RASGRP3 (RAS guanyl releasing protein 3 (calcium and DAG-regulated))

Identity

Other names	GRP3
	KIAA0846
HGNC	RASGRP3
Location	2p25.1-p24.1
Location_base_pair	Starts at 33514920 and ends at 33643162 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	RASGRP3   14545
Entrez_Gene	RASGRP3  25780  RAS guanyl releasing protein 3 (calcium and DAG-regulated)
	Cards
GeneCards	RASGRP3
Ensembl	ENSG00000133059 [Gene_View]  RASGRP3 [Vega]
Genatlas	RASGRP3
	Genomic and cartography
GoldenPath	RASGRP3  -     chr2:33514920-33643162 +  2p22.3   [Description]    (hg18-March_2006)
Ensembl	RASGRP3 - 2p22.3 [CytoView]
NCBI	Mapview
OMIM	609531 Disease map [OMIM]
HomoloGene	RASGRP3
	Gene and transcription
Genbank	AB020653 [ ENTREZ ]
Genbank	AK125551 [ ENTREZ ]
Genbank	AK292983 [ ENTREZ ]
Genbank	AM392579 [ ENTREZ ]
Genbank	BC027849 [ ENTREZ ]
RefSeq	NM_170672 [ SRS ]    NM_170672 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_022184 [ SRS ]    NT_022184 [ ENTREZ ]
RefSeq	NW_001838769 [ SRS ]    NW_001838769 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
CCDS	RASGRP3 CCDS - NCBI
AceView	RASGRP3 AceView - NCBI
Unigene	Hs.143674 [ SRS ]    Hs.143674 [ NCBI ]
Fast-db	3956 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q53SD7 [ SRS]    Q53SD7 [ EXPASY ]     Q53SD7 [ INTERPRO ]     Q53SD7 [ UNIPROT ] Q53SD7 [ VarSplice FASTA ]
Prosite	PS00018 EF_HAND_1 [ SRS ]    PS00018 EF_HAND_1 [ Expasy ]
Prosite	PS50222 EF_HAND_2 [ SRS ]    PS50222 EF_HAND_2 [ Expasy ]
Prosite	PS50009 RASGEF_CAT [ SRS ]    PS50009 RASGEF_CAT [ Expasy ]
Prosite	PS50212 RASGEF_NTER [ SRS ]    PS50212 RASGEF_NTER [ Expasy ]
Prosite	PS00479 ZF_DAG_PE_1 [ SRS ]    PS00479 ZF_DAG_PE_1 [ Expasy ]
Prosite	PS50081 ZF_DAG_PE_2 [ SRS ]    PS50081 ZF_DAG_PE_2 [ Expasy ]
Interpro	IPR002219 DAG_PE_bd [ SRS ]    IPR002219 DAG_PE_bd [ EBI ]
Interpro	IPR011992 EF-Hand_type [ SRS ]    IPR011992 EF-Hand_type [ EBI ]
Interpro	IPR002048 EF_hand_Ca_bd [ SRS ]    IPR002048 EF_hand_Ca_bd [ EBI ]
Interpro	IPR008937 Ras_GEF [ SRS ]    IPR008937 Ras_GEF [ EBI ]
Interpro	IPR000651 RasGef_N [ SRS ]    IPR000651 RasGef_N [ EBI ]
Interpro	IPR001895 RasGRF_CDC25 [ SRS ]    IPR001895 RasGRF_CDC25 [ EBI ]
CluSTr	Q53SD7
Pfam	PF00130 C1_1 [ SRS ]    PF00130 C1_1 [ Sanger ]    pfam00130 [ NCBI-CDD ]
Pfam	PF00036 efhand [ SRS ]    PF00036 efhand [ Sanger ]    pfam00036 [ NCBI-CDD ]
Pfam	PF00617 RasGEF [ SRS ]    PF00617 RasGEF [ Sanger ]    pfam00617 [ NCBI-CDD ]
Pfam	PF00618 RasGEF_N [ SRS ]    PF00618 RasGEF_N [ Sanger ]    pfam00618 [ NCBI-CDD ]
Smart	SM00109 C1 [EMBL]
Smart	SM00054 EFh [EMBL]
Smart	SM00147 RasGEF [EMBL]
Smart	SM00229 RasGEFN [EMBL]
Blocks	Q53SD7
HPRD	15213
	Protein Interaction databases
DIP	Q53SD7
IntAct	Q53SD7
	Polymorphism : SNP, mutations, diseases
OMIM	609531    [ map ]
GENETests	609531
SNP	RASGRP3 [dbSNP-NCBI]
SNP	NM_170672 [SNP-NCI]
SNP	RASGRP3 [GeneSNPs - Utah]  RASGRP3] [HGBASE - SRS]
HAPMAP	RASGRP3 [HAPMAP]
COSMIC	RASGRP3 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	RASGRP3
Genetic Association	RASGRP3
CDC HuGE	RASGRP3
	General knowledge
Family Browser	RASGRP3 [UCSC Family Browser]
SOURCE	NM_170672
SMD	Hs.143674
SAGE	Hs.143674
GO	MAPKKK cascade [Amigo]  MAPKKK cascade
GO	signal transducer activity [Amigo]  signal transducer activity
GO	Ras guanyl-nucleotide exchange factor activity [Amigo]  Ras guanyl-nucleotide exchange factor activity
GO	calcium ion binding [Amigo]  calcium ion binding
GO	protein binding [Amigo]  protein binding
GO	intracellular [Amigo]  intracellular
GO	cytoplasm [Amigo]  cytoplasm
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	Ras protein signal transduction [Amigo]  Ras protein signal transduction
GO	zinc ion binding [Amigo]  zinc ion binding
GO	Ras GTPase binding [Amigo]  Ras GTPase binding
GO	diacylglycerol binding [Amigo]  diacylglycerol binding
GO	regulation of GTPase activity [Amigo]  regulation of GTPase activity
GO	Rap GTPase activator activity [Amigo]  Rap GTPase activator activity
GO	regulation of small GTPase mediated signal transduction [Amigo]  regulation of small GTPase mediated signal transduction
KEGG	MAPK signaling pathway
KEGG	B cell receptor signaling pathway
PubGene	RASGRP3
TreeFam	RASGRP3
CTD	25780 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	RASGRP3 Related clones (RZPD - Berlin)
	PubMed
PubMed	17 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:08:01 2008