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RBL1 (RB transcriptional corepressor like 1)

Identity

Alias (NCBI)CP107
PRB1
p107
HGNC (Hugo) RBL1
HGNC Alias symbp107
cp107
PRB1
HGNC Previous nameretinoblastoma-like 1
LocusID (NCBI) 5933
Atlas_Id 447
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 37003574 and ends at 37095997 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KLHL22 (22q11.21)::RBL1 (20q11.23)PISD (22q12.2)::RBL1 (20q11.23)RBL1 (20q11.23)::CPNE1 (20q11.22)
RBL1 (20q11.23)::CTNNBL1 (20q11.23)RBL1 (20q11.23)::PISD (22q12.2)RBL1 20q11.23::CPNE1 20q11.22
RBL1 20q11.23::CTNNBL1 20q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RBL1   9893
Cards
Entrez_Gene (NCBI)RBL1    RB transcriptional corepressor like 1
AliasesCP107; PRB1; p107
GeneCards (Weizmann)RBL1
Ensembl hg19 (Hinxton)ENSG00000080839 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080839 [Gene_View]  ENSG00000080839 [Sequence]  chr20:37003574-37095997 [Contig_View]  RBL1 [Vega]
ICGC DataPortalENSG00000080839
TCGA cBioPortalRBL1
AceView (NCBI)RBL1
Genatlas (Paris)RBL1
SOURCE (Princeton)RBL1
Genetics Home Reference (NIH)RBL1
Genomic and cartography
GoldenPath hg38 (UCSC)RBL1  -     chr20:37003574-37095997 -  20q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RBL1  -     20q11.23   [Description]    (hg19-Feb_2009)
GoldenPathRBL1 - 20q11.23 [CytoView hg19]  RBL1 - 20q11.23 [CytoView hg38]
ImmunoBaseENSG00000080839
Genome Data Viewer NCBIRBL1 [Mapview hg19]  
OMIM116957   
Gene and transcription
Genbank (Entrez)AK290380 AK308096 AK310870 BC032247 BQ004524
RefSeq transcript (Entrez)NM_001323281 NM_001323282 NM_002895 NM_183404
Consensus coding sequences : CCDS (NCBI)RBL1
Gene ExpressionRBL1 [ NCBI-GEO ]   RBL1 [ EBI - ARRAY_EXPRESS ]   RBL1 [ SEEK ]   RBL1 [ MEM ]
Gene Expression Viewer (FireBrowse)RBL1 [ Firebrowse - Broad ]
GenevisibleExpression of RBL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5933
GTEX Portal (Tissue expression)RBL1
Human Protein AtlasENSG00000080839-RBL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28749   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28749  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28749
PhosPhoSitePlusP28749
Domains : Interpro (EBI)Cyclin-like    Cyclin-like_sf    RB_A    RB_B    RB_C    RB_fam    RB_N    RBL1   
Domain families : Pfam (Sanger)DUF3452 (PF11934)    RB_A (PF01858)    RB_B (PF01857)   
Domain families : Pfam (NCBI)pfam11934    pfam01858    pfam01857   
Domain families : Smart (EMBL)CYCLIN (SM00385)  DUF3452 (SM01367)  RB_A (SM01368)  Rb_C (SM01369)  
Conserved Domain (NCBI)RBL1
PDB (RSDB)1H28    4YOO    4YOS    4YOZ    5TUV   
PDB Europe1H28    4YOO    4YOS    4YOZ    5TUV   
PDB (PDBSum)1H28    4YOO    4YOS    4YOZ    5TUV   
PDB (IMB)1H28    4YOO    4YOS    4YOZ    5TUV   
Structural Biology KnowledgeBase1H28    4YOO    4YOS    4YOZ    5TUV   
SCOP (Structural Classification of Proteins)1H28    4YOO    4YOS    4YOZ    5TUV   
CATH (Classification of proteins structures)1H28    4YOO    4YOS    4YOZ    5TUV   
SuperfamilyP28749
AlphaFold pdb e-kbP28749   
Human Protein Atlas [tissue]ENSG00000080839-RBL1 [tissue]
HPRD00312
Protein Interaction databases
DIP (DOE-UCLA)P28749
IntAct (EBI)P28749
BioGRIDRBL1
STRING (EMBL)RBL1
ZODIACRBL1
Ontologies - Pathways
QuickGOP28749
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  transcription regulator complex  chromatin organization  cell cycle  transcription factor binding  negative regulation of gene expression  cell differentiation  regulation of lipid kinase activity  positive regulation of transcription by RNA polymerase II  regulation of cell division  RNA polymerase II-specific DNA-binding transcription factor binding  promoter-specific chromatin binding  negative regulation of G1/S transition of mitotic cell cycle  negative regulation of cellular senescence  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  transcription regulator complex  chromatin organization  cell cycle  transcription factor binding  negative regulation of gene expression  cell differentiation  regulation of lipid kinase activity  positive regulation of transcription by RNA polymerase II  regulation of cell division  RNA polymerase II-specific DNA-binding transcription factor binding  promoter-specific chromatin binding  negative regulation of G1/S transition of mitotic cell cycle  negative regulation of cellular senescence  
Pathways : BIOCARTACyclins and Cell Cycle Regulation [Genes]    METS affect on Macrophage Differentiation [Genes]   
Pathways : KEGGCell cycle    TGF-beta signaling pathway    Viral carcinogenesis   
NDEx NetworkRBL1
Atlas of Cancer Signalling NetworkRBL1
Wikipedia pathwaysRBL1
Orthology - Evolution
OrthoDB5933
GeneTree (enSembl)ENSG00000080839
Phylogenetic Trees/Animal Genes : TreeFamRBL1
Homologs : HomoloGeneRBL1
Homology/Alignments : Family Browser (UCSC)RBL1
Gene fusions - Rearrangements
Fusion : MitelmanPISD::RBL1 [22q12.2/20q11.23]  
Fusion : MitelmanRBL1::CPNE1 [20q11.23/20q11.22]  
Fusion : MitelmanRBL1::CTNNBL1 [20q11.23/20q11.23]  
Fusion : MitelmanRBL1::PISD [20q11.23/22q12.2]  
Fusion : QuiverRBL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRBL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RBL1
dbVarRBL1
ClinVarRBL1
MonarchRBL1
1000_GenomesRBL1 
Exome Variant ServerRBL1
GNOMAD BrowserENSG00000080839
Varsome BrowserRBL1
ACMGRBL1 variants
VarityP28749
Genomic Variants (DGV)RBL1 [DGVbeta]
DECIPHERRBL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRBL1 
Mutations
ICGC Data PortalRBL1 
TCGA Data PortalRBL1 
Broad Tumor PortalRBL1
OASIS PortalRBL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRBL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRBL1
Mutations and Diseases : HGMDRBL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRBL1
DgiDB (Drug Gene Interaction Database)RBL1
DoCM (Curated mutations)RBL1
CIViC (Clinical Interpretations of Variants in Cancer)RBL1
Cancer3DRBL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116957   
Orphanet
DisGeNETRBL1
MedgenRBL1
Genetic Testing Registry RBL1
NextProtP28749 [Medical]
GENETestsRBL1
Target ValidationRBL1
Huge Navigator RBL1 [HugePedia]
ClinGenRBL1
Clinical trials, drugs, therapy
MyCancerGenomeRBL1
Protein Interactions : CTDRBL1
Pharm GKB GenePA34257
PharosP28749
Clinical trialRBL1
Miscellaneous
canSAR (ICR)RBL1
HarmonizomeRBL1
ARCHS4RBL1
DataMed IndexRBL1
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRBL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:30:41 CET 2022

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