RB1CC1 (RB1 inducible coiled-coil 1)

2003-02-01  

Identity

HGNC
LOCATION
8q11.23
LOCUSID
ALIAS
ATG17,CC1,FIP200,PPP1R131
FUSION GENES

Other Information

Locus ID:

NCBI: 9821
MIM: 606837
HGNC: 15574
Ensembl: ENSG00000023287

Variants:

dbSNP: 9821
ClinVar: 9821
TCGA: ENSG00000023287
COSMIC: RB1CC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000023287ENST00000025008Q8TDY2
ENSG00000023287ENST00000435644Q8TDY2
ENSG00000023287ENST00000517963E5RH44
ENSG00000023287ENST00000518211E5RJC1
ENSG00000023287ENST00000518468E5RHX0
ENSG00000023287ENST00000518710E5RH63
ENSG00000023287ENST00000519912H0YC30
ENSG00000023287ENST00000523594H0YC28

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192251512009ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.679
192583182009ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.479
184432212008FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.373
196903282009mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex.88
232624922013Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.79
217758232011p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.57
160435122005Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control.40
120682962002Truncating mutations of RB1CC1 in human breast cancer.36
180367792008FIP200, a key signaling node to coordinately regulate various cellular processes.36
160616482005Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.35

Citation

Dessen P

RB1CC1 (RB1 inducible coiled-coil 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42060/rb1cc1