Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RBM14 (RNA binding motif protein 14)

Identity

Alias_symbol (synonym)SIP
SYTIP1
COAA
DKFZp779J0927
Other aliasPSP2
TMEM137
HGNC (Hugo) RBM14
LocusID (NCBI) 10432
Atlas_Id 42068
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 66616582 and ends at 66629926 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C11orf80 (11q13.2) / RBM14 (11q13.2)CHGA (14q32.12) / RBM14 (11q13.2)RBM14 (11q13.2) / CCS (11q13.2)
RBM14 (11q13.2) / FGF3 (11q13.3)RBM14 (11q13.2) / MERTK (2q13)RBM14 (11q13.2) / PACS1 (11q13.1)
RBM14 (11q13.2) / RBM14 (11q13.2)RBM14 (11q13.2) / RBM4 (11q13.2)RBM14 (11q13.2) / RBM4B (11q13.2)
RBM14 (11q13.2) / SLC27A2 (15q21.2)SEPW1 (19q13.33) / RBM14 (11q13.2)TMCO3 (13q34) / RBM14 (11q13.2)
RBM14 PACS1C11orf80 11q13.2 / RBM14 11q13.2RBM14 11q13.2 / CCS 11q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Adenocarcinoma
t(2;11)(q13;q13) RBM14/MERTK
C11orf80/RBM14 (11q13)
RBM14/CCS (11q13)
RBM14/FGF3 (11q13)

External links

Nomenclature
HGNC (Hugo)RBM14   14219
Cards
Entrez_Gene (NCBI)RBM14  10432  RNA binding motif protein 14
AliasesCOAA; PSP2; SIP; SYTIP1; 
TMEM137
GeneCards (Weizmann)RBM14
Ensembl hg19 (Hinxton)ENSG00000239306 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000239306 [Gene_View]  ENSG00000239306 [Sequence]  chr11:66616582-66629926 [Contig_View]  RBM14 [Vega]
ICGC DataPortalENSG00000239306
TCGA cBioPortalRBM14
AceView (NCBI)RBM14
Genatlas (Paris)RBM14
WikiGenes10432
SOURCE (Princeton)RBM14
Genetics Home Reference (NIH)RBM14
Genomic and cartography
GoldenPath hg38 (UCSC)RBM14  -     chr11:66616582-66629926 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RBM14  -     11q13.2   [Description]    (hg19-Feb_2009)
EnsemblRBM14 - 11q13.2 [CytoView hg19]  RBM14 - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIRBM14 [Mapview hg19]  RBM14 [Mapview hg38]
OMIM612409   
Gene and transcription
Genbank (Entrez)AB209007 AF080561 AF315632 AF315633 AK021768
RefSeq transcript (Entrez)NM_001198836 NM_001198837 NM_006328 NM_032886
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RBM14
Cluster EST : UnigeneHs.533712 [ NCBI ]
CGAP (NCI)Hs.533712
Alternative Splicing GalleryENSG00000239306
Gene ExpressionRBM14 [ NCBI-GEO ]   RBM14 [ EBI - ARRAY_EXPRESS ]   RBM14 [ SEEK ]   RBM14 [ MEM ]
Gene Expression Viewer (FireBrowse)RBM14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10432
GTEX Portal (Tissue expression)RBM14
Human Protein AtlasENSG00000239306-RBM14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PK6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PK6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PK6
Splice isoforms : SwissVarQ96PK6
PhosPhoSitePlusQ96PK6
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RBM14_RRM1    RBM14_RRM2    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)RBM14
DMDM Disease mutations10432
Blocks (Seattle)RBM14
PDB (SRS)2DNP   
PDB (PDBSum)2DNP   
PDB (IMB)2DNP   
PDB (RSDB)2DNP   
Structural Biology KnowledgeBase2DNP   
SCOP (Structural Classification of Proteins)2DNP   
CATH (Classification of proteins structures)2DNP   
SuperfamilyQ96PK6
Human Protein Atlas [tissue]ENSG00000239306-RBM14 [tissue]
Peptide AtlasQ96PK6
HPRD11485
Protein Interaction databases
DIP (DOE-UCLA)Q96PK6
IntAct (EBI)Q96PK6
FunCoupENSG00000239306
BioGRIDRBM14
STRING (EMBL)RBM14
ZODIACRBM14
Ontologies - Pathways
QuickGOQ96PK6
Ontology : AmiGOregulation of alternative mRNA splicing, via spliceosome  activation of innate immune response  activation of innate immune response  transcription coregulator activity  RNA binding  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  transcription factor complex  transcription factor complex  nucleolus  cytoplasm  DNA replication  DNA repair  DNA recombination  transcription, DNA-templated  response to hormone  histone deacetylation  mediator complex  nuclear speck  nuclear speck  nuclear receptor transcription coactivator activity  nuclear receptor transcription coactivator activity  intracellular estrogen receptor signaling pathway  protein binding, bridging  glucocorticoid receptor signaling pathway  innate immune response  mRNA cis splicing, via spliceosome  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  negative regulation of centriole replication  SMAD protein signal transduction  centriole assembly  ribonucleoprotein complex  
Ontology : EGO-EBIregulation of alternative mRNA splicing, via spliceosome  activation of innate immune response  activation of innate immune response  transcription coregulator activity  RNA binding  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  transcription factor complex  transcription factor complex  nucleolus  cytoplasm  DNA replication  DNA repair  DNA recombination  transcription, DNA-templated  response to hormone  histone deacetylation  mediator complex  nuclear speck  nuclear speck  nuclear receptor transcription coactivator activity  nuclear receptor transcription coactivator activity  intracellular estrogen receptor signaling pathway  protein binding, bridging  glucocorticoid receptor signaling pathway  innate immune response  mRNA cis splicing, via spliceosome  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  negative regulation of centriole replication  SMAD protein signal transduction  centriole assembly  ribonucleoprotein complex  
NDEx NetworkRBM14
Atlas of Cancer Signalling NetworkRBM14
Wikipedia pathwaysRBM14
Orthology - Evolution
OrthoDB10432
GeneTree (enSembl)ENSG00000239306
Phylogenetic Trees/Animal Genes : TreeFamRBM14
HOVERGENQ96PK6
HOGENOMQ96PK6
Homologs : HomoloGeneRBM14
Homology/Alignments : Family Browser (UCSC)RBM14
Gene fusions - Rearrangements
Fusion : MitelmanC11orf80/RBM14 [11q13.2/11q13.2]  [t(11;11)(q13;q13)]  
Fusion : MitelmanRBM14/CCS [11q13.2/11q13.2]  [t(11;11)(q13;q13)]  
Fusion : MitelmanRBM14/FGF3 [11q13.2/11q13.3]  [t(11;11)(q13;q13)]  
Fusion : MitelmanRBM14/MERTK [11q13.2/2q13]  [t(2;11)(q13;q13)]  
Fusion PortalC11orf80 11q13.2 RBM14 11q13.2 LUAD
Fusion PortalRBM14 11q13.2 CCS 11q13.2 KIRC
Fusion : QuiverRBM14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRBM14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RBM14
dbVarRBM14
ClinVarRBM14
1000_GenomesRBM14 
Exome Variant ServerRBM14
ExAC (Exome Aggregation Consortium)ENSG00000239306
GNOMAD BrowserENSG00000239306
Varsome BrowserRBM14
Genetic variants : HAPMAP10432
Genomic Variants (DGV)RBM14 [DGVbeta]
DECIPHERRBM14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRBM14 
Mutations
ICGC Data PortalRBM14 
TCGA Data PortalRBM14 
Broad Tumor PortalRBM14
OASIS PortalRBM14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRBM14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRBM14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RBM14
DgiDB (Drug Gene Interaction Database)RBM14
DoCM (Curated mutations)RBM14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RBM14 (select a term)
intoGenRBM14
Cancer3DRBM14(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612409   
Orphanet
DisGeNETRBM14
MedgenRBM14
Genetic Testing Registry RBM14
NextProtQ96PK6 [Medical]
TSGene10432
GENETestsRBM14
Target ValidationRBM14
Huge Navigator RBM14 [HugePedia]
snp3D : Map Gene to Disease10432
BioCentury BCIQRBM14
ClinGenRBM14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10432
Chemical/Pharm GKB GenePA34263
Clinical trialRBM14
Miscellaneous
canSAR (ICR)RBM14 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRBM14
EVEXRBM14
GoPubMedRBM14
iHOPRBM14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:48:30 CEST 2018
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