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RBBP4 (RB binding protein 4, chromatin remodeling factor)

Identity

Alias (NCBI)NURF55
RBAP48
lin-53
HGNC (Hugo) RBBP4
HGNC Alias symbRbAp48
NURF55
lin-53
HGNC Previous nameretinoblastoma-binding protein 4
 retinoblastoma binding protein 4
LocusID (NCBI) 5928
Atlas_Id 42062
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 32651208 and ends at 32686211 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELN (7q11.23) / RBBP4 (1p35.1)RBBP4 (1p35.1) / NEAT1 (11q13.1)RBBP4 (1p35.1) / RBBP4 (1p35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)RBBP4   9887
Cards
Entrez_Gene (NCBI)RBBP4  5928  RB binding protein 4, chromatin remodeling factor
AliasesNURF55; RBAP48; lin-53
GeneCards (Weizmann)RBBP4
Ensembl hg19 (Hinxton)ENSG00000162521 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162521 [Gene_View]  ENSG00000162521 [Sequence]  chr1:32651208-32686211 [Contig_View]  RBBP4 [Vega]
ICGC DataPortalENSG00000162521
TCGA cBioPortalRBBP4
AceView (NCBI)RBBP4
Genatlas (Paris)RBBP4
WikiGenes5928
SOURCE (Princeton)RBBP4
Genetics Home Reference (NIH)RBBP4
Genomic and cartography
GoldenPath hg38 (UCSC)RBBP4  -     chr1:32651208-32686211 +  1p35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RBBP4  -     1p35.1   [Description]    (hg19-Feb_2009)
GoldenPathRBBP4 - 1p35.1 [CytoView hg19]  RBBP4 - 1p35.1 [CytoView hg38]
ImmunoBaseENSG00000162521
genome Data Viewer NCBIRBBP4 [Mapview hg19]  
OMIM602923   
Gene and transcription
Genbank (Entrez)AK056356 AK056550 AK222779 AK299251 AK299410
RefSeq transcript (Entrez)NM_001135255 NM_001135256 NM_005610
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RBBP4
Alternative Splicing GalleryENSG00000162521
Gene ExpressionRBBP4 [ NCBI-GEO ]   RBBP4 [ EBI - ARRAY_EXPRESS ]   RBBP4 [ SEEK ]   RBBP4 [ MEM ]
Gene Expression Viewer (FireBrowse)RBBP4 [ Firebrowse - Broad ]
GenevisibleExpression of RBBP4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5928
GTEX Portal (Tissue expression)RBBP4
Human Protein AtlasENSG00000162521-RBBP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ09028   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ09028  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ09028
Splice isoforms : SwissVarQ09028
PhosPhoSitePlusQ09028
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Histone-bd_RBBP4_N    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)CAF1C_H4-bd (PF12265)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12265    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)RBBP4
DMDM Disease mutations5928
Blocks (Seattle)RBBP4
PDB (RSDB)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A    5FXY    5VTB    5WAI    5WAK    5XWR    5XXQ    5Y1U    6BW3    6BW4    6C23    6C24    6G16   
PDB Europe2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A    5FXY    5VTB    5WAI    5WAK    5XWR    5XXQ    5Y1U    6BW3    6BW4    6C23    6C24    6G16   
PDB (PDBSum)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A    5FXY    5VTB    5WAI    5WAK    5XWR    5XXQ    5Y1U    6BW3    6BW4    6C23    6C24    6G16   
PDB (IMB)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A    5FXY    5VTB    5WAI    5WAK    5XWR    5XXQ    5Y1U    6BW3    6BW4    6C23    6C24    6G16   
Structural Biology KnowledgeBase2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A    5FXY    5VTB    5WAI    5WAK    5XWR    5XXQ    5Y1U    6BW3    6BW4    6C23    6C24    6G16   
SCOP (Structural Classification of Proteins)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A    5FXY    5VTB    5WAI    5WAK    5XWR    5XXQ    5Y1U    6BW3    6BW4    6C23    6C24    6G16   
CATH (Classification of proteins structures)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A    5FXY    5VTB    5WAI    5WAK    5XWR    5XXQ    5Y1U    6BW3    6BW4    6C23    6C24    6G16   
SuperfamilyQ09028
Human Protein Atlas [tissue]ENSG00000162521-RBBP4 [tissue]
Peptide AtlasQ09028
HPRD04232
IPIIPI00328319   IPI00877934   IPI00645329   IPI00877802   IPI00983362   IPI00974561   IPI00977081   IPI00977160   IPI01011643   IPI00979287   IPI00980511   IPI00976513   IPI00976614   
Protein Interaction databases
DIP (DOE-UCLA)Q09028
IntAct (EBI)Q09028
FunCoupENSG00000162521
BioGRIDRBBP4
STRING (EMBL)RBBP4
ZODIACRBBP4
Ontologies - Pathways
QuickGOQ09028
Ontology : AmiGOnuclear chromatin  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  DNA replication  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  chromatin remodeling  cell cycle  DNA-dependent ATPase activity  negative regulation of cell proliferation  Sin3 complex  NuRD complex  NuRD complex  NURF complex  nucleosomal DNA binding  chromatin assembly  protein-containing complex  protein-containing complex  CAF-1 complex  CENP-A containing nucleosome assembly  ESC/E(Z) complex  histone binding  histone deacetylase binding  ATP-dependent chromatin remodeling  negative regulation of gene expression, epigenetic  regulation of cell cycle  response to growth hormone  negative regulation of G0 to G1 transition  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBInuclear chromatin  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  DNA replication  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  chromatin remodeling  cell cycle  DNA-dependent ATPase activity  negative regulation of cell proliferation  Sin3 complex  NuRD complex  NuRD complex  NURF complex  nucleosomal DNA binding  chromatin assembly  protein-containing complex  protein-containing complex  CAF-1 complex  CENP-A containing nucleosome assembly  ESC/E(Z) complex  histone binding  histone deacetylase binding  ATP-dependent chromatin remodeling  negative regulation of gene expression, epigenetic  regulation of cell cycle  response to growth hormone  negative regulation of G0 to G1 transition  regulation of signal transduction by p53 class mediator  
NDEx NetworkRBBP4
Atlas of Cancer Signalling NetworkRBBP4
Wikipedia pathwaysRBBP4
Orthology - Evolution
OrthoDB5928
GeneTree (enSembl)ENSG00000162521
Phylogenetic Trees/Animal Genes : TreeFamRBBP4
HOGENOMQ09028
Homologs : HomoloGeneRBBP4
Homology/Alignments : Family Browser (UCSC)RBBP4
Gene fusions - Rearrangements
Fusion : QuiverRBBP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRBBP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RBBP4
dbVarRBBP4
ClinVarRBBP4
MonarchRBBP4
1000_GenomesRBBP4 
Exome Variant ServerRBBP4
GNOMAD BrowserENSG00000162521
Varsome BrowserRBBP4
Genetic variants : HAPMAP5928
Genomic Variants (DGV)RBBP4 [DGVbeta]
DECIPHERRBBP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRBBP4 
Mutations
ICGC Data PortalRBBP4 
TCGA Data PortalRBBP4 
Broad Tumor PortalRBBP4
OASIS PortalRBBP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRBBP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRBBP4
Mutations and Diseases : HGMDRBBP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RBBP4
DgiDB (Drug Gene Interaction Database)RBBP4
DoCM (Curated mutations)RBBP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RBBP4 (select a term)
intoGenRBBP4
Cancer3DRBBP4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602923   
Orphanet
DisGeNETRBBP4
MedgenRBBP4
Genetic Testing Registry RBBP4
NextProtQ09028 [Medical]
TSGene5928
GENETestsRBBP4
Target ValidationRBBP4
Huge Navigator RBBP4 [HugePedia]
snp3D : Map Gene to Disease5928
BioCentury BCIQRBBP4
ClinGenRBBP4
Clinical trials, drugs, therapy
Protein Interactions : CTD5928
Pharm GKB GenePA34251
Clinical trialRBBP4
Miscellaneous
canSAR (ICR)RBBP4 (select the gene name)
HarmonizomeRBBP4
DataMed IndexRBBP4
Probes
Litterature
PubMed278 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRBBP4
EVEXRBBP4
GoPubMedRBBP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:29:45 CEST 2020

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