RC3H1 (ring finger and CCCH-type domains 1)

2016-10-01  

Identity

HGNC
LOCATION
1q25.1
LOCUSID
ALIAS
FHL6,IMDSHY,RNF198,ROQUIN
FUSION GENES

Other Information

Locus ID:

NCBI: 149041
MIM: 609424
HGNC: 29434
Ensembl: ENSG00000135870

Variants:

dbSNP: 149041
ClinVar: 149041
TCGA: ENSG00000135870
COSMIC: RC3H1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135870ENST00000258349Q5TC82
ENSG00000135870ENST00000367694Q5TC82
ENSG00000135870ENST00000367696Q5TC82

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
260004822015Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.87
258869942015MicroRNA signatures differentiate Crohn's disease from ulcerative colitis.43
261701702015RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.35
250260782014The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.29
255044712014Roquin binding to target mRNAs involves a winged helix-turn-helix motif.16
262496982015Structure of human Roquin-2 and its complex with constitutive-decay element RNA.10
264896702015New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.10
293521142018Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.9
226853172012Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.6
259558202015Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses.5

Citation

Dessen P

RC3H1 (ring finger and CCCH-type domains 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56174/rc3h1