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RASSF4 (Ras association domain family member 4)

Identity

Alias_namesRas association (RalGDS/AF-6) domain family member 4
Alias_symbol (synonym)AD037
MGC44914
Other alias
HGNC (Hugo) RASSF4
LocusID (NCBI) 83937
Atlas_Id 42058
Location 10q11.21  [Link to chromosome band 10q11]
Location_base_pair Starts at 44959771 and ends at 44994724 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APBB3 (5q31.3) / RASSF4 (10q11.21)FCGRT (19q13.33) / RASSF4 (10q11.21)NMRAL1 (16p13.3) / RASSF4 (10q11.21)
RASSF4 (10q11.21) / BPGM (7q33)RASSF4 (10q11.21) / DDB1 (11q12.2)RASSF4 (10q11.21) / DES (2q35)
RASSF4 (10q11.21) / RASSF4 (10q11.21)RASSF4 (10q11.21) / RFC3 (13q13.2)RASSF4 (10q11.21) / TMEM72 (10q11.21)
RASSF4 (10q11.21) / ZNF22 (10q11.21)RASSF4 10q11.21 / TMEM72 10q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q11;q11) RASSF4/TMEM72

External links

Nomenclature
HGNC (Hugo)RASSF4   20793
Cards
Entrez_Gene (NCBI)RASSF4  83937  Ras association domain family member 4
AliasesAD037
GeneCards (Weizmann)RASSF4
Ensembl hg19 (Hinxton)ENSG00000107551 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107551 [Gene_View]  chr10:44959771-44994724 [Contig_View]  RASSF4 [Vega]
ICGC DataPortalENSG00000107551
TCGA cBioPortalRASSF4
AceView (NCBI)RASSF4
Genatlas (Paris)RASSF4
WikiGenes83937
SOURCE (Princeton)RASSF4
Genetics Home Reference (NIH)RASSF4
Genomic and cartography
GoldenPath hg38 (UCSC)RASSF4  -     chr10:44959771-44994724 +  10q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RASSF4  -     10q11.21   [Description]    (hg19-Feb_2009)
EnsemblRASSF4 - 10q11.21 [CytoView hg19]  RASSF4 - 10q11.21 [CytoView hg38]
Mapping of homologs : NCBIRASSF4 [Mapview hg19]  RASSF4 [Mapview hg38]
OMIM610559   
Gene and transcription
Genbank (Entrez)AB209446 AF260335 AK055763 AK092770 AK097272
RefSeq transcript (Entrez)NM_032023 NM_178145
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RASSF4
Cluster EST : UnigeneHs.522895 [ NCBI ]
CGAP (NCI)Hs.522895
Alternative Splicing GalleryENSG00000107551
Gene ExpressionRASSF4 [ NCBI-GEO ]   RASSF4 [ EBI - ARRAY_EXPRESS ]   RASSF4 [ SEEK ]   RASSF4 [ MEM ]
Gene Expression Viewer (FireBrowse)RASSF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83937
GTEX Portal (Tissue expression)RASSF4
Human Protein AtlasENSG00000107551-RASSF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2L5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2L5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2L5
Splice isoforms : SwissVarQ9H2L5
PhosPhoSitePlusQ9H2L5
Domaine pattern : Prosite (Expaxy)RA (PS50200)    SARAH (PS50951)   
Domains : Interpro (EBI)C-RASSF    RA_dom    RASSF4    SARAH_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)Nore1-SARAH (PF16517)    RA (PF00788)   
Domain families : Pfam (NCBI)pfam16517    pfam00788   
Domain families : Smart (EMBL)RA (SM00314)  
Conserved Domain (NCBI)RASSF4
DMDM Disease mutations83937
Blocks (Seattle)RASSF4
SuperfamilyQ9H2L5
Human Protein Atlas [tissue]ENSG00000107551-RASSF4 [tissue]
Peptide AtlasQ9H2L5
HPRD15219
IPIIPI00644261   IPI00386527   IPI00760676   IPI00514251   IPI00556360   IPI00739669   IPI00514092   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2L5
IntAct (EBI)Q9H2L5
FunCoupENSG00000107551
BioGRIDRASSF4
STRING (EMBL)RASSF4
ZODIACRASSF4
Ontologies - Pathways
QuickGOQ9H2L5
Ontology : AmiGOprotein binding  cell cycle  signal transduction  
Ontology : EGO-EBIprotein binding  cell cycle  signal transduction  
NDEx NetworkRASSF4
Atlas of Cancer Signalling NetworkRASSF4
Wikipedia pathwaysRASSF4
Orthology - Evolution
OrthoDB83937
GeneTree (enSembl)ENSG00000107551
Phylogenetic Trees/Animal Genes : TreeFamRASSF4
HOVERGENQ9H2L5
HOGENOMQ9H2L5
Homologs : HomoloGeneRASSF4
Homology/Alignments : Family Browser (UCSC)RASSF4
Gene fusions - Rearrangements
Fusion : MitelmanRASSF4/TMEM72 [10q11.21/10q11.21]  
Fusion: TCGA_MDACCRASSF4 10q11.21 TMEM72 10q11.21 BRCA
Fusion PortalRASSF4 10q11.21 TMEM72 10q11.21 BRCA
Fusion : QuiverRASSF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRASSF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RASSF4
dbVarRASSF4
ClinVarRASSF4
1000_GenomesRASSF4 
Exome Variant ServerRASSF4
ExAC (Exome Aggregation Consortium)ENSG00000107551
GNOMAD BrowserENSG00000107551
Genetic variants : HAPMAP83937
Genomic Variants (DGV)RASSF4 [DGVbeta]
DECIPHERRASSF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRASSF4 
Mutations
ICGC Data PortalRASSF4 
TCGA Data PortalRASSF4 
Broad Tumor PortalRASSF4
OASIS PortalRASSF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRASSF4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRASSF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RASSF4
DgiDB (Drug Gene Interaction Database)RASSF4
DoCM (Curated mutations)RASSF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RASSF4 (select a term)
intoGenRASSF4
Cancer3DRASSF4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610559   
Orphanet
DisGeNETRASSF4
MedgenRASSF4
Genetic Testing Registry RASSF4
NextProtQ9H2L5 [Medical]
TSGene83937
GENETestsRASSF4
Target ValidationRASSF4
Huge Navigator RASSF4 [HugePedia]
snp3D : Map Gene to Disease83937
BioCentury BCIQRASSF4
ClinGenRASSF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83937
Chemical/Pharm GKB GenePA134951366
Clinical trialRASSF4
Miscellaneous
canSAR (ICR)RASSF4 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRASSF4
EVEXRASSF4
GoPubMedRASSF4
iHOPRASSF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:34:14 CET 2018
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