RDH10 (retinol dehydrogenase 10)

2007-11-01  

Identity

HGNC
LOCATION
8q21.11
LOCUSID
ALIAS
SDR16C4
FUSION GENES

Other Information

Locus ID:

NCBI: 157506
MIM: 607599
HGNC: 19975
Ensembl: ENSG00000121039

Variants:

dbSNP: 157506
ClinVar: 157506
TCGA: ENSG00000121039
COSMIC: RDH10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121039ENST00000240285Q8IZV5
ENSG00000121039ENST00000240285A0A024R7X6
ENSG00000121039ENST00000519380E5RK48
ENSG00000121039ENST00000521928E5RHJ9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

References

Pubmed IDYearTitleCitations
194737192010Identification of genes associated with non-small-cell lung cancer promotion and progression.40
247333972014The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.36
185027502008Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase.30
213457902011Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft culture.17
191027272009Characterization of key residues and membrane association domains in retinol dehydrogenase 10.10
256276862015Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.10
172187792007Forced expression of RDH10 gene retards growth of HepG2 cells.8
282324912017The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis.8
277936052017Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.6
281693992017Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.6

Citation

Dessen P

RDH10 (retinol dehydrogenase 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49788/rdh10