RASSF1 (Ras association (RalGDS/AF-6) domain family member)

Alias (NCBI)	123F2
	RDA32
	REH3P21
HGNC (Hugo)	RASSF1
HGNC Alias symb	NORE2A
	REH3P21
	RDA32
	123F2
HGNC Previous name	Ras association (RalGDS/AF-6) domain family member 1
LocusID (NCBI)	11186
Atlas_Id	377
Location	3p21.31  [Link to chromosome band 3p21]
Location_base_pair	Starts at 50329788 and ends at 50340836 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping RASSF1.png]
Local_order	telomeric to BLU and centromeric to FUS1
	Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics

	Grey: exon 1a, green: exon 1b; blue: exon 2ab; yellow : exon 2g; brown: exons 3,4, 5, 6. Arrows: transcription start sites. CpG: location of CpG islands. RASSF1A and RASSF1B start with exon 1a and 1b respectively. The second exon (2ab) is common to both forms. Exon 2g is the first exon of RASSF1C and is present in this transcript only.
Description	the genomic size of the gene is about 7.6 kb.
Transcription	At least three alternative transcripts were identified (A, B and C) that originate from alternative splicing and promoter usage. Exons 3 to 6 are common to all forms. Transcript A has two 5' exons (designated 1a and 2ab), this cDNA is 1,873 bp (ORF: 340 amino acids). RASSF1B first exon is designated 1b and is different from RASSF1A. Exon two is 2ab as in transcript A. cDNA size: 1,664 bp. Transcript RASSF1C first exon is designated 2g, cDNA size 1700 bp (ORF 270 amino acids).
Pseudogene	no known pseudogenes.

	Schematic representation of RASSF1 protein variants, as deduced from the transcripts.
Description	The carboxy terminus of RASSF1A shows about 55% identity to the mouse protein Nore1 and the rat protein Maxp1, both are Ras effector proteins (Nore1 was shown to interact in vivo with Ras upon receptor activation in a GTP-dependent manner). RASSF1A N terminus has high homology with a domain known as protein kinase C conserved region 1 domain (a cysteine-rich diacylglycerol/phorbol ester binding domain). RASSF1B most likely is constituted only of the Ras association domain.
Expression	RASSF1A and RASSF1C are expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, small intestine, colon, peripheral blood leukocytes. RASSF1B is expressed predominantly in cells of hematopoietic origin.
Localisation	not determined.
Function	RASSF1 binds Ras in a GTP-dependent manner and may serve as the effector that mediates Ras apoptotic effects. Alternatively, it may sequester RAS proteins thereby regulating the availability of these proteins for signaling.

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