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RBBP4 (retinoblastoma binding protein 4)

Identity

Alias_namesretinoblastoma-binding protein 4
retinoblastoma binding protein 4
Alias_symbol (synonym)RbAp48
NURF55
lin-53
Other aliasRBAP48
HGNC (Hugo) RBBP4
LocusID (NCBI) 5928
Atlas_Id 42062
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 33116749 and ends at 33151812 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ELN (7q11.23) / RBBP4 (1p35.1)RBBP4 (1p35.1) / NEAT1 (11q13.1)RBBP4 (1p35.1) / RBBP4 (1p35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RBBP4   9887
Cards
Entrez_Gene (NCBI)RBBP4  5928  retinoblastoma binding protein 4
AliasesNURF55; RBAP48; lin-53
GeneCards (Weizmann)RBBP4
Ensembl hg19 (Hinxton)ENSG00000162521 [Gene_View]  chr1:33116749-33151812 [Contig_View]  RBBP4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000162521 [Gene_View]  chr1:33116749-33151812 [Contig_View]  RBBP4 [Vega]
ICGC DataPortalENSG00000162521
TCGA cBioPortalRBBP4
AceView (NCBI)RBBP4
Genatlas (Paris)RBBP4
WikiGenes5928
SOURCE (Princeton)RBBP4
Genetics Home Reference (NIH)RBBP4
Genomic and cartography
GoldenPath hg19 (UCSC)RBBP4  -     chr1:33116749-33151812 +  1p35.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RBBP4  -     1p35.1   [Description]    (hg38-Dec_2013)
EnsemblRBBP4 - 1p35.1 [CytoView hg19]  RBBP4 - 1p35.1 [CytoView hg38]
Mapping of homologs : NCBIRBBP4 [Mapview hg19]  RBBP4 [Mapview hg38]
OMIM602923   
Gene and transcription
Genbank (Entrez)AK056356 AK056550 AK222779 AK299251 AK299410
RefSeq transcript (Entrez)NM_001135255 NM_001135256 NM_005610
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)RBBP4
Cluster EST : UnigeneHs.16003 [ NCBI ]
CGAP (NCI)Hs.16003
Alternative Splicing GalleryENSG00000162521
Gene ExpressionRBBP4 [ NCBI-GEO ]   RBBP4 [ EBI - ARRAY_EXPRESS ]   RBBP4 [ SEEK ]   RBBP4 [ MEM ]
Gene Expression Viewer (FireBrowse)RBBP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5928
GTEX Portal (Tissue expression)RBBP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ09028   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ09028  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ09028
Splice isoforms : SwissVarQ09028
PhosPhoSitePlusQ09028
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Histone-bd_RBBP4_N    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)CAF1C_H4-bd (PF12265)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12265    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)RBBP4
DMDM Disease mutations5928
Blocks (Seattle)RBBP4
PDB (SRS)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A   
PDB (PDBSum)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A   
PDB (IMB)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A   
PDB (RSDB)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A   
Structural Biology KnowledgeBase2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A   
SCOP (Structural Classification of Proteins)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A   
CATH (Classification of proteins structures)2XU7    3GFC    4PBY    4PBZ    4PC0    4R7A   
SuperfamilyQ09028
Human Protein AtlasENSG00000162521
Peptide AtlasQ09028
HPRD04232
IPIIPI00328319   IPI00877934   IPI00645329   IPI00877802   IPI00983362   IPI00974561   IPI00977081   IPI00977160   IPI01011643   IPI00979287   IPI00980511   IPI00976513   IPI00976614   
Protein Interaction databases
DIP (DOE-UCLA)Q09028
IntAct (EBI)Q09028
FunCoupENSG00000162521
BioGRIDRBBP4
STRING (EMBL)RBBP4
ZODIACRBBP4
Ontologies - Pathways
QuickGOQ09028
Ontology : AmiGOnuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  histone deacetylase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  chromatin remodeling  transcription, DNA-templated  regulation of transcription, DNA-templated  cell cycle  DNA-dependent ATPase activity  negative regulation of cell proliferation  histone deacetylation  Sin3 complex  NuRD complex  NuRD complex  NURF complex  nucleosomal DNA binding  chromatin assembly  CAF-1 complex  CENP-A containing nucleosome assembly  ESC/E(Z) complex  histone binding  histone deacetylase binding  ATP-dependent chromatin remodeling  protein complex  negative regulation of gene expression, epigenetic  regulation of cell cycle  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  histone deacetylase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication-dependent nucleosome assembly  DNA replication-independent nucleosome assembly  chromatin remodeling  transcription, DNA-templated  regulation of transcription, DNA-templated  cell cycle  DNA-dependent ATPase activity  negative regulation of cell proliferation  histone deacetylation  Sin3 complex  NuRD complex  NuRD complex  NURF complex  nucleosomal DNA binding  chromatin assembly  CAF-1 complex  CENP-A containing nucleosome assembly  ESC/E(Z) complex  histone binding  histone deacetylase binding  ATP-dependent chromatin remodeling  protein complex  negative regulation of gene expression, epigenetic  regulation of cell cycle  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAThe PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails [Genes]   
NDEx NetworkRBBP4
Atlas of Cancer Signalling NetworkRBBP4
Wikipedia pathwaysRBBP4
Orthology - Evolution
OrthoDB5928
GeneTree (enSembl)ENSG00000162521
Phylogenetic Trees/Animal Genes : TreeFamRBBP4
HOVERGENQ09028
HOGENOMQ09028
Homologs : HomoloGeneRBBP4
Homology/Alignments : Family Browser (UCSC)RBBP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRBBP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RBBP4
dbVarRBBP4
ClinVarRBBP4
1000_GenomesRBBP4 
Exome Variant ServerRBBP4
ExAC (Exome Aggregation Consortium)RBBP4 (select the gene name)
Genetic variants : HAPMAP5928
Genomic Variants (DGV)RBBP4 [DGVbeta]
DECIPHER (Syndromes)1:33116749-33151812  ENSG00000162521
CONAN: Copy Number AnalysisRBBP4 
Mutations
ICGC Data PortalRBBP4 
TCGA Data PortalRBBP4 
Broad Tumor PortalRBBP4
OASIS PortalRBBP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRBBP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRBBP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RBBP4
DgiDB (Drug Gene Interaction Database)RBBP4
DoCM (Curated mutations)RBBP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RBBP4 (select a term)
intoGenRBBP4
Cancer3DRBBP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602923   
Orphanet
MedgenRBBP4
Genetic Testing Registry RBBP4
NextProtQ09028 [Medical]
TSGene5928
GENETestsRBBP4
Huge Navigator RBBP4 [HugePedia]
snp3D : Map Gene to Disease5928
BioCentury BCIQRBBP4
ClinGenRBBP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5928
Chemical/Pharm GKB GenePA34251
Clinical trialRBBP4
Miscellaneous
canSAR (ICR)RBBP4 (select the gene name)
Probes
Litterature
PubMed195 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRBBP4
EVEXRBBP4
GoPubMedRBBP4
iHOPRBBP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:17:00 CEST 2017

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