RCAN3 (RCAN family member 3)

2010-03-01  

Identity

HGNC
RCAN3
LOCATION
1p36.11
LOCUSID
11123
ALIAS
DSCR1L2,MCIP3,RCN3,hRCN3

Other Information

Locus ID:

NCBI: 11123
MIM: 605860
HGNC: 3042
Ensembl: ENSG00000117602

Variants:

dbSNP: 11123
ClinVar: 11123
TCGA: ENSG00000117602
COSMIC: RCAN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117602ENST00000374393Q9UKA8
ENSG00000117602ENST00000374395Q9UKA8
ENSG00000117602ENST00000374395A0A024RAH2
ENSG00000117602ENST00000412742Q9UKA8
ENSG00000117602ENST00000425530Q9UKA8
ENSG00000117602ENST00000436717Q9UKA8
ENSG00000117602ENST00000482807H0YF64
ENSG00000117602ENST00000538532Q9UKA8
ENSG00000117602ENST00000538532A0A024RAH2
ENSG00000117602ENST00000610732Q9UKA8
ENSG00000117602ENST00000610732A0A024RAH2
ENSG00000117602ENST00000616511Q9UKA8
ENSG00000117602ENST00000618490Q9UKA8
ENSG00000117602ENST00000630217Q9UKA8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25
198192662009Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway.22
172702912007RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression.13
219610372011Complexity of bidirectional transcription and alternative splicing at human RCAN3 locus.4
180223292008Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms.3
210427872010Human RCAN3 gene expression and cell growth in endothelial cells.3
165164082006Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3).2
259166532015A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer.1

Citation

Dessen P

RCAN3 (RCAN family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51364/rcan3