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RBM6 (RNA binding motif protein 6)

Identity

Alias_symbol (synonym)DEF-3
3G2
NY-LU-12
g16
DEF3
Other aliasHLC-11
HGNC (Hugo) RBM6
LocusID (NCBI) 10180
Atlas_Id 42070
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49940044 and ends at 50077252 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LOC100507412 (-) / RBM6 (3p21.31)RBM6 (3p21.31) / ARIH2 (3p21.31)RBM6 (3p21.31) / BAZ2A (12q13.3)
RBM6 (3p21.31) / BCAR1 (16q23.1)RBM6 (3p21.31) / BCR (22q11.23)RBM6 (3p21.31) / CASC15 (6p22.3)
RBM6 (3p21.31) / CDK6 (7q21.2)RBM6 (3p21.31) / CSF1R (5q32)RBM6 (3p21.31) / DOCK3 (3p21.2)
RBM6 (3p21.31) / FOXJ3 (1p34.2)RBM6 (3p21.31) / MAP1B (5q13.2)RBM6 (3p21.31) / SLC38A3 (3p21.31)
RBM6 (3p21.31) / ZNF512B (20q13.33)SEMA3F (3p21.31) / RBM6 (3p21.31)STK38 (6p21.31) / RBM6 (3p21.31)
TNFAIP1 (17q11.2) / RBM6 (3p21.31)RBM6 3p21.31 / ARIH2 3p21.31SEMA3F 3p21.31 / RBM6 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;5)(p21;q32) RBM6/CSF1R


External links

Nomenclature
HGNC (Hugo)RBM6   9903
Cards
Entrez_Gene (NCBI)RBM6  10180  RNA binding motif protein 6
Aliases3G2; DEF-3; DEF3; HLC-11; 
NY-LU-12; g16
GeneCards (Weizmann)RBM6
Ensembl hg19 (Hinxton)ENSG00000004534 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004534 [Gene_View]  chr3:49940044-50077252 [Contig_View]  RBM6 [Vega]
ICGC DataPortalENSG00000004534
TCGA cBioPortalRBM6
AceView (NCBI)RBM6
Genatlas (Paris)RBM6
WikiGenes10180
SOURCE (Princeton)RBM6
Genetics Home Reference (NIH)RBM6
Genomic and cartography
GoldenPath hg38 (UCSC)RBM6  -     chr3:49940044-50077252 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RBM6  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblRBM6 - 3p21.31 [CytoView hg19]  RBM6 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIRBM6 [Mapview hg19]  RBM6 [Mapview hg38]
OMIM606886   
Gene and transcription
Genbank (Entrez)AF042857 AF069517 AF091264 AK093836 AK096765
RefSeq transcript (Entrez)NM_001167582 NM_001349190 NM_001349191 NM_001349192 NM_001349193 NM_001349194 NM_005777
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RBM6
Cluster EST : UnigeneHs.696735 [ NCBI ]
CGAP (NCI)Hs.696735
Alternative Splicing GalleryENSG00000004534
Gene ExpressionRBM6 [ NCBI-GEO ]   RBM6 [ EBI - ARRAY_EXPRESS ]   RBM6 [ SEEK ]   RBM6 [ MEM ]
Gene Expression Viewer (FireBrowse)RBM6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10180
GTEX Portal (Tissue expression)RBM6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78332   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78332  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78332
Splice isoforms : SwissVarP78332
PhosPhoSitePlusP78332
Domaine pattern : Prosite (Expaxy)G_PATCH (PS50174)    RRM (PS50102)   
Domains : Interpro (EBI)G_patch_dom    Nucleotide-bd_a/b_plait    RBM6    RBM6_RRM1    RBM6_RRM2    RRM_dom   
Domain families : Pfam (Sanger)G-patch (PF01585)   
Domain families : Pfam (NCBI)pfam01585   
Domain families : Smart (EMBL)G_patch (SM00443)  RRM (SM00360)  
Conserved Domain (NCBI)RBM6
DMDM Disease mutations10180
Blocks (Seattle)RBM6
SuperfamilyP78332
Human Protein AtlasENSG00000004534
Peptide AtlasP78332
HPRD06054
IPIIPI00297723   IPI00926778   IPI00427952   IPI00446471   IPI00925796   IPI00925552   IPI00925146   IPI00793735   IPI00927856   IPI00927608   IPI00927427   IPI00927201   IPI00927009   IPI00926809   
Protein Interaction databases
DIP (DOE-UCLA)P78332
IntAct (EBI)P78332
FunCoupENSG00000004534
BioGRIDRBM6
STRING (EMBL)RBM6
ZODIACRBM6
Ontologies - Pathways
QuickGOP78332
Ontology : AmiGODNA binding  RNA binding  protein binding  nucleus  RNA processing  
Ontology : EGO-EBIDNA binding  RNA binding  protein binding  nucleus  RNA processing  
NDEx NetworkRBM6
Atlas of Cancer Signalling NetworkRBM6
Wikipedia pathwaysRBM6
Orthology - Evolution
OrthoDB10180
GeneTree (enSembl)ENSG00000004534
Phylogenetic Trees/Animal Genes : TreeFamRBM6
HOVERGENP78332
HOGENOMP78332
Homologs : HomoloGeneRBM6
Homology/Alignments : Family Browser (UCSC)RBM6
Gene fusions - Rearrangements
Fusion : MitelmanRBM6/ARIH2 [3p21.31/3p21.31]  
Fusion : MitelmanRBM6/CSF1R [3p21.31/5q32]  [t(3;5)(p21;q33)]  
Fusion : MitelmanRBM6/SLC38A3 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanSEMA3F/RBM6 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion: TCGARBM6 3p21.31 ARIH2 3p21.31 BRCA
Fusion: TCGASEMA3F 3p21.31 RBM6 3p21.31 LUAD LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRBM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RBM6
dbVarRBM6
ClinVarRBM6
1000_GenomesRBM6 
Exome Variant ServerRBM6
ExAC (Exome Aggregation Consortium)RBM6 (select the gene name)
Genetic variants : HAPMAP10180
Genomic Variants (DGV)RBM6 [DGVbeta]
DECIPHERRBM6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRBM6 
Mutations
ICGC Data PortalRBM6 
TCGA Data PortalRBM6 
Broad Tumor PortalRBM6
OASIS PortalRBM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRBM6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRBM6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RBM6
DgiDB (Drug Gene Interaction Database)RBM6
DoCM (Curated mutations)RBM6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RBM6 (select a term)
intoGenRBM6
Cancer3DRBM6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606886   
Orphanet
MedgenRBM6
Genetic Testing Registry RBM6
NextProtP78332 [Medical]
TSGene10180
GENETestsRBM6
Target ValidationRBM6
Huge Navigator RBM6 [HugePedia]
snp3D : Map Gene to Disease10180
BioCentury BCIQRBM6
ClinGenRBM6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10180
Chemical/Pharm GKB GenePA34268
Clinical trialRBM6
Miscellaneous
canSAR (ICR)RBM6 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRBM6
EVEXRBM6
GoPubMedRBM6
iHOPRBM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:52:47 CEST 2017

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