RCC2 (regulator of chromosome condensation 2)

2013-11-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
TD-60
FUSION GENES

Other Information

Locus ID:

NCBI: 55920
MIM: 609587
HGNC: 30297
Ensembl: ENSG00000179051

Variants:

dbSNP: 55920
ClinVar: 55920
TCGA: ENSG00000179051
COSMIC: RCC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179051ENST00000375433Q9P258
ENSG00000179051ENST00000375433A0A024RAC5
ENSG00000179051ENST00000375436Q9P258
ENSG00000179051ENST00000375436A0A024RAC5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197382012009Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.105
188499932008Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.47
129196802003The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.40
234428842013MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2.25
208737692010Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage.18
261585372015TD-60 links RalA GTPase function to the CPC in mitosis.15
286069212017Overexpression of RCC2 Enhances Cell Motility and Promotes Tumor Metastasis in Lung Adenocarcinoma by Inducing Epithelial-Mesenchymal Transition.14
259109522015Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.12
233884552013TD-60 is required for interphase cell cycle progression.11
293210042018RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation.11

Citation

Dessen P

RCC2 (regulator of chromosome condensation 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53610/rcc2