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RCC2 (regulator of chromosome condensation 2)

Identity

Alias_symbol (synonym)TD-60
Other alias
HGNC (Hugo) RCC2
LocusID (NCBI) 55920
Atlas_Id 53610
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 17406755 and ends at 17439754 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD68 (17p13.1) / RCC2 (1p36.13)MINOS1 (1p36.13) / RCC2 (1p36.13)RCC2 (1p36.13) / PADI4 (1p36.13)
RCC2 1p36.13 / PADI4 1p36.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  MINOS1/RCC2 (1p36)
RCC2/PADI4 (1p36)


External links

Nomenclature
HGNC (Hugo)RCC2   30297
Cards
Entrez_Gene (NCBI)RCC2  55920  regulator of chromosome condensation 2
AliasesTD-60
GeneCards (Weizmann)RCC2
Ensembl hg19 (Hinxton)ENSG00000179051 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179051 [Gene_View]  ENSG00000179051 [Sequence]  chr1:17406755-17439754 [Contig_View]  RCC2 [Vega]
ICGC DataPortalENSG00000179051
TCGA cBioPortalRCC2
AceView (NCBI)RCC2
Genatlas (Paris)RCC2
WikiGenes55920
SOURCE (Princeton)RCC2
Genetics Home Reference (NIH)RCC2
Genomic and cartography
GoldenPath hg38 (UCSC)RCC2  -     chr1:17406755-17439754 -  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RCC2  -     1p36.13   [Description]    (hg19-Feb_2009)
GoldenPathRCC2 - 1p36.13 [CytoView hg19]  RCC2 - 1p36.13 [CytoView hg38]
ImmunoBaseENSG00000179051
Mapping of homologs : NCBIRCC2 [Mapview hg19]  RCC2 [Mapview hg38]
OMIM609587   
Gene and transcription
Genbank (Entrez)AB040903 AJ421269 AK026005 AK126021 AL359612
RefSeq transcript (Entrez)NM_001136204 NM_018715
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RCC2
Cluster EST : UnigeneHs.380857 [ NCBI ]
CGAP (NCI)Hs.380857
Alternative Splicing GalleryENSG00000179051
Gene ExpressionRCC2 [ NCBI-GEO ]   RCC2 [ EBI - ARRAY_EXPRESS ]   RCC2 [ SEEK ]   RCC2 [ MEM ]
Gene Expression Viewer (FireBrowse)RCC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55920
GTEX Portal (Tissue expression)RCC2
Human Protein AtlasENSG00000179051-RCC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P258   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P258  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P258
Splice isoforms : SwissVarQ9P258
PhosPhoSitePlusQ9P258
Domaine pattern : Prosite (Expaxy)RCC1_2 (PS00626)    RCC1_3 (PS50012)   
Domains : Interpro (EBI)RCC1/BLIP-II    Reg_chr_condens   
Domain families : Pfam (Sanger)RCC1 (PF00415)   
Domain families : Pfam (NCBI)pfam00415   
Conserved Domain (NCBI)RCC2
DMDM Disease mutations55920
Blocks (Seattle)RCC2
PDB (RSDB)5GWN   
PDB Europe5GWN   
PDB (PDBSum)5GWN   
PDB (IMB)5GWN   
Structural Biology KnowledgeBase5GWN   
SCOP (Structural Classification of Proteins)5GWN   
CATH (Classification of proteins structures)5GWN   
SuperfamilyQ9P258
Human Protein Atlas [tissue]ENSG00000179051-RCC2 [tissue]
Peptide AtlasQ9P258
HPRD18171
IPIIPI00465044   
Protein Interaction databases
DIP (DOE-UCLA)Q9P258
IntAct (EBI)Q9P258
FunCoupENSG00000179051
BioGRIDRCC2
STRING (EMBL)RCC2
ZODIACRCC2
Ontologies - Pathways
QuickGOQ9P258
Ontology : AmiGORNA binding  guanyl-nucleotide exchange factor activity  protein binding  nucleolus  cytosol  microtubule  plasma membrane  cell cycle  integrin-mediated signaling pathway  microtubule binding  regulation of fibroblast migration  positive regulation of G2/M transition of mitotic cell cycle  membrane  protein kinase binding  protein domain specific binding  regulation of cell migration  midbody  small GTPase binding  early endosome membrane  negative regulation of GTPase activity  negative regulation of GTPase activity  chromosome, centromeric core domain  establishment of protein localization  focal adhesion assembly  Rac GTPase binding  cell division  negative regulation of focal adhesion assembly  positive regulation of attachment of spindle microtubules to kinetochore  chromosome passenger complex localization to kinetochore  activation of GTPase activity  negative regulation of substrate adhesion-dependent cell spreading  regulation of ruffle assembly  mitotic spindle midzone  
Ontology : EGO-EBIRNA binding  guanyl-nucleotide exchange factor activity  protein binding  nucleolus  cytosol  microtubule  plasma membrane  cell cycle  integrin-mediated signaling pathway  microtubule binding  regulation of fibroblast migration  positive regulation of G2/M transition of mitotic cell cycle  membrane  protein kinase binding  protein domain specific binding  regulation of cell migration  midbody  small GTPase binding  early endosome membrane  negative regulation of GTPase activity  negative regulation of GTPase activity  chromosome, centromeric core domain  establishment of protein localization  focal adhesion assembly  Rac GTPase binding  cell division  negative regulation of focal adhesion assembly  positive regulation of attachment of spindle microtubules to kinetochore  chromosome passenger complex localization to kinetochore  activation of GTPase activity  negative regulation of substrate adhesion-dependent cell spreading  regulation of ruffle assembly  mitotic spindle midzone  
NDEx NetworkRCC2
Atlas of Cancer Signalling NetworkRCC2
Wikipedia pathwaysRCC2
Orthology - Evolution
OrthoDB55920
GeneTree (enSembl)ENSG00000179051
Phylogenetic Trees/Animal Genes : TreeFamRCC2
HOGENOMQ9P258
Homologs : HomoloGeneRCC2
Homology/Alignments : Family Browser (UCSC)RCC2
Gene fusions - Rearrangements
Fusion : MitelmanMINOS1/RCC2 [1p36.13/1p36.13]  [t(1;1)(p36;p36)]  
Fusion : MitelmanRCC2/PADI4 [1p36.13/1p36.13]  [t(1;1)(p36;p36)]  
Fusion PortalRCC2 1p36.13 PADI4 1p36.13 BRCA
Fusion : QuiverRCC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRCC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RCC2
dbVarRCC2
ClinVarRCC2
1000_GenomesRCC2 
Exome Variant ServerRCC2
ExAC (Exome Aggregation Consortium)ENSG00000179051
GNOMAD BrowserENSG00000179051
Varsome BrowserRCC2
Genetic variants : HAPMAP55920
Genomic Variants (DGV)RCC2 [DGVbeta]
DECIPHERRCC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRCC2 
Mutations
ICGC Data PortalRCC2 
TCGA Data PortalRCC2 
Broad Tumor PortalRCC2
OASIS PortalRCC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRCC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRCC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RCC2
DgiDB (Drug Gene Interaction Database)RCC2
DoCM (Curated mutations)RCC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RCC2 (select a term)
intoGenRCC2
Cancer3DRCC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609587   
Orphanet
DisGeNETRCC2
MedgenRCC2
Genetic Testing Registry RCC2
NextProtQ9P258 [Medical]
TSGene55920
GENETestsRCC2
Target ValidationRCC2
Huge Navigator RCC2 [HugePedia]
snp3D : Map Gene to Disease55920
BioCentury BCIQRCC2
ClinGenRCC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55920
Chemical/Pharm GKB GenePA142671091
Clinical trialRCC2
Miscellaneous
canSAR (ICR)RCC2 (select the gene name)
DataMed IndexRCC2
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRCC2
EVEXRCC2
GoPubMedRCC2
iHOPRCC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 7 18:15:13 CEST 2019

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