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RBM6 (RNA binding motif protein 6)

Identity

Alias (NCBI)3G2
DEF-3
DEF3
HLC-11
NY-LU-12
g16
HGNC (Hugo) RBM6
HGNC Alias symbDEF-3
3G2
NY-LU-12
g16
DEF3
LocusID (NCBI) 10180
Atlas_Id 42070
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49940150 and ends at 50077249 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LOC100507412 (-) / RBM6 (3p21.31)RBM6 (3p21.31) / ARIH2 (3p21.31)RBM6 (3p21.31) / BAZ2A (12q13.3)
RBM6 (3p21.31) / BCAR1 (16q23.1)RBM6 (3p21.31) / BCR (22q11.23)RBM6 (3p21.31) / CASC15 (6p22.3)
RBM6 (3p21.31) / CDK6 (7q21.2)RBM6 (3p21.31) / CSF1R (5q32)RBM6 (3p21.31) / DOCK3 (3p21.2)
RBM6 (3p21.31) / FOXJ3 (1p34.2)RBM6 (3p21.31) / MAP1B (5q13.2)RBM6 (3p21.31) / SLC38A3 (3p21.31)
RBM6 (3p21.31) / ZNF512B (20q13.33)SEMA3F (3p21.31) / RBM6 (3p21.31)STK38 (6p21.31) / RBM6 (3p21.31)
TNFAIP1 (17q11.2) / RBM6 (3p21.31)RBM6 3p21.31 / ARIH2 3p21.31SEMA3F 3p21.31 / RBM6 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;5)(p21;q32) RBM6/CSF1R


External links

 

Nomenclature
HGNC (Hugo)RBM6   9903
Cards
Entrez_Gene (NCBI)RBM6    RNA binding motif protein 6
Aliases3G2; DEF-3; DEF3; HLC-11; 
NY-LU-12; g16
GeneCards (Weizmann)RBM6
Ensembl hg19 (Hinxton)ENSG00000004534 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004534 [Gene_View]  ENSG00000004534 [Sequence]  chr3:49940150-50077249 [Contig_View]  RBM6 [Vega]
ICGC DataPortalENSG00000004534
TCGA cBioPortalRBM6
AceView (NCBI)RBM6
Genatlas (Paris)RBM6
SOURCE (Princeton)RBM6
Genetics Home Reference (NIH)RBM6
Genomic and cartography
GoldenPath hg38 (UCSC)RBM6  -     chr3:49940150-50077249 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RBM6  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathRBM6 - 3p21.31 [CytoView hg19]  RBM6 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000004534
Genome Data Viewer NCBIRBM6 [Mapview hg19]  
OMIM606886   
Gene and transcription
Genbank (Entrez)AF042857 AF069517 AF091264 AK093836 AK096765
RefSeq transcript (Entrez)NM_001167582 NM_001349190 NM_001349191 NM_001349192 NM_001349193 NM_001349194 NM_005777
Consensus coding sequences : CCDS (NCBI)RBM6
Gene ExpressionRBM6 [ NCBI-GEO ]   RBM6 [ EBI - ARRAY_EXPRESS ]   RBM6 [ SEEK ]   RBM6 [ MEM ]
Gene Expression Viewer (FireBrowse)RBM6 [ Firebrowse - Broad ]
GenevisibleExpression of RBM6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10180
GTEX Portal (Tissue expression)RBM6
Human Protein AtlasENSG00000004534-RBM6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78332   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78332  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78332
PhosPhoSitePlusP78332
Domaine pattern : Prosite (Expaxy)G_PATCH (PS50174)    RRM (PS50102)   
Domains : Interpro (EBI)G_patch_dom    Nucleotide-bd_a/b_plait_sf    OCRE    RBD_domain_sf    RBM6    RBM6_OCRE    RBM6_RRM1    RBM6_RRM2    RRM_dom   
Domain families : Pfam (Sanger)G-patch (PF01585)    OCRE (PF17780)   
Domain families : Pfam (NCBI)pfam01585    pfam17780   
Domain families : Smart (EMBL)G_patch (SM00443)  RRM (SM00360)  
Conserved Domain (NCBI)RBM6
SuperfamilyP78332
AlphaFold pdb e-kbP78332   
Human Protein Atlas [tissue]ENSG00000004534-RBM6 [tissue]
HPRD06054
Protein Interaction databases
DIP (DOE-UCLA)P78332
IntAct (EBI)P78332
BioGRIDRBM6
STRING (EMBL)RBM6
ZODIACRBM6
Ontologies - Pathways
QuickGOP78332
Ontology : AmiGOmRNA splicing, via spliceosome  DNA binding  RNA binding  RNA binding  protein binding  nucleus  RNA processing  
Ontology : EGO-EBImRNA splicing, via spliceosome  DNA binding  RNA binding  RNA binding  protein binding  nucleus  RNA processing  
NDEx NetworkRBM6
Atlas of Cancer Signalling NetworkRBM6
Wikipedia pathwaysRBM6
Orthology - Evolution
OrthoDB10180
GeneTree (enSembl)ENSG00000004534
Phylogenetic Trees/Animal Genes : TreeFamRBM6
Homologs : HomoloGeneRBM6
Homology/Alignments : Family Browser (UCSC)RBM6
Gene fusions - Rearrangements
Fusion : MitelmanRBM6/ARIH2 [3p21.31/3p21.31]  
Fusion : MitelmanRBM6/CSF1R [3p21.31/5q32]  
Fusion : MitelmanRBM6/SLC38A3 [3p21.31/3p21.31]  
Fusion : MitelmanSEMA3F/RBM6 [3p21.31/3p21.31]  
Fusion : QuiverRBM6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRBM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RBM6
dbVarRBM6
ClinVarRBM6
MonarchRBM6
1000_GenomesRBM6 
Exome Variant ServerRBM6
GNOMAD BrowserENSG00000004534
Varsome BrowserRBM6
ACMGRBM6 variants
VarityP78332
Genomic Variants (DGV)RBM6 [DGVbeta]
DECIPHERRBM6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRBM6 
Mutations
ICGC Data PortalRBM6 
TCGA Data PortalRBM6 
Broad Tumor PortalRBM6
OASIS PortalRBM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRBM6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRBM6
Mutations and Diseases : HGMDRBM6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRBM6
DgiDB (Drug Gene Interaction Database)RBM6
DoCM (Curated mutations)RBM6
CIViC (Clinical Interpretations of Variants in Cancer)RBM6
Cancer3DRBM6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606886   
Orphanet
DisGeNETRBM6
MedgenRBM6
Genetic Testing Registry RBM6
NextProtP78332 [Medical]
GENETestsRBM6
Target ValidationRBM6
Huge Navigator RBM6 [HugePedia]
ClinGenRBM6
Clinical trials, drugs, therapy
MyCancerGenomeRBM6
Protein Interactions : CTDRBM6
Pharm GKB GenePA34268
PharosP78332
Clinical trialRBM6
Miscellaneous
canSAR (ICR)RBM6
HarmonizomeRBM6
DataMed IndexRBM6
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRBM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:28:28 CEST 2021

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