Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RBM19 (RNA binding motif protein 19)

Identity

Alias (NCBI)Mrd1
HGNC (Hugo) RBM19
HGNC Alias symbDKFZp586F1023
KIAA0682
LocusID (NCBI) 9904
Atlas_Id 72516
Location 12q24.13  [Link to chromosome band 12q24]
Location_base_pair Starts at 113822054 and ends at 113966371 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RBM19 (12q24.13) / CLK2 (1q22)RBM19 (12q24.13) / HDHD3 (9q32)RBM19 (12q24.13) / HIBADH (7p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;12)(q22;q24) RBM19/CLK2

External links

Nomenclature
HGNC (Hugo)RBM19   29098
Cards
Entrez_Gene (NCBI)RBM19    RNA binding motif protein 19
AliasesMrd1
GeneCards (Weizmann)RBM19
Ensembl hg19 (Hinxton)ENSG00000122965 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122965 [Gene_View]  ENSG00000122965 [Sequence]  chr12:113822054-113966371 [Contig_View]  RBM19 [Vega]
ICGC DataPortalENSG00000122965
TCGA cBioPortalRBM19
AceView (NCBI)RBM19
Genatlas (Paris)RBM19
SOURCE (Princeton)RBM19
Genetics Home Reference (NIH)RBM19
Genomic and cartography
GoldenPath hg38 (UCSC)RBM19  -     chr12:113822054-113966371 -  12q24.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RBM19  -     12q24.13   [Description]    (hg19-Feb_2009)
GoldenPathRBM19 - 12q24.13 [CytoView hg19]  RBM19 - 12q24.13 [CytoView hg38]
ImmunoBaseENSG00000122965
genome Data Viewer NCBIRBM19 [Mapview hg19]  
OMIM616444   
Gene and transcription
Genbank (Entrez)AA594568 AB014582 AI218902 AK291444 AK314606
RefSeq transcript (Entrez)NM_001146698 NM_001146699 NM_016196
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RBM19
Alternative Splicing GalleryENSG00000122965
Gene ExpressionRBM19 [ NCBI-GEO ]   RBM19 [ EBI - ARRAY_EXPRESS ]   RBM19 [ SEEK ]   RBM19 [ MEM ]
Gene Expression Viewer (FireBrowse)RBM19 [ Firebrowse - Broad ]
GenevisibleExpression of RBM19 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9904
GTEX Portal (Tissue expression)RBM19
Human Protein AtlasENSG00000122965-RBM19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4C8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4C8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4C8
Splice isoforms : SwissVarQ9Y4C8
PhosPhoSitePlusQ9Y4C8
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RBM19_RRM3    RBM19_RRM4    RBM19_RRM5    RBM19_RRM6    RMB19_RRM1    RMB19_RRM2    RRM_dom    RRM_dom_euk   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  RRM_1 (SM00361)  
Conserved Domain (NCBI)RBM19
Blocks (Seattle)RBM19
PDB (RSDB)2DGW   
PDB Europe2DGW   
PDB (PDBSum)2DGW   
PDB (IMB)2DGW   
Structural Biology KnowledgeBase2DGW   
SCOP (Structural Classification of Proteins)2DGW   
CATH (Classification of proteins structures)2DGW   
SuperfamilyQ9Y4C8
Human Protein Atlas [tissue]ENSG00000122965-RBM19 [tissue]
Peptide AtlasQ9Y4C8
HPRD15225
IPIIPI00000686   IPI01022254   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4C8
IntAct (EBI)Q9Y4C8
BioGRIDRBM19
STRING (EMBL)RBM19
ZODIACRBM19
Ontologies - Pathways
QuickGOQ9Y4C8
Ontology : AmiGOregulation of alternative mRNA splicing, via spliceosome  RNA binding  RNA binding  nucleus  nucleoplasm  chromosome  nucleolus  nucleolus  nucleolus  cytoplasm  multicellular organism development  membrane  nuclear speck  positive regulation of embryonic development  mRNA cis splicing, via spliceosome  
Ontology : EGO-EBIregulation of alternative mRNA splicing, via spliceosome  RNA binding  RNA binding  nucleus  nucleoplasm  chromosome  nucleolus  nucleolus  nucleolus  cytoplasm  multicellular organism development  membrane  nuclear speck  positive regulation of embryonic development  mRNA cis splicing, via spliceosome  
NDEx NetworkRBM19
Atlas of Cancer Signalling NetworkRBM19
Wikipedia pathwaysRBM19
Orthology - Evolution
OrthoDB9904
GeneTree (enSembl)ENSG00000122965
Phylogenetic Trees/Animal Genes : TreeFamRBM19
HOGENOMQ9Y4C8
Homologs : HomoloGeneRBM19
Homology/Alignments : Family Browser (UCSC)RBM19
Gene fusions - Rearrangements
Fusion : QuiverRBM19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRBM19 [hg38]
dbVarRBM19
ClinVarRBM19
MonarchRBM19
1000_GenomesRBM19 
Exome Variant ServerRBM19
GNOMAD BrowserENSG00000122965
Varsome BrowserRBM19
Genomic Variants (DGV)RBM19 [DGVbeta]
DECIPHERRBM19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRBM19 
Mutations
ICGC Data PortalRBM19 
TCGA Data PortalRBM19 
Broad Tumor PortalRBM19
OASIS PortalRBM19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRBM19  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRBM19
Mutations and Diseases : HGMDRBM19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RBM19
DgiDB (Drug Gene Interaction Database)RBM19
DoCM (Curated mutations)RBM19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RBM19 (select a term)
intoGenRBM19
Cancer3DRBM19(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616444   
Orphanet
DisGeNETRBM19
MedgenRBM19
Genetic Testing Registry RBM19
NextProtQ9Y4C8 [Medical]
GENETestsRBM19
Target ValidationRBM19
Huge Navigator RBM19 [HugePedia]
ClinGenRBM19
Clinical trials, drugs, therapy
MyCancerGenomeRBM19
Protein Interactions : CTD
Pharm GKB GenePA134886784
Clinical trialRBM19
Miscellaneous
canSAR (ICR)RBM19 (select the gene name)
HarmonizomeRBM19
DataMed IndexRBM19
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRBM19
EVEXRBM19
GoPubMedRBM19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:24:19 CET 2020
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