Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RC3H2 (ring finger and CCCH-type domains 2)

Identity

Alias_namesMNAB
membrane associated DNA binding protein
ring finger and CCCH-type zinc finger domains 2
Alias_symbol (synonym)FLJ20301
FLJ20713
RNF164
Other alias
HGNC (Hugo) RC3H2
LocusID (NCBI) 54542
Atlas_Id 53036
Location 9q33.2  [Link to chromosome band 9q33]
Location_base_pair Starts at 122849453 and ends at 122905283 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RC3H2 (9q33.2) / GNA14 (9q21.2)RC3H2 (9q33.2) / NDRG3 (20q11.23)RC3H2 (9q33.2) / RGS3 (9q32)
RC3H2 9q33.2 / GNA14 9q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)RC3H2   21461
Cards
Entrez_Gene (NCBI)RC3H2  54542  ring finger and CCCH-type domains 2
AliasesMNAB; RNF164
GeneCards (Weizmann)RC3H2
Ensembl hg19 (Hinxton)ENSG00000056586 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000056586 [Gene_View]  chr9:122849453-122905283 [Contig_View]  RC3H2 [Vega]
ICGC DataPortalENSG00000056586
TCGA cBioPortalRC3H2
AceView (NCBI)RC3H2
Genatlas (Paris)RC3H2
WikiGenes54542
SOURCE (Princeton)RC3H2
Genetics Home Reference (NIH)RC3H2
Genomic and cartography
GoldenPath hg38 (UCSC)RC3H2  -     chr9:122849453-122905283 -  9q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RC3H2  -     9q33.2   [Description]    (hg19-Feb_2009)
EnsemblRC3H2 - 9q33.2 [CytoView hg19]  RC3H2 - 9q33.2 [CytoView hg38]
Mapping of homologs : NCBIRC3H2 [Mapview hg19]  RC3H2 [Mapview hg38]
OMIM615231   
Gene and transcription
Genbank (Entrez)AF255303 AF255304 AK000308 AK000720 AK027042
RefSeq transcript (Entrez)NM_001100588 NM_018835
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RC3H2
Cluster EST : UnigeneHs.709775 [ NCBI ]
CGAP (NCI)Hs.709775
Alternative Splicing GalleryENSG00000056586
Gene ExpressionRC3H2 [ NCBI-GEO ]   RC3H2 [ EBI - ARRAY_EXPRESS ]   RC3H2 [ SEEK ]   RC3H2 [ MEM ]
Gene Expression Viewer (FireBrowse)RC3H2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54542
GTEX Portal (Tissue expression)RC3H2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBD1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBD1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBD1
Splice isoforms : SwissVarQ9HBD1
PhosPhoSitePlusQ9HBD1
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)RC3H2    Znf-RING_LisH    Znf_CCCH    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)zf-CCCH (PF00642)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00642    pfam13445   
Domain families : Smart (EMBL)RING (SM00184)  ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)RC3H2
DMDM Disease mutations54542
Blocks (Seattle)RC3H2
PDB (SRS)4Z30    4Z31    4ZLC    4ZLD   
PDB (PDBSum)4Z30    4Z31    4ZLC    4ZLD   
PDB (IMB)4Z30    4Z31    4ZLC    4ZLD   
PDB (RSDB)4Z30    4Z31    4ZLC    4ZLD   
Structural Biology KnowledgeBase4Z30    4Z31    4ZLC    4ZLD   
SCOP (Structural Classification of Proteins)4Z30    4Z31    4ZLC    4ZLD   
CATH (Classification of proteins structures)4Z30    4Z31    4ZLC    4ZLD   
SuperfamilyQ9HBD1
Human Protein AtlasENSG00000056586
Peptide AtlasQ9HBD1
HPRD14726
IPIIPI00177819   IPI00552838   IPI00873992   IPI00643666   IPI00643035   IPI00386606   IPI00385357   IPI00646536   IPI00607854   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBD1
IntAct (EBI)Q9HBD1
FunCoupENSG00000056586
BioGRIDRC3H2
STRING (EMBL)RC3H2
ZODIACRC3H2
Ontologies - Pathways
QuickGOQ9HBD1
Ontology : AmiGOprotein polyubiquitination  P-body  B cell homeostasis  DNA binding  RNA binding  mRNA binding  ubiquitin-protein transferase activity  zinc ion binding  post-embryonic development  cell surface  posttranscriptional regulation of gene expression  membrane  multicellular organism growth  T cell proliferation  T cell homeostasis  lung alveolus development  lymph node development  spleen development  limb development  T follicular helper cell differentiation  positive regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBIprotein polyubiquitination  P-body  B cell homeostasis  DNA binding  RNA binding  mRNA binding  ubiquitin-protein transferase activity  zinc ion binding  post-embryonic development  cell surface  posttranscriptional regulation of gene expression  membrane  multicellular organism growth  T cell proliferation  T cell homeostasis  lung alveolus development  lymph node development  spleen development  limb development  T follicular helper cell differentiation  positive regulation of NIK/NF-kappaB signaling  
NDEx NetworkRC3H2
Atlas of Cancer Signalling NetworkRC3H2
Wikipedia pathwaysRC3H2
Orthology - Evolution
OrthoDB54542
GeneTree (enSembl)ENSG00000056586
Phylogenetic Trees/Animal Genes : TreeFamRC3H2
HOVERGENQ9HBD1
HOGENOMQ9HBD1
Homologs : HomoloGeneRC3H2
Homology/Alignments : Family Browser (UCSC)RC3H2
Gene fusions - Rearrangements
Fusion : MitelmanRC3H2/GNA14 [9q33.2/9q21.2]  
Fusion : MitelmanRC3H2/RGS3 [9q33.2/9q32]  [t(9;9)(q32;q33)]  
Fusion: TCGARC3H2 9q33.2 GNA14 9q21.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRC3H2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RC3H2
dbVarRC3H2
ClinVarRC3H2
1000_GenomesRC3H2 
Exome Variant ServerRC3H2
ExAC (Exome Aggregation Consortium)RC3H2 (select the gene name)
Genetic variants : HAPMAP54542
Genomic Variants (DGV)RC3H2 [DGVbeta]
DECIPHERRC3H2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRC3H2 
Mutations
ICGC Data PortalRC3H2 
TCGA Data PortalRC3H2 
Broad Tumor PortalRC3H2
OASIS PortalRC3H2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRC3H2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRC3H2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RC3H2
DgiDB (Drug Gene Interaction Database)RC3H2
DoCM (Curated mutations)RC3H2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RC3H2 (select a term)
intoGenRC3H2
Cancer3DRC3H2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615231   
Orphanet
MedgenRC3H2
Genetic Testing Registry RC3H2
NextProtQ9HBD1 [Medical]
TSGene54542
GENETestsRC3H2
Target ValidationRC3H2
Huge Navigator RC3H2 [HugePedia]
snp3D : Map Gene to Disease54542
BioCentury BCIQRC3H2
ClinGenRC3H2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54542
Chemical/Pharm GKB GenePA162400905
Clinical trialRC3H2
Miscellaneous
canSAR (ICR)RC3H2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRC3H2
EVEXRC3H2
GoPubMedRC3H2
iHOPRC3H2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:12:45 CEST 2017

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