RBM45 (RNA binding motif protein 45)

2014-11-01  

Identity

HGNC
RBM45
LOCATION
2q31.2
LOCUSID
129831
ALIAS
DRB1,RB-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 129831
MIM: 608888
HGNC: 24468
Ensembl: ENSG00000155636

Variants:

dbSNP: 129831
ClinVar: 129831
TCGA: ENSG00000155636
COSMIC: RBM45

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155636ENST00000286070Q8IUH3
ENSG00000155636ENST00000424099H7BZE0
ENSG00000155636ENST00000455903H7C476
ENSG00000155636ENST00000616198Q8IUH3

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
229931252012The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.33
269799932016Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.15
122205142002cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein.14
259393822015RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.10
263917652015RBM45 homo-oligomerization mediates association with ALS-linked proteins and stress granules.10
272265512016Developmentally Regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates.7
291404592017RBM45 competes with HDAC1 for binding to FUS in response to DNA damage.5

Citation

Dessen P

RBM45 (RNA binding motif protein 45)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72528/rbm45