Evolution
OrthoDB25780
GeneTree (enSembl)ENSG00000152689
Phylogenetic Trees/Animal Genes : TreeFamRASGRP3
HOVERGENQ8IV61
HOGENOMQ8IV61
Homologs : HomoloGeneRASGRP3
Homology/Alignments : Family Browser (UCSC)RASGRP3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASGRP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASGRP3
dbVarRASGRP3
ClinVarRASGRP3
1000_GenomesRASGRP3 
Exome Variant ServerRASGRP3
ExAC (Exome Aggregation Consortium)RASGRP3 (select the gene name)
Genetic variants : HAPMAP25780
Genomic Variants (DGV)RASGRP3 [DGVbeta]
DECIPHER (Syndromes)2:33701321-33789798  ENSG00000152689
CONAN: Copy Number AnalysisRASGRP3 
Mutations
ICGC Data PortalRASGRP3 
TCGA Data PortalRASGRP3 
Broad Tumor PortalRASGRP3
OASIS PortalRASGRP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASGRP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASGRP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASGRP3
DgiDB (Drug Gene Interaction Database)RASGRP3
DoCM (Curated mutations)RASGRP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASGRP3 (select a term)
intoGenRASGRP3
Cancer3DRASGRP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609531   
Orphanet
MedgenRASGRP3
Genetic Testing Registry RASGRP3
NextProtQ8IV61 [Medical]
TSGene25780
GENETestsRASGRP3
Huge Navigator RASGRP3 [HugePedia]
snp3D : Map Gene to Disease25780
BioCentury BCIQRASGRP3
ClinGenRASGRP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25780
Chemical/Pharm GKB GenePA134937092
Clinical trialRASGRP3
Miscellaneous
canSAR (ICR)RASGRP3 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASGRP3
EVEXRASGRP3
GoPubMedRASGRP3
iHOPRASGRP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:58 CEST 2017

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