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RASSF3 (Ras association domain family member 3)

Identity

Alias_namesRas association (RalGDS/AF-6) domain family member 3
Other aliasRASSF5
HGNC (Hugo) RASSF3
LocusID (NCBI) 283349
Atlas_Id 42057
Location 12q14.2  [Link to chromosome band 12q14]
Location_base_pair Starts at 64610513 and ends at 64697567 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARRB1 (11q13.4) / RASSF3 (12q14.2)EPS15 (1p32.3) / RASSF3 (12q14.2)FAM135A (6q13) / RASSF3 (12q14.2)
FRS2 (12q15) / RASSF3 (12q14.2)ITPR2 (12p12.1) / RASSF3 (12q14.2)METTL21B (12q14.1) / RASSF3 (12q14.2)
RASSF3 (12q14.2) / PPP3CA (4q24)RASSF3 (12q14.2) / SNX10 (7p15.2)RASSF3 (12q14.2) / SOS2 (14q21.3)
RASSF3 (12q14.2) / TTYH2 (17q25.1)SLC30A6 (2p22.3) / RASSF3 (12q14.2)ARRB1 11q13.4 / RASSF3 12q14.2
FRS2 12q15 / RASSF3 12q14.2ITPR2 12p12.1 / RASSF3 12q14.2METTL21B 12q14.1 / RASSF3 12q14.2
RASSF3 12q14.2 / PPP3CA 4q24RASSF3 12q14.2 / SNX10 7p15.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)RASSF3   14271
Cards
Entrez_Gene (NCBI)RASSF3  283349  Ras association domain family member 3
AliasesRASSF5
GeneCards (Weizmann)RASSF3
Ensembl hg19 (Hinxton)ENSG00000153179 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153179 [Gene_View]  chr12:64610513-64697567 [Contig_View]  RASSF3 [Vega]
ICGC DataPortalENSG00000153179
TCGA cBioPortalRASSF3
AceView (NCBI)RASSF3
Genatlas (Paris)RASSF3
WikiGenes283349
SOURCE (Princeton)RASSF3
Genetics Home Reference (NIH)RASSF3
Genomic and cartography
GoldenPath hg38 (UCSC)RASSF3  -     chr12:64610513-64697567 +  12q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASSF3  -     12q14.2   [Description]    (hg19-Feb_2009)
EnsemblRASSF3 - 12q14.2 [CytoView hg19]  RASSF3 - 12q14.2 [CytoView hg38]
Mapping of homologs : NCBIRASSF3 [Mapview hg19]  RASSF3 [Mapview hg38]
OMIM607019   
Gene and transcription
Genbank (Entrez)AA425154 AY217662 AY217663 BC100949 BC100950
RefSeq transcript (Entrez)NM_178169
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RASSF3
Cluster EST : UnigeneHs.643605 [ NCBI ]
CGAP (NCI)Hs.643605
Alternative Splicing GalleryENSG00000153179
Gene ExpressionRASSF3 [ NCBI-GEO ]   RASSF3 [ EBI - ARRAY_EXPRESS ]   RASSF3 [ SEEK ]   RASSF3 [ MEM ]
Gene Expression Viewer (FireBrowse)RASSF3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283349
GTEX Portal (Tissue expression)RASSF3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WH2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WH2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WH2
Splice isoforms : SwissVarQ86WH2
PhosPhoSitePlusQ86WH2
Domaine pattern : Prosite (Expaxy)RA (PS50200)    SARAH (PS50951)   
Domains : Interpro (EBI)C-RASSF    RA_dom    RASSF3    SARAH_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)Nore1-SARAH (PF16517)    RA (PF00788)   
Domain families : Pfam (NCBI)pfam16517    pfam00788   
Domain families : Smart (EMBL)RA (SM00314)  
Conserved Domain (NCBI)RASSF3
DMDM Disease mutations283349
Blocks (Seattle)RASSF3
SuperfamilyQ86WH2
Human Protein AtlasENSG00000153179
Peptide AtlasQ86WH2
HPRD08448
IPIIPI00176829   IPI00384453   IPI01011498   
Protein Interaction databases
DIP (DOE-UCLA)Q86WH2
IntAct (EBI)Q86WH2
FunCoupENSG00000153179
BioGRIDRASSF3
STRING (EMBL)RASSF3
ZODIACRASSF3
Ontologies - Pathways
QuickGOQ86WH2
Ontology : AmiGOprotein binding  cytosol  microtubule  plasma membrane  signal transduction  identical protein binding  regulation of apoptotic process  
Ontology : EGO-EBIprotein binding  cytosol  microtubule  plasma membrane  signal transduction  identical protein binding  regulation of apoptotic process  
NDEx NetworkRASSF3
Atlas of Cancer Signalling NetworkRASSF3
Wikipedia pathwaysRASSF3
Orthology - Evolution
OrthoDB283349
GeneTree (enSembl)ENSG00000153179
Phylogenetic Trees/Animal Genes : TreeFamRASSF3
HOVERGENQ86WH2
HOGENOMQ86WH2
Homologs : HomoloGeneRASSF3
Homology/Alignments : Family Browser (UCSC)RASSF3
Gene fusions - Rearrangements
Fusion : MitelmanARRB1/RASSF3 [11q13.4/12q14.2]  [t(11;12)(q13;q14)]  
Fusion : MitelmanFRS2/RASSF3 [12q15/12q14.2]  [t(12;12)(q14;q15)]  
Fusion : MitelmanITPR2/RASSF3 [12p12.1/12q14.2]  [t(12;12)(p11;q14)]  
Fusion : MitelmanMETTL21B/RASSF3 [12q14.1/12q14.2]  [t(12;12)(q14;q14)]  
Fusion : MitelmanRASSF3/PPP3CA [12q14.2/4q24]  [t(4;12)(q24;q14)]  
Fusion : MitelmanRASSF3/SNX10 [12q14.2/7p15.2]  [t(7;12)(p15;q14)]  
Fusion : MitelmanRASSF3/TTYH2 [12q14.2/17q25.1]  [t(12;17)(q14;q25)]  
Fusion: TCGAARRB1 11q13.4 RASSF3 12q14.2 BRCA
Fusion: TCGAFRS2 12q15 RASSF3 12q14.2 PRAD
Fusion: TCGAITPR2 12p12.1 RASSF3 12q14.2 LUAD
Fusion: TCGAMETTL21B 12q14.1 RASSF3 12q14.2 LUSC
Fusion: TCGARASSF3 12q14.2 PPP3CA 4q24 PRAD
Fusion: TCGARASSF3 12q14.2 SNX10 7p15.2 LGG
Fusion Cancer (Beijing)FAM135A [6q13]  -  RASSF3 [12q14.2]  [FUSC002371]  [FUSC002371]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASSF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASSF3
dbVarRASSF3
ClinVarRASSF3
1000_GenomesRASSF3 
Exome Variant ServerRASSF3
ExAC (Exome Aggregation Consortium)RASSF3 (select the gene name)
Genetic variants : HAPMAP283349
Genomic Variants (DGV)RASSF3 [DGVbeta]
DECIPHERRASSF3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASSF3 
Mutations
ICGC Data PortalRASSF3 
TCGA Data PortalRASSF3 
Broad Tumor PortalRASSF3
OASIS PortalRASSF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASSF3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASSF3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASSF3
DgiDB (Drug Gene Interaction Database)RASSF3
DoCM (Curated mutations)RASSF3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASSF3 (select a term)
intoGenRASSF3
Cancer3DRASSF3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607019   
Orphanet
MedgenRASSF3
Genetic Testing Registry RASSF3
NextProtQ86WH2 [Medical]
TSGene283349
GENETestsRASSF3
Huge Navigator RASSF3 [HugePedia]
snp3D : Map Gene to Disease283349
BioCentury BCIQRASSF3
ClinGenRASSF3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD283349
Chemical/Pharm GKB GenePA34247
Clinical trialRASSF3
Miscellaneous
canSAR (ICR)RASSF3 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASSF3
EVEXRASSF3
GoPubMedRASSF3
iHOPRASSF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:34:23 CEST 2017

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