RCC1 (regulator of chromosome condensation 1)

2003-11-01  

Identity

HGNC
LOCATION
1p35.3
LOCUSID
ALIAS
CHC1,RCC1-I,SNHG3-RCC1
FUSION GENES

Other Information

Locus ID:

NCBI: 1104
MIM: 179710
HGNC: 1913
Ensembl: ENSG00000180198

Variants:

dbSNP: 1104
ClinVar: 1104
TCGA: ENSG00000180198
COSMIC: RCC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180198ENST00000373831P18754
ENSG00000180198ENST00000373831A0A0S2Z404
ENSG00000180198ENST00000373832P18754
ENSG00000180198ENST00000373832Q5T081
ENSG00000180198ENST00000373833P18754
ENSG00000180198ENST00000373833Q5T081
ENSG00000180198ENST00000398958P18754
ENSG00000180198ENST00000398958Q5T081
ENSG00000180198ENST00000411533C9JW69
ENSG00000180198ENST00000419074C9JMJ4
ENSG00000180198ENST00000427469C9JRH2
ENSG00000180198ENST00000430407C9JQZ4
ENSG00000180198ENST00000434290C9J3R0
ENSG00000180198ENST00000486790M0R1Q8
ENSG00000180198ENST00000649185P18754
ENSG00000180198ENST00000649185A0A0S2Z404

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Rev-mediated nuclear export of HIV RNAREACTOMER-HSA-165054
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Rev with host cellular proteinsREACTOMER-HSA-177243
Nuclear import of Rev proteinREACTOMER-HSA-180746

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174357512007N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.59
150140432004Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells.51
206684492010NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.48
121948282002Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.38
184424862008The RCC1 superfamily: from genes, to function, to disease.38
187625802008Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.34
119322512002Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor.24
190608932009Apoptotic histone modification inhibits nuclear transport by regulating RCC1.22
203478442010RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex.21
178553852007RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation.13

Citation

Dessen P

RCC1 (regulator of chromosome condensation 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40069/rcc1