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RBM4 (RNA binding motif protein 4)

Identity

Alias_symbol (synonym)LARK
RBM4A
ZCRB3A
ZCCHC21
Other alias
HGNC (Hugo) RBM4
LocusID (NCBI) 5936
Atlas_Id 45854
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 66638617 and ends at 66646473 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RACGAP1 (12q13.12) / RBM4 (11q13.2)RBM14-RBM4 (11q13.2) / RBM4 (11q13.2)RBM14 (11q13.2) / RBM4 (11q13.2)
RBM4 (11q13.2) / CCS (11q13.2)RBM4 (11q13.2) / RBM14-RBM4 (11q13.2)TENM4 (11q14.1) / RBM4 (11q13.2)
ODZ4 RBM4 11q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RBM4   9901
Cards
Entrez_Gene (NCBI)RBM4  5936  RNA binding motif protein 4
AliasesLARK; RBM4A; ZCCHC21; ZCRB3A
GeneCards (Weizmann)RBM4
Ensembl hg19 (Hinxton)ENSG00000173933 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173933 [Gene_View]  chr11:66638617-66646473 [Contig_View]  RBM4 [Vega]
ICGC DataPortalENSG00000173933
TCGA cBioPortalRBM4
AceView (NCBI)RBM4
Genatlas (Paris)RBM4
WikiGenes5936
SOURCE (Princeton)RBM4
Genetics Home Reference (NIH)RBM4
Genomic and cartography
GoldenPath hg38 (UCSC)RBM4  -     chr11:66638617-66646473 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RBM4  -     11q13.2   [Description]    (hg19-Feb_2009)
EnsemblRBM4 - 11q13.2 [CytoView hg19]  RBM4 - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIRBM4 [Mapview hg19]  RBM4 [Mapview hg38]
OMIM602571   
Gene and transcription
Genbank (Entrez)AF087999 AK094046 AK097592 AK225071 AK303984
RefSeq transcript (Entrez)NM_001198843 NM_001198844 NM_002896
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RBM4
Cluster EST : UnigeneHs.728823 [ NCBI ]
CGAP (NCI)Hs.728823
Alternative Splicing GalleryENSG00000173933
Gene ExpressionRBM4 [ NCBI-GEO ]   RBM4 [ EBI - ARRAY_EXPRESS ]   RBM4 [ SEEK ]   RBM4 [ MEM ]
Gene Expression Viewer (FireBrowse)RBM4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5936
GTEX Portal (Tissue expression)RBM4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BWF3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BWF3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BWF3
Splice isoforms : SwissVarQ9BWF3
PhosPhoSitePlusQ9BWF3
Domaine pattern : Prosite (Expaxy)RRM (PS50102)    ZF_CCHC (PS50158)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom    Znf_CCHC   
Domain families : Pfam (Sanger)RRM_1 (PF00076)    zf-CCHC (PF00098)   
Domain families : Pfam (NCBI)pfam00076    pfam00098   
Domain families : Smart (EMBL)RRM (SM00360)  ZnF_C2HC (SM00343)  
Conserved Domain (NCBI)RBM4
DMDM Disease mutations5936
Blocks (Seattle)RBM4
PDB (SRS)2DNQ   
PDB (PDBSum)2DNQ   
PDB (IMB)2DNQ   
PDB (RSDB)2DNQ   
Structural Biology KnowledgeBase2DNQ   
SCOP (Structural Classification of Proteins)2DNQ   
CATH (Classification of proteins structures)2DNQ   
SuperfamilyQ9BWF3
Human Protein AtlasENSG00000173933
Peptide AtlasQ9BWF3
HPRD03982
IPIIPI00556034   IPI00940890   IPI00908491   IPI00965408   IPI00974578   
Protein Interaction databases
DIP (DOE-UCLA)Q9BWF3
IntAct (EBI)Q9BWF3
FunCoupENSG00000173933
BioGRIDRBM4
STRING (EMBL)RBM4
ZODIACRBM4
Ontologies - Pathways
QuickGOQ9BWF3
Ontology : AmiGOregulation of alternative mRNA splicing, via spliceosome  cap-independent translational initiation  IRES-dependent translational initiation  RNA binding  mRNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  RNA processing  mRNA processing  zinc ion binding  RNA splicing  cytoplasmic stress granule  nuclear speck  negative regulation of translation  cell differentiation  negative regulation of translation in response to stress  miRNA binding  miRNA mediated inhibition of translation  entrainment of circadian clock by photoperiod  negative regulation of translational initiation  response to arsenic-containing substance  regulation of nucleocytoplasmic transport  positive regulation of muscle cell differentiation  stress-activated MAPK cascade  pre-mRNA intronic binding  pre-mRNA intronic pyrimidine-rich binding  circadian regulation of translation  
Ontology : EGO-EBIregulation of alternative mRNA splicing, via spliceosome  cap-independent translational initiation  IRES-dependent translational initiation  RNA binding  mRNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  RNA processing  mRNA processing  zinc ion binding  RNA splicing  cytoplasmic stress granule  nuclear speck  negative regulation of translation  cell differentiation  negative regulation of translation in response to stress  miRNA binding  miRNA mediated inhibition of translation  entrainment of circadian clock by photoperiod  negative regulation of translational initiation  response to arsenic-containing substance  regulation of nucleocytoplasmic transport  positive regulation of muscle cell differentiation  stress-activated MAPK cascade  pre-mRNA intronic binding  pre-mRNA intronic pyrimidine-rich binding  circadian regulation of translation  
NDEx NetworkRBM4
Atlas of Cancer Signalling NetworkRBM4
Wikipedia pathwaysRBM4
Orthology - Evolution
OrthoDB5936
GeneTree (enSembl)ENSG00000173933
Phylogenetic Trees/Animal Genes : TreeFamRBM4
HOVERGENQ9BWF3
HOGENOMQ9BWF3
Homologs : HomoloGeneRBM4
Homology/Alignments : Family Browser (UCSC)RBM4
Gene fusions - Rearrangements
Fusion : MitelmanTENM4/RBM4 [11q14.1/11q13.2]  [t(11;11)(q13;q14)]  
Fusion: TCGAODZ4 RBM4 11q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRBM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RBM4
dbVarRBM4
ClinVarRBM4
1000_GenomesRBM4 
Exome Variant ServerRBM4
ExAC (Exome Aggregation Consortium)RBM4 (select the gene name)
Genetic variants : HAPMAP5936
Genomic Variants (DGV)RBM4 [DGVbeta]
DECIPHERRBM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRBM4 
Mutations
ICGC Data PortalRBM4 
TCGA Data PortalRBM4 
Broad Tumor PortalRBM4
OASIS PortalRBM4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRBM4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRBM4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RBM4
DgiDB (Drug Gene Interaction Database)RBM4
DoCM (Curated mutations)RBM4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RBM4 (select a term)
intoGenRBM4
Cancer3DRBM4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602571   
Orphanet
MedgenRBM4
Genetic Testing Registry RBM4
NextProtQ9BWF3 [Medical]
TSGene5936
GENETestsRBM4
Huge Navigator RBM4 [HugePedia]
snp3D : Map Gene to Disease5936
BioCentury BCIQRBM4
ClinGenRBM4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5936
Chemical/Pharm GKB GenePA34266
Clinical trialRBM4
Miscellaneous
canSAR (ICR)RBM4 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRBM4
EVEXRBM4
GoPubMedRBM4
iHOPRBM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:34:29 CEST 2017

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