RBP4 (retinol binding protein 4)

2009-06-01  

Identity

HGNC
LOCATION
10q23.33
LOCUSID
ALIAS
MCOPCB10,RDCCAS
FUSION GENES

Other Information

Locus ID:

NCBI: 5950
MIM: 180250
HGNC: 9922
Ensembl: ENSG00000138207

Variants:

dbSNP: 5950
ClinVar: 5950
TCGA: ENSG00000138207
COSMIC: RBP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138207ENST00000371464P02753
ENSG00000138207ENST00000371467P02753
ENSG00000138207ENST00000371469Q5VY30
ENSG00000138207ENST00000629763Q5VY30

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
4500

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Diseases associated with visual transductionREACTOMER-HSA-2474795
Retinoid cycle disease eventsREACTOMER-HSA-2453864
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Retinoid metabolism disease eventsREACTOMER-HSA-6809583
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170656842006Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes.102
176188582007Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass.101
183160312008RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome.84
170033462006Retinol-binding protein 4 in human obesity.83
246069042014RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance.78
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
218357642011RBP4: a controversial adipokine.67
175952592007Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone.66
171643132007Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects.56
172594772007High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans.54

Citation

Dessen P

RBP4 (retinol binding protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50989/rbp4