Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RASGRP4 (RAS guanyl releasing protein 4)

Identity

Other alias-
HGNC (Hugo) RASGRP4
LocusID (NCBI) 115727
Atlas_Id 42056
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 38409058 and ends at 38426305 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FBL (19q13.2) / RASGRP4 (19q13.2)FBL 19q13.2 / RASGRP4 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RASGRP4   18958
Cards
Entrez_Gene (NCBI)RASGRP4  115727  RAS guanyl releasing protein 4
Aliases
GeneCards (Weizmann)RASGRP4
Ensembl hg19 (Hinxton)ENSG00000171777 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171777 [Gene_View]  chr19:38409058-38426305 [Contig_View]  RASGRP4 [Vega]
ICGC DataPortalENSG00000171777
TCGA cBioPortalRASGRP4
AceView (NCBI)RASGRP4
Genatlas (Paris)RASGRP4
WikiGenes115727
SOURCE (Princeton)RASGRP4
Genetics Home Reference (NIH)RASGRP4
Genomic and cartography
GoldenPath hg38 (UCSC)RASGRP4  -     chr19:38409058-38426305 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASGRP4  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblRASGRP4 - 19q13.2 [CytoView hg19]  RASGRP4 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIRASGRP4 [Mapview hg19]  RASGRP4 [Mapview hg38]
OMIM607320   
Gene and transcription
Genbank (Entrez)AF448437 AK097292 AY048119 AY048120 AY048121
RefSeq transcript (Entrez)NM_001146202 NM_001146203 NM_001146204 NM_001146205 NM_001146206 NM_001146207 NM_052949 NM_170602 NM_170603 NM_170604
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RASGRP4
Cluster EST : UnigeneHs.130434 [ NCBI ]
CGAP (NCI)Hs.130434
Alternative Splicing GalleryENSG00000171777
Gene ExpressionRASGRP4 [ NCBI-GEO ]   RASGRP4 [ EBI - ARRAY_EXPRESS ]   RASGRP4 [ SEEK ]   RASGRP4 [ MEM ]
Gene Expression Viewer (FireBrowse)RASGRP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115727
GTEX Portal (Tissue expression)RASGRP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDF6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDF6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDF6
Splice isoforms : SwissVarQ8TDF6
PhosPhoSitePlusQ8TDF6
Domaine pattern : Prosite (Expaxy)EF_HAND_2 (PS50222)    RASGEF_CAT (PS50009)    RASGEF_NTER (PS50212)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    EF_hand_dom    PE/DAG-bd    Ras-like_Gua-exchang_fac_N    Ras_GEF_dom    RASGEF_cat_dom   
Domain families : Pfam (Sanger)C1_1 (PF00130)    RasGEF (PF00617)   
Domain families : Pfam (NCBI)pfam00130    pfam00617   
Domain families : Smart (EMBL)C1 (SM00109)  RasGEF (SM00147)  
Conserved Domain (NCBI)RASGRP4
DMDM Disease mutations115727
Blocks (Seattle)RASGRP4
SuperfamilyQ8TDF6
Human Protein AtlasENSG00000171777
Peptide AtlasQ8TDF6
HPRD09540
IPIIPI00291367   IPI00479608   IPI00929556   IPI00929404   IPI00929689   IPI00929159   IPI00929541   IPI00929227   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDF6
IntAct (EBI)Q8TDF6
FunCoupENSG00000171777
BioGRIDRASGRP4
STRING (EMBL)RASGRP4
ZODIACRASGRP4
Ontologies - Pathways
QuickGOQ8TDF6
Ontology : AmiGOMAPK cascade  Ras guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  activation of phospholipase C activity  small GTPase mediated signal transduction  regulation of G-protein coupled receptor protein signaling pathway  cell proliferation  response to extracellular stimulus  membrane  cell growth  diacylglycerol binding  myeloid cell differentiation  GTP-dependent protein binding  positive regulation of GTPase activity  positive regulation of Ras protein signal transduction  
Ontology : EGO-EBIMAPK cascade  Ras guanyl-nucleotide exchange factor activity  Ras guanyl-nucleotide exchange factor activity  calcium ion binding  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  activation of phospholipase C activity  small GTPase mediated signal transduction  regulation of G-protein coupled receptor protein signaling pathway  cell proliferation  response to extracellular stimulus  membrane  cell growth  diacylglycerol binding  myeloid cell differentiation  GTP-dependent protein binding  positive regulation of GTPase activity  positive regulation of Ras protein signal transduction  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway   
NDEx NetworkRASGRP4
Atlas of Cancer Signalling NetworkRASGRP4
Wikipedia pathwaysRASGRP4
Orthology - Evolution
OrthoDB115727
GeneTree (enSembl)ENSG00000171777
Phylogenetic Trees/Animal Genes : TreeFamRASGRP4
HOVERGENQ8TDF6
HOGENOMQ8TDF6
Homologs : HomoloGeneRASGRP4
Homology/Alignments : Family Browser (UCSC)RASGRP4
Gene fusions - Rearrangements
Fusion : MitelmanFBL/RASGRP4 [19q13.2/19q13.2]  [t(19;19)(q13;q13)]  
Fusion: TCGAFBL 19q13.2 RASGRP4 19q13.2 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASGRP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASGRP4
dbVarRASGRP4
ClinVarRASGRP4
1000_GenomesRASGRP4 
Exome Variant ServerRASGRP4
ExAC (Exome Aggregation Consortium)RASGRP4 (select the gene name)
Genetic variants : HAPMAP115727
Genomic Variants (DGV)RASGRP4 [DGVbeta]
DECIPHERRASGRP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASGRP4 
Mutations
ICGC Data PortalRASGRP4 
TCGA Data PortalRASGRP4 
Broad Tumor PortalRASGRP4
OASIS PortalRASGRP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASGRP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASGRP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASGRP4
DgiDB (Drug Gene Interaction Database)RASGRP4
DoCM (Curated mutations)RASGRP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASGRP4 (select a term)
intoGenRASGRP4
Cancer3DRASGRP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607320   
Orphanet
MedgenRASGRP4
Genetic Testing Registry RASGRP4
NextProtQ8TDF6 [Medical]
TSGene115727
GENETestsRASGRP4
Target ValidationRASGRP4
Huge Navigator RASGRP4 [HugePedia]
snp3D : Map Gene to Disease115727
BioCentury BCIQRASGRP4
ClinGenRASGRP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115727
Chemical/Pharm GKB GenePA38770
Clinical trialRASGRP4
Miscellaneous
canSAR (ICR)RASGRP4 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASGRP4
EVEXRASGRP4
GoPubMedRASGRP4
iHOPRASGRP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:28:10 CEST 2017

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